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Wolbachia Blocks Currently Circulating Zika Virus Isolates in Brazilian Aedes aegypti Mosquitoes.
Cell Host Microbe. 2016 Jun 08; 19(6):771-4.CH

Abstract

The recent association of Zika virus with cases of microcephaly has sparked a global health crisis and highlighted the need for mechanisms to combat the Zika vector, Aedes aegypti mosquitoes. Wolbachia pipientis, a bacterial endosymbiont of insect, has recently garnered attention as a mechanism for arbovirus control. Here we report that Aedes aegypti harboring Wolbachia are highly resistant to infection with two currently circulating Zika virus isolates from the recent Brazilian epidemic. Wolbachia-harboring mosquitoes displayed lower viral prevalence and intensity and decreased disseminated infection and, critically, did not carry infectious virus in the saliva, suggesting that viral transmission was blocked. Our data indicate that the use of Wolbachia-harboring mosquitoes could represent an effective mechanism to reduce Zika virus transmission and should be included as part of Zika control strategies.

Authors+Show Affiliations

Mosquitos Vetores: Endossimbiontes e Interação Patógeno-Vetor, Centro de Pesquisas René Rachou-Fiocruz, Belo Horizonte, MG, 30190-002, Brazil.Mosquitos Vetores: Endossimbiontes e Interação Patógeno-Vetor, Centro de Pesquisas René Rachou-Fiocruz, Belo Horizonte, MG, 30190-002, Brazil.Mosquitos Vetores: Endossimbiontes e Interação Patógeno-Vetor, Centro de Pesquisas René Rachou-Fiocruz, Belo Horizonte, MG, 30190-002, Brazil; Plataforma de Vetores de Doenças-Fiocruz, CE, 60190-800, Brazil.Mosquitos Vetores: Endossimbiontes e Interação Patógeno-Vetor, Centro de Pesquisas René Rachou-Fiocruz, Belo Horizonte, MG, 30190-002, Brazil.Mosquitos Vetores: Endossimbiontes e Interação Patógeno-Vetor, Centro de Pesquisas René Rachou-Fiocruz, Belo Horizonte, MG, 30190-002, Brazil.Mosquitos Vetores: Endossimbiontes e Interação Patógeno-Vetor, Centro de Pesquisas René Rachou-Fiocruz, Belo Horizonte, MG, 30190-002, Brazil. Electronic address: luciano@cpqrr.fiocruz.br.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27156023

Citation

Dutra, Heverton Leandro Carneiro, et al. "Wolbachia Blocks Currently Circulating Zika Virus Isolates in Brazilian Aedes Aegypti Mosquitoes." Cell Host & Microbe, vol. 19, no. 6, 2016, pp. 771-4.
Dutra HL, Rocha MN, Dias FB, et al. Wolbachia Blocks Currently Circulating Zika Virus Isolates in Brazilian Aedes aegypti Mosquitoes. Cell Host Microbe. 2016;19(6):771-4.
Dutra, H. L., Rocha, M. N., Dias, F. B., Mansur, S. B., Caragata, E. P., & Moreira, L. A. (2016). Wolbachia Blocks Currently Circulating Zika Virus Isolates in Brazilian Aedes aegypti Mosquitoes. Cell Host & Microbe, 19(6), 771-4. https://doi.org/10.1016/j.chom.2016.04.021
Dutra HL, et al. Wolbachia Blocks Currently Circulating Zika Virus Isolates in Brazilian Aedes Aegypti Mosquitoes. Cell Host Microbe. 2016 Jun 8;19(6):771-4. PubMed PMID: 27156023.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Wolbachia Blocks Currently Circulating Zika Virus Isolates in Brazilian Aedes aegypti Mosquitoes. AU - Dutra,Heverton Leandro Carneiro, AU - Rocha,Marcele Neves, AU - Dias,Fernando Braga Stehling, AU - Mansur,Simone Brutman, AU - Caragata,Eric Pearce, AU - Moreira,Luciano Andrade, Y1 - 2016/05/04/ PY - 2016/04/15/received PY - 2016/04/26/revised PY - 2016/04/26/accepted PY - 2016/5/9/entrez PY - 2016/5/9/pubmed PY - 2017/9/22/medline SP - 771 EP - 4 JF - Cell host & microbe JO - Cell Host Microbe VL - 19 IS - 6 N2 - The recent association of Zika virus with cases of microcephaly has sparked a global health crisis and highlighted the need for mechanisms to combat the Zika vector, Aedes aegypti mosquitoes. Wolbachia pipientis, a bacterial endosymbiont of insect, has recently garnered attention as a mechanism for arbovirus control. Here we report that Aedes aegypti harboring Wolbachia are highly resistant to infection with two currently circulating Zika virus isolates from the recent Brazilian epidemic. Wolbachia-harboring mosquitoes displayed lower viral prevalence and intensity and decreased disseminated infection and, critically, did not carry infectious virus in the saliva, suggesting that viral transmission was blocked. Our data indicate that the use of Wolbachia-harboring mosquitoes could represent an effective mechanism to reduce Zika virus transmission and should be included as part of Zika control strategies. SN - 1934-6069 UR - https://www.unboundmedicine.com/medline/citation/27156023/Wolbachia_Blocks_Currently_Circulating_Zika_Virus_Isolates_in_Brazilian_Aedes_aegypti_Mosquitoes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1931-3128(16)30157-3 DB - PRIME DP - Unbound Medicine ER -