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Role of TRPC Channels in Store-Operated Calcium Entry.
Adv Exp Med Biol. 2016; 898:87-109.AE

Abstract

Store-operated calcium entry (SOCE) is a ubiquitous Ca(2+) entry pathway that is activated in response to depletion of Ca(2+) stores within the endoplasmic reticulum (ER) and contributes to the control of various physiological functions in a wide variety of cell types. The transient receptor potential canonical (TRPC) channels (TRPCs 1-7), that are activated by stimuli leading to PIP2 hydrolysis, were first identified as molecular components of SOCE channels. TRPC channels show a miscellany of tissue expression, physiological functions and channel properties. However, none of the TRPC members display currents that resemble I CRAC. Intensive search for the CRAC channel component led to identification of Orai1 and STIM1, now established as being the primary constituents of the CRAC channel. There is now considerable evidence that STIM1 activates both Orai1 and TRPC1 via distinct domains in its C-terminus. Intriguingly, TRPC1 function is not only dependent on STIM1 but also requires Orai1. The critical functional interaction between TRPC1 and Orai1, which determines the activation of TRPC1, has also been identified. In this review, we will discuss current concepts regarding the role of TRPC channels in SOCE, the physiological functions regulated by TRPC-mediated SOCE, and the complex mechanisms underlying the regulation of TRPCs, including the functional interactions with Orai1 and STIM1.

Authors+Show Affiliations

Secretory Physiology Section, Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Building 10, Room 1N-113, NIH, Bethesda, MD, 20892, USA. ongh@mail.nih.gov.Secretory Physiology Section, Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Building 10, Room 1N-113, NIH, Bethesda, MD, 20892, USA.Secretory Physiology Section, Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Building 10, Room 1N-113, NIH, Bethesda, MD, 20892, USA. indu.ambudkar@nih.gov.

Pub Type(s)

Journal Article
Research Support, N.I.H., Intramural
Review

Language

eng

PubMed ID

27161226

Citation

Ong, Hwei Ling, et al. "Role of TRPC Channels in Store-Operated Calcium Entry." Advances in Experimental Medicine and Biology, vol. 898, 2016, pp. 87-109.
Ong HL, de Souza LB, Ambudkar IS. Role of TRPC Channels in Store-Operated Calcium Entry. Adv Exp Med Biol. 2016;898:87-109.
Ong, H. L., de Souza, L. B., & Ambudkar, I. S. (2016). Role of TRPC Channels in Store-Operated Calcium Entry. Advances in Experimental Medicine and Biology, 898, 87-109. https://doi.org/10.1007/978-3-319-26974-0_5
Ong HL, de Souza LB, Ambudkar IS. Role of TRPC Channels in Store-Operated Calcium Entry. Adv Exp Med Biol. 2016;898:87-109. PubMed PMID: 27161226.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of TRPC Channels in Store-Operated Calcium Entry. AU - Ong,Hwei Ling, AU - de Souza,Lorena Brito, AU - Ambudkar,Indu S, PY - 2016/5/11/entrez PY - 2016/5/11/pubmed PY - 2016/9/10/medline KW - Function KW - SOCE KW - TRPC channels KW - Trafficking SP - 87 EP - 109 JF - Advances in experimental medicine and biology JO - Adv Exp Med Biol VL - 898 N2 - Store-operated calcium entry (SOCE) is a ubiquitous Ca(2+) entry pathway that is activated in response to depletion of Ca(2+) stores within the endoplasmic reticulum (ER) and contributes to the control of various physiological functions in a wide variety of cell types. The transient receptor potential canonical (TRPC) channels (TRPCs 1-7), that are activated by stimuli leading to PIP2 hydrolysis, were first identified as molecular components of SOCE channels. TRPC channels show a miscellany of tissue expression, physiological functions and channel properties. However, none of the TRPC members display currents that resemble I CRAC. Intensive search for the CRAC channel component led to identification of Orai1 and STIM1, now established as being the primary constituents of the CRAC channel. There is now considerable evidence that STIM1 activates both Orai1 and TRPC1 via distinct domains in its C-terminus. Intriguingly, TRPC1 function is not only dependent on STIM1 but also requires Orai1. The critical functional interaction between TRPC1 and Orai1, which determines the activation of TRPC1, has also been identified. In this review, we will discuss current concepts regarding the role of TRPC channels in SOCE, the physiological functions regulated by TRPC-mediated SOCE, and the complex mechanisms underlying the regulation of TRPCs, including the functional interactions with Orai1 and STIM1. SN - 0065-2598 UR - https://www.unboundmedicine.com/medline/citation/27161226/Role_of_TRPC_Channels_in_Store_Operated_Calcium_Entry_ L2 - https://dx.doi.org/10.1007/978-3-319-26974-0_5 DB - PRIME DP - Unbound Medicine ER -