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Development and validation of quality of life scale of nasopharyngeal carcinoma patients: the QOL-NPC (version 2).
Health Qual Life Outcomes. 2016 May 10; 14:76.HQ

Abstract

BACKGROUND

The aim was to develop and validate the quality of life scale for nasopharyngeal carcinoma (NPC) patients, the QOL-NPC (version 2), a specific instrument to measure quality of life for NPC patients.

METHODS

The QOL-NPC was developed and validated according to standard procedures. The patients were assessed using the QOL-NPC, FACT-G, and FACT-H&N. Classical test theory was used to evaluate the reliability, validity, and responsiveness of the QOL-NPC.

RESULTS

A total of 487 patients (97.4 %) completed the questionnaire. The QOL-NPC comprised four domains, as follows: physical function (eight items); psychological function (five items); social function (five items); and side effects (eight items). All of the items had a lower proportion of missing data. Cronbach's alpha values of the domains ranged from 0.72 to 0.84. The split-half reliability coefficients ranged from 0.77 to 0.84. All of the intra-class correlation coefficients were > 0.8. The normed fit index, non-normed fit index, and comparative fit index were >0.89. The root mean square error of approximation was 0.097, with a 90 % confidence interval (0.093, 0.100). The domain scores of the QOL-NPC were significantly correlated with the FACT-G and FACT-H&N (P < 0.05). All of the domain scores of patients using different amounts of radiotherapy were significantly different (P < 0.001). All domain scores decreased at the completion of radiotherapy, with effect sizes ranging from -0.82 to -0.22.

CONCLUSIONS

The QOL-NPC is valid for measuring QOL with good reliability, validity, and responsiveness. The QOL-NPC is recommended to measure the QOL for Chinese NPC patients.

Authors+Show Affiliations

Department of Radiation Oncology, Cancer Centre, Sun Yat-sen University, Guangzhou, Guangdong Province, China. Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Guangzhou, Guangdong Province, China.Department of Biostatistics and Preventive Medicine, School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China.Department of Radiation Oncology, Cancer Centre, Sun Yat-sen University, Guangzhou, Guangdong Province, China. Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Guangzhou, Guangdong Province, China.Department of Radiation Oncology, Cancer Centre, Sun Yat-sen University, Guangzhou, Guangdong Province, China. Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Guangzhou, Guangdong Province, China.Department of Biostatistics and Preventive Medicine, School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China.School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China.School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China.Department of Radiation Oncology, Cancer Centre, Sun Yat-sen University, Guangzhou, Guangdong Province, China.Department of Biostatistics and Preventive Medicine, School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China. chenxlsums@126.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Validation Study

Language

eng

PubMed ID

27164979

Citation

Su, Yong, et al. "Development and Validation of Quality of Life Scale of Nasopharyngeal Carcinoma Patients: the QOL-NPC (version 2)." Health and Quality of Life Outcomes, vol. 14, 2016, p. 76.
Su Y, Mo CW, Cheng WQ, et al. Development and validation of quality of life scale of nasopharyngeal carcinoma patients: the QOL-NPC (version 2). Health Qual Life Outcomes. 2016;14:76.
Su, Y., Mo, C. W., Cheng, W. Q., Wang, L., Xu, Q., Wu, Z. C., Wu, Z. L., Liu, L. Z., & Chen, X. L. (2016). Development and validation of quality of life scale of nasopharyngeal carcinoma patients: the QOL-NPC (version 2). Health and Quality of Life Outcomes, 14, 76. https://doi.org/10.1186/s12955-016-0480-0
Su Y, et al. Development and Validation of Quality of Life Scale of Nasopharyngeal Carcinoma Patients: the QOL-NPC (version 2). Health Qual Life Outcomes. 2016 May 10;14:76. PubMed PMID: 27164979.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Development and validation of quality of life scale of nasopharyngeal carcinoma patients: the QOL-NPC (version 2). AU - Su,Yong, AU - Mo,Chuan-Wei, AU - Cheng,Wan-Qin, AU - Wang,Lei, AU - Xu,Qian, AU - Wu,Zu-Chun, AU - Wu,Zhe-Li, AU - Liu,Li-Zhi, AU - Chen,Xin-Lin, Y1 - 2016/05/10/ PY - 2015/12/02/received PY - 2016/05/03/accepted PY - 2016/5/12/entrez PY - 2016/5/12/pubmed PY - 2016/11/15/medline KW - Health-related quality of life KW - QOL-NPC KW - Reliability KW - Responsiveness KW - Validity SP - 76 EP - 76 JF - Health and quality of life outcomes JO - Health Qual Life Outcomes VL - 14 N2 - BACKGROUND: The aim was to develop and validate the quality of life scale for nasopharyngeal carcinoma (NPC) patients, the QOL-NPC (version 2), a specific instrument to measure quality of life for NPC patients. METHODS: The QOL-NPC was developed and validated according to standard procedures. The patients were assessed using the QOL-NPC, FACT-G, and FACT-H&N. Classical test theory was used to evaluate the reliability, validity, and responsiveness of the QOL-NPC. RESULTS: A total of 487 patients (97.4 %) completed the questionnaire. The QOL-NPC comprised four domains, as follows: physical function (eight items); psychological function (five items); social function (five items); and side effects (eight items). All of the items had a lower proportion of missing data. Cronbach's alpha values of the domains ranged from 0.72 to 0.84. The split-half reliability coefficients ranged from 0.77 to 0.84. All of the intra-class correlation coefficients were > 0.8. The normed fit index, non-normed fit index, and comparative fit index were >0.89. The root mean square error of approximation was 0.097, with a 90 % confidence interval (0.093, 0.100). The domain scores of the QOL-NPC were significantly correlated with the FACT-G and FACT-H&N (P < 0.05). All of the domain scores of patients using different amounts of radiotherapy were significantly different (P < 0.001). All domain scores decreased at the completion of radiotherapy, with effect sizes ranging from -0.82 to -0.22. CONCLUSIONS: The QOL-NPC is valid for measuring QOL with good reliability, validity, and responsiveness. The QOL-NPC is recommended to measure the QOL for Chinese NPC patients. SN - 1477-7525 UR - https://www.unboundmedicine.com/medline/citation/27164979/Development_and_validation_of_quality_of_life_scale_of_nasopharyngeal_carcinoma_patients:_the_QOL_NPC__version_2__ L2 - https://hqlo.biomedcentral.com/articles/10.1186/s12955-016-0480-0 DB - PRIME DP - Unbound Medicine ER -