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Gut Immunity and Type 1 Diabetes: a Mélange of Microbes, Diet, and Host Interactions?
Curr Diab Rep. 2016 07; 16(7):60.CD

Abstract

Type 1 diabetes (T1D) is a complex autoimmune disease, and first stages of the disease typically develop early in life. Genetic as well as environmental factors are thought to contribute to the risk of developing autoimmunity against pancreatic beta cells. Several environmental factors, such as breastfeeding or early introduction of solid food, have been associated with increased risk for developing T1D. During the first years of life, the gut microbial community is shaped by the environment, in particular by dietary factors. Moreover, the gut microbiome has been described for its role in shaping the immune system early in life and early data suggest associations between T1D risk and alterations in gut microbial communities. In this article, we discuss environmental factors influencing the colonization process of the gut microbial community. Furthermore, we review possible interactions between the microbiome and the host that might contribute to the risk of developing T1D.

Authors+Show Affiliations

Scientific Computing Research Unit, Helmholtz Zentrum München, Ingolstaedter Landstrasse 1, 85764, Neuherberg, Germany. david.endesfelder@helmholtz-muenchen.de.Scientific Computing Research Unit, Helmholtz Zentrum München, Ingolstaedter Landstrasse 1, 85764, Neuherberg, Germany.Department of Mathematics, Technische Universität München, Boltzmannstrasse 3, 85747, Garching, Germany.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

27155610

Citation

Endesfelder, David, et al. "Gut Immunity and Type 1 Diabetes: a Mélange of Microbes, Diet, and Host Interactions?" Current Diabetes Reports, vol. 16, no. 7, 2016, p. 60.
Endesfelder D, Engel M, Zu Castell W. Gut Immunity and Type 1 Diabetes: a Mélange of Microbes, Diet, and Host Interactions? Curr Diab Rep. 2016;16(7):60.
Endesfelder, D., Engel, M., & Zu Castell, W. (2016). Gut Immunity and Type 1 Diabetes: a Mélange of Microbes, Diet, and Host Interactions? Current Diabetes Reports, 16(7), 60. https://doi.org/10.1007/s11892-016-0753-3
Endesfelder D, Engel M, Zu Castell W. Gut Immunity and Type 1 Diabetes: a Mélange of Microbes, Diet, and Host Interactions. Curr Diab Rep. 2016;16(7):60. PubMed PMID: 27155610.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gut Immunity and Type 1 Diabetes: a Mélange of Microbes, Diet, and Host Interactions? AU - Endesfelder,David, AU - Engel,Marion, AU - Zu Castell,Wolfgang, PY - 2016/5/9/entrez PY - 2016/5/10/pubmed PY - 2017/5/10/medline KW - Autoimmunity KW - Diet KW - Environmental factors KW - Gut microbiome KW - Type 1 diabetes SP - 60 EP - 60 JF - Current diabetes reports JO - Curr. Diab. Rep. VL - 16 IS - 7 N2 - Type 1 diabetes (T1D) is a complex autoimmune disease, and first stages of the disease typically develop early in life. Genetic as well as environmental factors are thought to contribute to the risk of developing autoimmunity against pancreatic beta cells. Several environmental factors, such as breastfeeding or early introduction of solid food, have been associated with increased risk for developing T1D. During the first years of life, the gut microbial community is shaped by the environment, in particular by dietary factors. Moreover, the gut microbiome has been described for its role in shaping the immune system early in life and early data suggest associations between T1D risk and alterations in gut microbial communities. In this article, we discuss environmental factors influencing the colonization process of the gut microbial community. Furthermore, we review possible interactions between the microbiome and the host that might contribute to the risk of developing T1D. SN - 1539-0829 UR - https://www.unboundmedicine.com/medline/citation/27155610/Gut_Immunity_and_Type_1_Diabetes:_a_Mélange_of_Microbes_Diet_and_Host_Interactions L2 - https://dx.doi.org/10.1007/s11892-016-0753-3 DB - PRIME DP - Unbound Medicine ER -