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Improving Interference Control in ADHD Patients with Transcranial Direct Current Stimulation (tDCS).
Front Cell Neurosci. 2016; 10:72.FC

Abstract

The use of transcranial direct current stimulation (tDCS) in patients with attention deficit hyperactivity disorder (ADHD) has been suggested as a promising alternative to psychopharmacological treatment approaches due to its local and network effects on brain activation. In the current study, we investigated the impact of tDCS over the right inferior frontal gyrus (rIFG) on interference control in 21 male adolescents with ADHD and 21 age matched healthy controls aged 13-17 years, who underwent three separate sessions of tDCS (anodal, cathodal, and sham) while completing a Flanker task. Even though anodal stimulation appeared to diminish commission errors in the ADHD group, the overall analysis revealed no significant effect of tDCS. Since participants showed a considerable learning effect from the first to the second session, performance in the first session was separately analyzed. ADHD patients receiving sham stimulation in the first session showed impaired interference control compared to healthy control participants whereas ADHD patients who were exposed to anodal stimulation, showed comparable performance levels (commission errors, reaction time variability) to the control group. These results suggest that anodal tDCS of the right inferior frontal gyrus could improve interference control in patients with ADHD.

Authors+Show Affiliations

Department of Child and Adolescent Psychiatry and Psychotherapy, University of Magdeburg Magdeburg, Germany.Department of Neurology, University of Magdeburg Magdeburg, Germany.Scientific Computing and Imaging Institute, Center for Integrated Biomedical Computing, University of Utah Salt Lake City, UT, USA.Department of Child and Adolescent Psychiatry and Psychotherapy, University of Magdeburg Magdeburg, Germany.Department of Child and Adolescent Psychiatry and Psychotherapy, University of Magdeburg Magdeburg, Germany.Department of Child and Adolescent Psychiatry and Psychotherapy, University of Magdeburg Magdeburg, Germany.Department of Child and Adolescent Psychiatry and Psychotherapy, University of MagdeburgMagdeburg, Germany; Center for Behavioral Brain Sciences, University of MagdeburgMagdeburg, Germany.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27147964

Citation

Breitling, Carolin, et al. "Improving Interference Control in ADHD Patients With Transcranial Direct Current Stimulation (tDCS)." Frontiers in Cellular Neuroscience, vol. 10, 2016, p. 72.
Breitling C, Zaehle T, Dannhauer M, et al. Improving Interference Control in ADHD Patients with Transcranial Direct Current Stimulation (tDCS). Front Cell Neurosci. 2016;10:72.
Breitling, C., Zaehle, T., Dannhauer, M., Bonath, B., Tegelbeckers, J., Flechtner, H. H., & Krauel, K. (2016). Improving Interference Control in ADHD Patients with Transcranial Direct Current Stimulation (tDCS). Frontiers in Cellular Neuroscience, 10, 72. https://doi.org/10.3389/fncel.2016.00072
Breitling C, et al. Improving Interference Control in ADHD Patients With Transcranial Direct Current Stimulation (tDCS). Front Cell Neurosci. 2016;10:72. PubMed PMID: 27147964.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Improving Interference Control in ADHD Patients with Transcranial Direct Current Stimulation (tDCS). AU - Breitling,Carolin, AU - Zaehle,Tino, AU - Dannhauer,Moritz, AU - Bonath,Björn, AU - Tegelbeckers,Jana, AU - Flechtner,Hans-Henning, AU - Krauel,Kerstin, Y1 - 2016/03/22/ PY - 2015/07/01/received PY - 2016/03/07/accepted PY - 2016/5/6/entrez PY - 2016/5/6/pubmed PY - 2016/5/6/medline KW - ADHD KW - attention deficit hyperactivity disorder KW - flanker task KW - inhibitory control KW - interference control KW - right inferior frontal gyrus KW - tDCS KW - transcranial direct current stimulation SP - 72 EP - 72 JF - Frontiers in cellular neuroscience JO - Front Cell Neurosci VL - 10 N2 - The use of transcranial direct current stimulation (tDCS) in patients with attention deficit hyperactivity disorder (ADHD) has been suggested as a promising alternative to psychopharmacological treatment approaches due to its local and network effects on brain activation. In the current study, we investigated the impact of tDCS over the right inferior frontal gyrus (rIFG) on interference control in 21 male adolescents with ADHD and 21 age matched healthy controls aged 13-17 years, who underwent three separate sessions of tDCS (anodal, cathodal, and sham) while completing a Flanker task. Even though anodal stimulation appeared to diminish commission errors in the ADHD group, the overall analysis revealed no significant effect of tDCS. Since participants showed a considerable learning effect from the first to the second session, performance in the first session was separately analyzed. ADHD patients receiving sham stimulation in the first session showed impaired interference control compared to healthy control participants whereas ADHD patients who were exposed to anodal stimulation, showed comparable performance levels (commission errors, reaction time variability) to the control group. These results suggest that anodal tDCS of the right inferior frontal gyrus could improve interference control in patients with ADHD. SN - 1662-5102 UR - https://www.unboundmedicine.com/medline/citation/27147964/Improving_Interference_Control_in_ADHD_Patients_with_Transcranial_Direct_Current_Stimulation__tDCS__ L2 - https://doi.org/10.3389/fncel.2016.00072 DB - PRIME DP - Unbound Medicine ER -
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