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An update of the WCRF/AICR systematic literature review on esophageal and gastric cancers and citrus fruits intake.

Abstract

PURPOSE

The 2007 World Cancer Research Fund/American Institute for Cancer Research expert report concluded that foods containing vitamin C probably protect against esophageal cancer and fruits probably protect against gastric cancer. Most of the previous evidence was from case-control studies, which may be affected by recall and selection biases. More recently, several cohort studies have examined these associations. We conducted a systematic literature review of prospective studies on citrus fruits intake and risk of esophageal and gastric cancers.

METHODS

PubMed was searched for studies published until 1 March 2016. We calculated summary relative risks and 95 % confidence intervals (95 % CI) using random-effects models.

RESULTS

With each 100 g/day increase of citrus fruits intake, a marginally significant decreased risk of esophageal cancer was observed (summary RR 0.86, 95 % CI 0.74-1.00, 1,057 cases, six studies). The associations were similar for squamous cell carcinoma (RR 0.87, 95 % CI 0.69-1.08, three studies) and esophageal adenocarcinoma (RR 0.93, 95 % CI 0.78-1.11, three studies). For gastric cancer, the nonsignificant inverse association was observed for gastric cardia cancer (RR 0.75, 95 % CI 0.55-1.01, three studies), but not for gastric non-cardia cancer (RR 1.02, 95 % CI 0.90-1.16, four studies). Consistent summary inverse associations were observed when comparing the highest with lowest intake, with statistically significant associations for esophageal (RR 0.77, 95 % CI 0.64-0.91, seven studies) and gastric cardia cancers (RR 0.62, 95 % CI 0.39-0.99, three studies).

CONCLUSIONS

Citrus fruits may decrease the risk of esophageal and gastric cardia cancers, but further studies are needed.

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  • Authors+Show Affiliations

    ,

    Department of Epidemiology and Biostatistics, Faculty of Medicine, School of Public Health, Imperial College London, St. Mary's Campus, Norfolk Place, London, W2 1PG, UK. s.vingeliene@imperial.ac.uk.

    ,

    Department of Epidemiology and Biostatistics, Faculty of Medicine, School of Public Health, Imperial College London, St. Mary's Campus, Norfolk Place, London, W2 1PG, UK.

    ,

    Department of Epidemiology and Biostatistics, Faculty of Medicine, School of Public Health, Imperial College London, St. Mary's Campus, Norfolk Place, London, W2 1PG, UK. Department of Public Health and General Practice, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway.

    ,

    Department of Epidemiology and Biostatistics, Faculty of Medicine, School of Public Health, Imperial College London, St. Mary's Campus, Norfolk Place, London, W2 1PG, UK.

    ,

    Department of Epidemiology and Biostatistics, Faculty of Medicine, School of Public Health, Imperial College London, St. Mary's Campus, Norfolk Place, London, W2 1PG, UK.

    ,

    Department of Epidemiology and Biostatistics, Faculty of Medicine, School of Public Health, Imperial College London, St. Mary's Campus, Norfolk Place, London, W2 1PG, UK.

    ,

    Department of Epidemiology and Biostatistics, Faculty of Medicine, School of Public Health, Imperial College London, St. Mary's Campus, Norfolk Place, London, W2 1PG, UK.

    ,

    Department of Epidemiology and Biostatistics, Faculty of Medicine, School of Public Health, Imperial College London, St. Mary's Campus, Norfolk Place, London, W2 1PG, UK.

    ,

    Division of Biostatistics, University of Leeds, Leeds, UK.

    Department of Epidemiology and Biostatistics, Faculty of Medicine, School of Public Health, Imperial College London, St. Mary's Campus, Norfolk Place, London, W2 1PG, UK.

    Source

    Cancer causes & control : CCC 27:7 2016 07 pg 837-51

    MeSH

    Adenocarcinoma
    Carcinoma, Squamous Cell
    Case-Control Studies
    Citrus
    Eating
    Esophageal Neoplasms
    Fruit
    Humans
    Prospective Studies
    Stomach Neoplasms

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Review
    Systematic Review

    Language

    eng

    PubMed ID

    27153845

    Citation

    Vingeliene, Snieguole, et al. "An Update of the WCRF/AICR Systematic Literature Review On Esophageal and Gastric Cancers and Citrus Fruits Intake." Cancer Causes & Control : CCC, vol. 27, no. 7, 2016, pp. 837-51.
    Vingeliene S, Chan DS, Aune D, et al. An update of the WCRF/AICR systematic literature review on esophageal and gastric cancers and citrus fruits intake. Cancer Causes Control. 2016;27(7):837-51.
    Vingeliene, S., Chan, D. S., Aune, D., Vieira, A. R., Polemiti, E., Stevens, C., ... Norat, T. (2016). An update of the WCRF/AICR systematic literature review on esophageal and gastric cancers and citrus fruits intake. Cancer Causes & Control : CCC, 27(7), pp. 837-51. doi:10.1007/s10552-016-0755-0.
    Vingeliene S, et al. An Update of the WCRF/AICR Systematic Literature Review On Esophageal and Gastric Cancers and Citrus Fruits Intake. Cancer Causes Control. 2016;27(7):837-51. PubMed PMID: 27153845.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - An update of the WCRF/AICR systematic literature review on esophageal and gastric cancers and citrus fruits intake. AU - Vingeliene,Snieguole, AU - Chan,Doris S M, AU - Aune,Dagfinn, AU - Vieira,Ana R, AU - Polemiti,Elli, AU - Stevens,Christophe, AU - Abar,Leila, AU - Rosenblatt,Deborah Navarro, AU - Greenwood,Darren C, AU - Norat,Teresa, Y1 - 2016/05/06/ PY - 2015/05/14/received PY - 2016/04/27/accepted PY - 2016/5/8/entrez PY - 2016/5/8/pubmed PY - 2017/2/6/medline KW - Citrus fruits KW - Esophageal cancer KW - Gastric cancer KW - Meta-analysis KW - Systematic literature review SP - 837 EP - 51 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 27 IS - 7 N2 - PURPOSE: The 2007 World Cancer Research Fund/American Institute for Cancer Research expert report concluded that foods containing vitamin C probably protect against esophageal cancer and fruits probably protect against gastric cancer. Most of the previous evidence was from case-control studies, which may be affected by recall and selection biases. More recently, several cohort studies have examined these associations. We conducted a systematic literature review of prospective studies on citrus fruits intake and risk of esophageal and gastric cancers. METHODS: PubMed was searched for studies published until 1 March 2016. We calculated summary relative risks and 95 % confidence intervals (95 % CI) using random-effects models. RESULTS: With each 100 g/day increase of citrus fruits intake, a marginally significant decreased risk of esophageal cancer was observed (summary RR 0.86, 95 % CI 0.74-1.00, 1,057 cases, six studies). The associations were similar for squamous cell carcinoma (RR 0.87, 95 % CI 0.69-1.08, three studies) and esophageal adenocarcinoma (RR 0.93, 95 % CI 0.78-1.11, three studies). For gastric cancer, the nonsignificant inverse association was observed for gastric cardia cancer (RR 0.75, 95 % CI 0.55-1.01, three studies), but not for gastric non-cardia cancer (RR 1.02, 95 % CI 0.90-1.16, four studies). Consistent summary inverse associations were observed when comparing the highest with lowest intake, with statistically significant associations for esophageal (RR 0.77, 95 % CI 0.64-0.91, seven studies) and gastric cardia cancers (RR 0.62, 95 % CI 0.39-0.99, three studies). CONCLUSIONS: Citrus fruits may decrease the risk of esophageal and gastric cardia cancers, but further studies are needed. SN - 1573-7225 UR - https://www.unboundmedicine.com/medline/citation/27153845/full_citation L2 - https://doi.org/10.1007/s10552-016-0755-0 DB - PRIME DP - Unbound Medicine ER -