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Bioavailability of long chain omega-3 polyunsaturated fatty acids from phospholipid-rich herring roe oil in men and women with mildly elevated triacylglycerols.

Abstract

This randomized, single-blind, crossover trial assessed the bioavailability of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and docosapentaenoic acid (DPA) from two different sources, each examined over a 12h period following consumption of a single serving and after 2-weeks of daily supplementation. Thirty-two adults with fasting triacylglycerol (TAG) concentrations between 100 and 399mg/dL were randomly assigned, with stratification by sex and age, to receive 12 capsules/day containing either phospholipid (PL)-rich herring roe oil (Romega® 30, 628mg/day EPA; 1810mg/day DHA; 137mg/day DPA) or TAG-rich fish oil (575mg/day EPA; 1843mg/day DHA; 259mg/day DPA) each for a 2-week period separated by a 4 week washout. The net incremental area under the curve from 0 to 12h for EPA, DHA, and EPA+DHA in plasma phosphatidylcholine (PC) were significantly higher (p<0.01 for all) after Romega 30 supplementation compared to fish oil. Similar results were observed when the data for the Romega 30 condition were normalized to fish oil EPA and DHA intakes (p<0.001 for all). After the 2-week supplementation period, fasting plasma PC EPA+ DHA was elevated by ~2.8 to 3.0-fold relative to baseline in both conditions (p<0.0001 for each), but there was no significant difference in the change from baseline (p=0.422) between Romega 30 (baseline=62.2±3.8µg/mL vs. end of study=172.9±11.7µg/mL) and fish oil (baseline=62.0±3.4µg/mL vs. end of study=185.4±11.2µg/mL) conditions. Similar results were observed for each individual LC n-3 PUFA in plasma PC after 2 weeks of supplementation. These data demonstrate that PL-rich herring roe is a well-tolerated and bioavailable source of LC n-3 PUFA.

Authors+Show Affiliations

Biofortis Clinical Research, Addison, IL, United States. Electronic address: chad.cook@mxns.com.Arctic Nutrition AS, Ørsta N-6155, Norway.Arctic Nutrition AS, Ørsta N-6155, Norway.Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada V5Z4H4; Child and Family Research Institute, Vancouver, BC, Canada V5Z4H4.Biofortis Clinical Research, Addison, IL, United States.Biofortis Clinical Research, Addison, IL, United States.Arctic Nutrition AS, Ørsta N-6155, Norway.Biofortis Clinical Research, Addison, IL, United States.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27151222

Citation

Cook, Chad M., et al. "Bioavailability of Long Chain Omega-3 Polyunsaturated Fatty Acids From Phospholipid-rich Herring Roe Oil in Men and Women With Mildly Elevated Triacylglycerols." Prostaglandins, Leukotrienes, and Essential Fatty Acids, vol. 111, 2016, pp. 17-24.
Cook CM, Hallaråker H, Sæbø PC, et al. Bioavailability of long chain omega-3 polyunsaturated fatty acids from phospholipid-rich herring roe oil in men and women with mildly elevated triacylglycerols. Prostaglandins Leukot Essent Fatty Acids. 2016;111:17-24.
Cook, C. M., Hallaråker, H., Sæbø, P. C., Innis, S. M., Kelley, K. M., Sanoshy, K. D., ... Maki, K. C. (2016). Bioavailability of long chain omega-3 polyunsaturated fatty acids from phospholipid-rich herring roe oil in men and women with mildly elevated triacylglycerols. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 111, pp. 17-24. doi:10.1016/j.plefa.2016.01.007.
Cook CM, et al. Bioavailability of Long Chain Omega-3 Polyunsaturated Fatty Acids From Phospholipid-rich Herring Roe Oil in Men and Women With Mildly Elevated Triacylglycerols. Prostaglandins Leukot Essent Fatty Acids. 2016;111:17-24. PubMed PMID: 27151222.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bioavailability of long chain omega-3 polyunsaturated fatty acids from phospholipid-rich herring roe oil in men and women with mildly elevated triacylglycerols. AU - Cook,Chad M, AU - Hallaråker,Hogne, AU - Sæbø,Per Christian, AU - Innis,Sheila M, AU - Kelley,Kathleen M, AU - Sanoshy,Kristen D, AU - Berger,Alvin, AU - Maki,Kevin C, Y1 - 2016/03/04/ PY - 2015/07/20/received PY - 2016/01/06/revised PY - 2016/01/12/accepted PY - 2016/5/7/entrez PY - 2016/5/7/pubmed PY - 2017/11/29/medline KW - DHA KW - EPA KW - Omega-3 fatty acids KW - fish oil KW - phosphatidylcholine SP - 17 EP - 24 JF - Prostaglandins, leukotrienes, and essential fatty acids JO - Prostaglandins Leukot. Essent. Fatty Acids VL - 111 N2 - This randomized, single-blind, crossover trial assessed the bioavailability of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and docosapentaenoic acid (DPA) from two different sources, each examined over a 12h period following consumption of a single serving and after 2-weeks of daily supplementation. Thirty-two adults with fasting triacylglycerol (TAG) concentrations between 100 and 399mg/dL were randomly assigned, with stratification by sex and age, to receive 12 capsules/day containing either phospholipid (PL)-rich herring roe oil (Romega® 30, 628mg/day EPA; 1810mg/day DHA; 137mg/day DPA) or TAG-rich fish oil (575mg/day EPA; 1843mg/day DHA; 259mg/day DPA) each for a 2-week period separated by a 4 week washout. The net incremental area under the curve from 0 to 12h for EPA, DHA, and EPA+DHA in plasma phosphatidylcholine (PC) were significantly higher (p<0.01 for all) after Romega 30 supplementation compared to fish oil. Similar results were observed when the data for the Romega 30 condition were normalized to fish oil EPA and DHA intakes (p<0.001 for all). After the 2-week supplementation period, fasting plasma PC EPA+ DHA was elevated by ~2.8 to 3.0-fold relative to baseline in both conditions (p<0.0001 for each), but there was no significant difference in the change from baseline (p=0.422) between Romega 30 (baseline=62.2±3.8µg/mL vs. end of study=172.9±11.7µg/mL) and fish oil (baseline=62.0±3.4µg/mL vs. end of study=185.4±11.2µg/mL) conditions. Similar results were observed for each individual LC n-3 PUFA in plasma PC after 2 weeks of supplementation. These data demonstrate that PL-rich herring roe is a well-tolerated and bioavailable source of LC n-3 PUFA. SN - 1532-2823 UR - https://www.unboundmedicine.com/medline/citation/27151222/Bioavailability_of_long_chain_omega_3_polyunsaturated_fatty_acids_from_phospholipid_rich_herring_roe_oil_in_men_and_women_with_mildly_elevated_triacylglycerols_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0952-3278(15)30011-9 DB - PRIME DP - Unbound Medicine ER -