Tags

Type your tag names separated by a space and hit enter

Polycystic ovary syndrome: Endometrial markers.

Abstract

Women with polycystic ovarian syndrome (PCOS) present with several endometrial abnormalities possibly explaining some of the adverse endometrium-related outcomes in these women. PCOS and an increased miscarriage rate have been suggested to coincide, but the results are conflicting. Recent studies have also shown increased risks of pregnancy-induced hypertension, preeclampsia, and premature delivery that may be related to altered decidualization/placentation in affected women. In the long run, PCOS per se is associated with the occurrence of endometrial cancer (EC), with obesity aggravating the risk. Most investigated markers of the endometrial abnormalities in women with PCOS are related to steroid hormone action (ERs (estrogen receptors), PRs (progesterone receptors), ARs (androgen receptors), and steroid receptor coactivators), endometrial receptivity/decidualization (HOXA10, αvβ3 integrin, and IGFBP-1 (insulin-like growth factor-binding protein 1)), glucose metabolism (IRs (insulin receptors), glucose transporters, IGFs) and inflammation/immune cell migration ((IL-6 (interleukin 6), CCL2 (CC motif ligand), and uNK (uterine natural killer) cells). Despite several endometrial abnormalities in women with PCOS, the clinical relevance of these findings still awaits future clarification; to date, no common screening protocols/recommendations for women with PCOS have been established.

Authors+Show Affiliations

Clinical Researcher for the Finnish Medical Foundation, Department of Obstetrics and Gynecology, PEDEGO Research Unit, Medical Research Center, Oulu University Hospital, University of Oulu, Kajaanintie 50, BOX 5000, 90014 Oulu, Finland. Electronic address: terhi.piltonen@oulu.fi.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

27156350

Citation

Piltonen, Terhi T.. "Polycystic Ovary Syndrome: Endometrial Markers." Best Practice & Research. Clinical Obstetrics & Gynaecology, vol. 37, 2016, pp. 66-79.
Piltonen TT. Polycystic ovary syndrome: Endometrial markers. Best Pract Res Clin Obstet Gynaecol. 2016;37:66-79.
Piltonen, T. T. (2016). Polycystic ovary syndrome: Endometrial markers. Best Practice & Research. Clinical Obstetrics & Gynaecology, 37, 66-79. https://doi.org/10.1016/j.bpobgyn.2016.03.008
Piltonen TT. Polycystic Ovary Syndrome: Endometrial Markers. Best Pract Res Clin Obstet Gynaecol. 2016;37:66-79. PubMed PMID: 27156350.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Polycystic ovary syndrome: Endometrial markers. A1 - Piltonen,Terhi T, Y1 - 2016/04/01/ PY - 2016/02/07/received PY - 2016/03/05/accepted PY - 2016/5/10/pubmed PY - 2017/3/16/medline PY - 2016/5/10/entrez KW - PCOS KW - endometrial cancer KW - endometrium KW - hyperinsulinemia KW - inflammation KW - pregnancy complications SP - 66 EP - 79 JF - Best practice & research. Clinical obstetrics & gynaecology JO - Best Pract Res Clin Obstet Gynaecol VL - 37 N2 - Women with polycystic ovarian syndrome (PCOS) present with several endometrial abnormalities possibly explaining some of the adverse endometrium-related outcomes in these women. PCOS and an increased miscarriage rate have been suggested to coincide, but the results are conflicting. Recent studies have also shown increased risks of pregnancy-induced hypertension, preeclampsia, and premature delivery that may be related to altered decidualization/placentation in affected women. In the long run, PCOS per se is associated with the occurrence of endometrial cancer (EC), with obesity aggravating the risk. Most investigated markers of the endometrial abnormalities in women with PCOS are related to steroid hormone action (ERs (estrogen receptors), PRs (progesterone receptors), ARs (androgen receptors), and steroid receptor coactivators), endometrial receptivity/decidualization (HOXA10, αvβ3 integrin, and IGFBP-1 (insulin-like growth factor-binding protein 1)), glucose metabolism (IRs (insulin receptors), glucose transporters, IGFs) and inflammation/immune cell migration ((IL-6 (interleukin 6), CCL2 (CC motif ligand), and uNK (uterine natural killer) cells). Despite several endometrial abnormalities in women with PCOS, the clinical relevance of these findings still awaits future clarification; to date, no common screening protocols/recommendations for women with PCOS have been established. SN - 1532-1932 UR - https://www.unboundmedicine.com/medline/citation/27156350/Polycystic_ovary_syndrome:_Endometrial_markers_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1521-6934(16)30007-4 DB - PRIME DP - Unbound Medicine ER -