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Auto-brewery Syndrome in the Setting of Long-standing Crohn's Disease: A Case Report and Review of the Literature.
J Crohns Colitis. 2016 Dec; 10(12):1448-1450.JC

Abstract

CLINICAL BACKGROUND

A 71-year-old male with 50-year history of Crohn's disease was evaluated for acute onset of dizziness and slurred speech. Blood ethanol levels were elevated despite abstinence from alcohol for over 30 years. CT enterography demonstrated massive dilation of the small bowel with anastomotic stricture.

DISCUSSION

Auto-brewery syndrome may be considered in a patient with chronic obstruction or hypomotility presenting with elevated serum ethanol levels in the setting of high carbohydrate intake. Although treatment algorithms lack validation, judicious use of antibiotic therapy, carbohydrate control, and short courses of antifungal therapy have all been reported in the literature. Importantly, clinical consideration of 'auto-brewery' should be undertaken with substantial caution, given the lack of validated mechanisms linking endogenous ethanol production to peripheral blood ethanol.

Authors+Show Affiliations

Mayo Clinic Department of Radiology, Rochester, MN, USA welch.brian@mayo.edu.Mayo Clinic Department of Gastroenterology and Hepatology, Rochester, MN, USA.Mayo Clinic Department of Radiology, Rochester, MN, USA.Mayo Clinic Department of Radiology, Rochester, MN, USA.

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

27161390

Citation

Welch, B T., et al. "Auto-brewery Syndrome in the Setting of Long-standing Crohn's Disease: a Case Report and Review of the Literature." Journal of Crohn's & Colitis, vol. 10, no. 12, 2016, pp. 1448-1450.
Welch BT, Coelho Prabhu N, Walkoff L, et al. Auto-brewery Syndrome in the Setting of Long-standing Crohn's Disease: A Case Report and Review of the Literature. J Crohns Colitis. 2016;10(12):1448-1450.
Welch, B. T., Coelho Prabhu, N., Walkoff, L., & Trenkner, S. W. (2016). Auto-brewery Syndrome in the Setting of Long-standing Crohn's Disease: A Case Report and Review of the Literature. Journal of Crohn's & Colitis, 10(12), 1448-1450.
Welch BT, et al. Auto-brewery Syndrome in the Setting of Long-standing Crohn's Disease: a Case Report and Review of the Literature. J Crohns Colitis. 2016;10(12):1448-1450. PubMed PMID: 27161390.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Auto-brewery Syndrome in the Setting of Long-standing Crohn's Disease: A Case Report and Review of the Literature. AU - Welch,B T, AU - Coelho Prabhu,N, AU - Walkoff,L, AU - Trenkner,S W, Y1 - 2016/05/09/ PY - 2016/04/30/received PY - 2016/05/04/accepted PY - 2016/5/11/pubmed PY - 2017/6/3/medline PY - 2016/5/11/entrez SP - 1448 EP - 1450 JF - Journal of Crohn's & colitis JO - J Crohns Colitis VL - 10 IS - 12 N2 - CLINICAL BACKGROUND: A 71-year-old male with 50-year history of Crohn's disease was evaluated for acute onset of dizziness and slurred speech. Blood ethanol levels were elevated despite abstinence from alcohol for over 30 years. CT enterography demonstrated massive dilation of the small bowel with anastomotic stricture. DISCUSSION: Auto-brewery syndrome may be considered in a patient with chronic obstruction or hypomotility presenting with elevated serum ethanol levels in the setting of high carbohydrate intake. Although treatment algorithms lack validation, judicious use of antibiotic therapy, carbohydrate control, and short courses of antifungal therapy have all been reported in the literature. Importantly, clinical consideration of 'auto-brewery' should be undertaken with substantial caution, given the lack of validated mechanisms linking endogenous ethanol production to peripheral blood ethanol. SN - 1876-4479 UR - https://www.unboundmedicine.com/medline/citation/27161390/Auto_brewery_Syndrome_in_the_Setting_of_Long_standing_Crohn's_Disease:_A_Case_Report_and_Review_of_the_Literature_ L2 - https://academic.oup.com/ecco-jcc/article-lookup/doi/10.1093/ecco-jcc/jjw098 DB - PRIME DP - Unbound Medicine ER -