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Altered NR4A Subfamily Gene Expression Level in Peripheral Blood of Parkinson's and Alzheimer's Disease Patients.
Neurotox Res. 2016 10; 30(3):338-44.NR

Abstract

Parkinson's disease (PD) is a neurodegenerative pathology characterized by the degeneration of midbrain dopamine neurons, whose development and maintenance in brain is related to the transcription factor NR4A2 (also called Nurr1). Notably, NR4A2 is a neuroprotective agent with anti-inflammatory role in microglia and astrocytes. Furthermore, mutations in NR4A2 gene are associated to the familial form of PD, and its gene expression level is down-regulated in blood obtained from PD patients. NR4A2 belongs to the NR4A subfamily consisting of three members: NR4A1, NR4A2, and NR4A3. The NR4A subfamily shares high degree of homology in their molecular structure and cooperates in a spectrum of functions ranging from central nervous system to immune control during physiological and pathological conditions. Considering the close functional link between the member of NR4A subfamily, we performed a gene expression analysis of NR4A1, NR4A2, and NR4A3 in peripheral blood obtained from PD patients and healthy controls (HC). Then, in order to evaluate possible involvement of the NR4A subfamily in other neurodegenerative processes, we carried out the same analysis on blood obtained from Alzheimer's disease (AD) patients. A correlation between clinical features and gene expression was also evaluated. We found a marked down-regulated gene expression of the NR4A subfamily obtained from PD patients, but only a NR4A1 decrease in AD patients compared to HC. This study reports that the entire NR4A subfamily and not only NR4A2 could be systemically involved in PD suggesting that the study of these factors could be a promising approach to develop PD therapy.

Authors+Show Affiliations

Neurobiology Unit, Neurologia 2 - CReSM (Regional Referring Center of Multiple Sclerosis), Neuroscience Institute Cavalieri Ottolenghi (NICO), University of Turin & AOU San Luigi Gonzaga, Regione Gonzole, 10, 10043, Orbassano, TO, Italy. francesca.montarolo@unito.it.Neurobiology Unit, Neurologia 2 - CReSM (Regional Referring Center of Multiple Sclerosis), Neuroscience Institute Cavalieri Ottolenghi (NICO), University of Turin & AOU San Luigi Gonzaga, Regione Gonzole, 10, 10043, Orbassano, TO, Italy.Neurobiology Unit, Neurologia 2 - CReSM (Regional Referring Center of Multiple Sclerosis), Neuroscience Institute Cavalieri Ottolenghi (NICO), University of Turin & AOU San Luigi Gonzaga, Regione Gonzole, 10, 10043, Orbassano, TO, Italy.Neurobiology Unit, Neurologia 2 - CReSM (Regional Referring Center of Multiple Sclerosis), Neuroscience Institute Cavalieri Ottolenghi (NICO), University of Turin & AOU San Luigi Gonzaga, Regione Gonzole, 10, 10043, Orbassano, TO, Italy.Division of Neurology, Martini Hospital, Via Tofane, 71, 10141, Turin, TO, Italy.Division of Neurology, Martini Hospital, Via Tofane, 71, 10141, Turin, TO, Italy.Neurobiology Unit, Neurologia 2 - CReSM (Regional Referring Center of Multiple Sclerosis), Neuroscience Institute Cavalieri Ottolenghi (NICO), University of Turin & AOU San Luigi Gonzaga, Regione Gonzole, 10, 10043, Orbassano, TO, Italy.

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27159982

Citation

Montarolo, Francesca, et al. "Altered NR4A Subfamily Gene Expression Level in Peripheral Blood of Parkinson's and Alzheimer's Disease Patients." Neurotoxicity Research, vol. 30, no. 3, 2016, pp. 338-44.
Montarolo F, Perga S, Martire S, et al. Altered NR4A Subfamily Gene Expression Level in Peripheral Blood of Parkinson's and Alzheimer's Disease Patients. Neurotox Res. 2016;30(3):338-44.
Montarolo, F., Perga, S., Martire, S., Navone, D. N., Marchet, A., Leotta, D., & Bertolotto, A. (2016). Altered NR4A Subfamily Gene Expression Level in Peripheral Blood of Parkinson's and Alzheimer's Disease Patients. Neurotoxicity Research, 30(3), 338-44. https://doi.org/10.1007/s12640-016-9626-4
Montarolo F, et al. Altered NR4A Subfamily Gene Expression Level in Peripheral Blood of Parkinson's and Alzheimer's Disease Patients. Neurotox Res. 2016;30(3):338-44. PubMed PMID: 27159982.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Altered NR4A Subfamily Gene Expression Level in Peripheral Blood of Parkinson's and Alzheimer's Disease Patients. AU - Montarolo,Francesca, AU - Perga,Simona, AU - Martire,Serena, AU - Navone,Désirée Nicole, AU - Marchet,Alberto, AU - Leotta,Daniela, AU - Bertolotto,Antonio, Y1 - 2016/05/09/ PY - 2016/02/20/received PY - 2016/04/20/accepted PY - 2016/04/05/revised PY - 2016/5/11/entrez PY - 2016/5/11/pubmed PY - 2017/7/27/medline KW - Alzheimer’s disease KW - NR4A subfamily KW - Neurodegenerative diseases KW - Nurr1 KW - Parkinson’s disease SP - 338 EP - 44 JF - Neurotoxicity research JO - Neurotox Res VL - 30 IS - 3 N2 - Parkinson's disease (PD) is a neurodegenerative pathology characterized by the degeneration of midbrain dopamine neurons, whose development and maintenance in brain is related to the transcription factor NR4A2 (also called Nurr1). Notably, NR4A2 is a neuroprotective agent with anti-inflammatory role in microglia and astrocytes. Furthermore, mutations in NR4A2 gene are associated to the familial form of PD, and its gene expression level is down-regulated in blood obtained from PD patients. NR4A2 belongs to the NR4A subfamily consisting of three members: NR4A1, NR4A2, and NR4A3. The NR4A subfamily shares high degree of homology in their molecular structure and cooperates in a spectrum of functions ranging from central nervous system to immune control during physiological and pathological conditions. Considering the close functional link between the member of NR4A subfamily, we performed a gene expression analysis of NR4A1, NR4A2, and NR4A3 in peripheral blood obtained from PD patients and healthy controls (HC). Then, in order to evaluate possible involvement of the NR4A subfamily in other neurodegenerative processes, we carried out the same analysis on blood obtained from Alzheimer's disease (AD) patients. A correlation between clinical features and gene expression was also evaluated. We found a marked down-regulated gene expression of the NR4A subfamily obtained from PD patients, but only a NR4A1 decrease in AD patients compared to HC. This study reports that the entire NR4A subfamily and not only NR4A2 could be systemically involved in PD suggesting that the study of these factors could be a promising approach to develop PD therapy. SN - 1476-3524 UR - https://www.unboundmedicine.com/medline/citation/27159982/Altered_NR4A_Subfamily_Gene_Expression_Level_in_Peripheral_Blood_of_Parkinson's_and_Alzheimer's_Disease_Patients_ L2 - https://dx.doi.org/10.1007/s12640-016-9626-4 DB - PRIME DP - Unbound Medicine ER -