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The cell biology of CNS myelination.
Curr Opin Neurobiol 2016; 39:93-100CO

Abstract

Myelination of axons in the central nervous system results from the remarkable ability of oligodendrocytes to wrap multiple axons with highly specialized membrane. Because myelin membrane grows as it ensheaths axons, cytoskeletal rearrangements that enable ensheathment must be coordinated with myelin production. Because the myelin sheaths of a single oligodendrocyte can differ in thickness and length, mechanisms that coordinate axon ensheathment with myelin growth likely operate within individual oligodendrocyte processes. Recent studies have revealed new information about how assembly and disassembly of actin filaments helps drive the leading edge of nascent myelin membrane around and along axons. Concurrently, other investigations have begun to uncover evidence of communication between axons and oligodendrocytes that can regulate myelin formation.

Authors+Show Affiliations

Department of Cell and Developmental Biology, University of Colorado School of Medicine, Aurora, CO 80045, United States.Department of Cell and Developmental Biology, University of Colorado School of Medicine, Aurora, CO 80045, United States; Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO 80045, United States. Electronic address: bruce.appel@ucdenver.edu.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

27152449

Citation

Hughes, Ethan G., and Bruce Appel. "The Cell Biology of CNS Myelination." Current Opinion in Neurobiology, vol. 39, 2016, pp. 93-100.
Hughes EG, Appel B. The cell biology of CNS myelination. Curr Opin Neurobiol. 2016;39:93-100.
Hughes, E. G., & Appel, B. (2016). The cell biology of CNS myelination. Current Opinion in Neurobiology, 39, pp. 93-100. doi:10.1016/j.conb.2016.04.013.
Hughes EG, Appel B. The Cell Biology of CNS Myelination. Curr Opin Neurobiol. 2016;39:93-100. PubMed PMID: 27152449.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The cell biology of CNS myelination. AU - Hughes,Ethan G, AU - Appel,Bruce, Y1 - 2016/05/03/ PY - 2016/03/06/received PY - 2016/04/19/revised PY - 2016/04/20/accepted PY - 2016/5/7/entrez PY - 2016/5/7/pubmed PY - 2018/2/17/medline SP - 93 EP - 100 JF - Current opinion in neurobiology JO - Curr. Opin. Neurobiol. VL - 39 N2 - Myelination of axons in the central nervous system results from the remarkable ability of oligodendrocytes to wrap multiple axons with highly specialized membrane. Because myelin membrane grows as it ensheaths axons, cytoskeletal rearrangements that enable ensheathment must be coordinated with myelin production. Because the myelin sheaths of a single oligodendrocyte can differ in thickness and length, mechanisms that coordinate axon ensheathment with myelin growth likely operate within individual oligodendrocyte processes. Recent studies have revealed new information about how assembly and disassembly of actin filaments helps drive the leading edge of nascent myelin membrane around and along axons. Concurrently, other investigations have begun to uncover evidence of communication between axons and oligodendrocytes that can regulate myelin formation. SN - 1873-6882 UR - https://www.unboundmedicine.com/medline/citation/27152449/The_cell_biology_of_CNS_myelination_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0959-4388(16)30048-4 DB - PRIME DP - Unbound Medicine ER -