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The Role of Vitamins in the Pathogenesis of Non-alcoholic Fatty Liver Disease.
Integr Med Insights 2016; 11:19-25IM

Abstract

The incidence of non-alcoholic fatty liver disease (NAFLD) is rising rapidly in parallel with obesity rates. The underlying pathogenesis of NAFLD remains an enigma but is largely influenced by individual lifestyle choices involving diet and exercise. Therefore, studies have highlighted the importance of calorie reduction and macronutrient composition (eg, carbohydrate and fat) in modifying disease outcomes. Micronutrients are also believed to play a role in disease progression. There are now an increasing number of studies linking vitamins with NAFLD, particularly vitamin E, and the supplementation of several different vitamins has been demonstrated as a promising therapeutic option in the treatment of NAFLD. This review provides a broad overview of the potential role of vitamins in NAFLD development and disease management.

Authors+Show Affiliations

Institute for Liver and Digestive Health, University College London, London, UK.Institute for Liver and Digestive Health, University College London, London, UK.Institute for Liver and Digestive Health, University College London, London, UK.; Department of Gastroenterology and Hepatology, Guy's and St Thomas' Hospital NHS Foundation Trust, London, UK.Institute for Liver and Digestive Health, University College London, London, UK.; Department of Gastroenterology and Hepatology, Guy's and St Thomas' Hospital NHS Foundation Trust, London, UK.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

27147819

Citation

Li, Jiawei, et al. "The Role of Vitamins in the Pathogenesis of Non-alcoholic Fatty Liver Disease." Integrative Medicine Insights, vol. 11, 2016, pp. 19-25.
Li J, Cordero P, Nguyen V, et al. The Role of Vitamins in the Pathogenesis of Non-alcoholic Fatty Liver Disease. Integr Med Insights. 2016;11:19-25.
Li, J., Cordero, P., Nguyen, V., & Oben, J. A. (2016). The Role of Vitamins in the Pathogenesis of Non-alcoholic Fatty Liver Disease. Integrative Medicine Insights, 11, pp. 19-25. doi:10.4137/IMI.S31451.
Li J, et al. The Role of Vitamins in the Pathogenesis of Non-alcoholic Fatty Liver Disease. Integr Med Insights. 2016;11:19-25. PubMed PMID: 27147819.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Role of Vitamins in the Pathogenesis of Non-alcoholic Fatty Liver Disease. AU - Li,Jiawei, AU - Cordero,Paul, AU - Nguyen,Vi, AU - Oben,Jude A, Y1 - 2016/04/27/ PY - 2015/09/04/received PY - 2015/11/19/revised PY - 2015/11/24/accepted PY - 2016/5/6/entrez PY - 2016/5/6/pubmed PY - 2016/5/6/medline KW - fatty liver KW - metabolic syndrome KW - micronutrient KW - oxidative stress KW - vitamin SP - 19 EP - 25 JF - Integrative medicine insights JO - Integr Med Insights VL - 11 N2 - The incidence of non-alcoholic fatty liver disease (NAFLD) is rising rapidly in parallel with obesity rates. The underlying pathogenesis of NAFLD remains an enigma but is largely influenced by individual lifestyle choices involving diet and exercise. Therefore, studies have highlighted the importance of calorie reduction and macronutrient composition (eg, carbohydrate and fat) in modifying disease outcomes. Micronutrients are also believed to play a role in disease progression. There are now an increasing number of studies linking vitamins with NAFLD, particularly vitamin E, and the supplementation of several different vitamins has been demonstrated as a promising therapeutic option in the treatment of NAFLD. This review provides a broad overview of the potential role of vitamins in NAFLD development and disease management. SN - 1177-3936 UR - https://www.unboundmedicine.com/medline/citation/27147819/full_citation L2 - http://journals.sagepub.com/doi/full/10.4137/IMI.S31451?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -