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Bioelectrical phase angle and psoriasis: a novel association with psoriasis severity, quality of life and metabolic syndrome.

Abstract

BACKGROUND

Obesity, metabolic syndrome (MetS), and psoriasis, largely driven by environmental factors, show multiple bidirectional associations, with important metabolic implications in psoriatic patients. Besides body mass index (BMI) as a measure of obesity, data on phase angle (PhA), a direct measure by bioelectrical impedance analysis (BIA), used as a marker of cellular health and a predictor of morbidity and mortality in various diseases, are still lacking in psoriasis. In this case-control, cross-sectional study, we investigated the PhA in 180 pairs of adult psoriatic patients and healthy controls, evaluating also the potential use of the PhA as marker of the clinical severity, the quality of life, and the presence of the MetS in psoriatic patients.

METHODS

Anthropometric measures, metabolic profile and bioelectrical variables were evaluated. The clinical severity was assessed by standardized psoriasis area and severity index (PASI) score and c-reactive protein (CRP) levels, and the quality of life was evaluated by dermatology life quality index (DLQI). MetS was diagnosed according to Adult Treatment Panel III.

RESULTS

Psoriatic patients presented smaller PhA (p < 0.001) and higher prevalence MetS compared with controls. The PhA was significantly associated with number of parameters of MetS in both groups (p < 0.001). After adjusting for BMI, this association remained significant in psoriatic patients only (p < 0.001). Among psoriatic patients, the PhA was the major index value for the diagnosis of MetS (OR 5.87, 95 % CI 5.07-6.79) and was inversely associated with both PASI score and DLQI, independently of BMI (p < 0.001). At multiple regression analysis, the PhA well predicted the PASI score and DLQI. Based on ROC curves, the most sensitive and specific cutoffs of PhA to predict the highest PASI score and the lowest DQLI were ≤4.8° and ≤4.9°, respectively.

CONCLUSIONS

We reported that psoriatic patients presented small PhAs, with a novel association between PhA, clinical severity, quality of life in psoriatic patients, and MetS. Further studies are required to validate the PhA's prognostic ability in assessing the clinical severity and MetS in psoriatic patients.

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  • Authors+Show Affiliations

    ,

    I.O.S. & COLEMAN Srl, Naples, Italy. luigi.barrea@unina.it.

    ,

    Dipartimento di Medicina Clinica e Chirurgia, Unit of Endocrinology, Federico II University Medical School of Naples, Via Sergio Pansini 5, 80131, Naples, Italy.

    ,

    IRCCS SDN, Napoli Via Gianturco 113, 80143, Naples, Italy.

    ,

    Dipartimento di Medicina Clinica e Chirurgia, Unit of Dermatology, Federico II University Medical School of Naples, Via Sergio Pansini 5, 80131, Naples, Italy.

    ,

    Dipartimento di Medicina Clinica e Chirurgia, Unit of Dermatology, Federico II University Medical School of Naples, Via Sergio Pansini 5, 80131, Naples, Italy.

    ,

    I.O.S. & COLEMAN Srl, Naples, Italy.

    ,

    I.O.S. & COLEMAN Srl, Naples, Italy.

    ,

    Dipartimento di Medicina Clinica e Chirurgia, Unit of Dermatology, Federico II University Medical School of Naples, Via Sergio Pansini 5, 80131, Naples, Italy.

    ,

    Dipartimento di Medicina Clinica e Chirurgia, Unit of Endocrinology, Federico II University Medical School of Naples, Via Sergio Pansini 5, 80131, Naples, Italy.

    Dipartimento di Medicina Clinica e Chirurgia, Unit of Endocrinology, Federico II University Medical School of Naples, Via Sergio Pansini 5, 80131, Naples, Italy.

    Source

    Journal of translational medicine 14:1 2016 05 10 pg 130

    MeSH

    Adult
    Aged
    Biomechanical Phenomena
    Case-Control Studies
    Electric Impedance
    Female
    Humans
    Male
    Metabolic Syndrome
    Middle Aged
    Odds Ratio
    Psoriasis
    Quality of Life
    Regression Analysis
    Risk Factors
    Severity of Illness Index
    Young Adult

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    27165166

    Citation

    Barrea, Luigi, et al. "Bioelectrical Phase Angle and Psoriasis: a Novel Association With Psoriasis Severity, Quality of Life and Metabolic Syndrome." Journal of Translational Medicine, vol. 14, no. 1, 2016, p. 130.
    Barrea L, Macchia PE, Di Somma C, et al. Bioelectrical phase angle and psoriasis: a novel association with psoriasis severity, quality of life and metabolic syndrome. J Transl Med. 2016;14(1):130.
    Barrea, L., Macchia, P. E., Di Somma, C., Napolitano, M., Balato, A., Falco, A., ... Savastano, S. (2016). Bioelectrical phase angle and psoriasis: a novel association with psoriasis severity, quality of life and metabolic syndrome. Journal of Translational Medicine, 14(1), p. 130. doi:10.1186/s12967-016-0889-6.
    Barrea L, et al. Bioelectrical Phase Angle and Psoriasis: a Novel Association With Psoriasis Severity, Quality of Life and Metabolic Syndrome. J Transl Med. 2016 05 10;14(1):130. PubMed PMID: 27165166.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Bioelectrical phase angle and psoriasis: a novel association with psoriasis severity, quality of life and metabolic syndrome. AU - Barrea,Luigi, AU - Macchia,Paolo Emidio, AU - Di Somma,Carolina, AU - Napolitano,Maddalena, AU - Balato,Anna, AU - Falco,Andrea, AU - Savanelli,Maria Cristina, AU - Balato,Nicola, AU - Colao,Annamaria, AU - Savastano,Silvia, Y1 - 2016/05/10/ PY - 2015/12/24/received PY - 2016/04/29/accepted PY - 2016/5/12/entrez PY - 2016/5/12/pubmed PY - 2017/10/17/medline KW - Dermatology life quality index (DLQI) KW - Environmental factors KW - Metabolic syndrome (MetS) KW - Phase angle (PhA) KW - Psoriasis area and severity index (PASI) score SP - 130 EP - 130 JF - Journal of translational medicine JO - J Transl Med VL - 14 IS - 1 N2 - BACKGROUND: Obesity, metabolic syndrome (MetS), and psoriasis, largely driven by environmental factors, show multiple bidirectional associations, with important metabolic implications in psoriatic patients. Besides body mass index (BMI) as a measure of obesity, data on phase angle (PhA), a direct measure by bioelectrical impedance analysis (BIA), used as a marker of cellular health and a predictor of morbidity and mortality in various diseases, are still lacking in psoriasis. In this case-control, cross-sectional study, we investigated the PhA in 180 pairs of adult psoriatic patients and healthy controls, evaluating also the potential use of the PhA as marker of the clinical severity, the quality of life, and the presence of the MetS in psoriatic patients. METHODS: Anthropometric measures, metabolic profile and bioelectrical variables were evaluated. The clinical severity was assessed by standardized psoriasis area and severity index (PASI) score and c-reactive protein (CRP) levels, and the quality of life was evaluated by dermatology life quality index (DLQI). MetS was diagnosed according to Adult Treatment Panel III. RESULTS: Psoriatic patients presented smaller PhA (p < 0.001) and higher prevalence MetS compared with controls. The PhA was significantly associated with number of parameters of MetS in both groups (p < 0.001). After adjusting for BMI, this association remained significant in psoriatic patients only (p < 0.001). Among psoriatic patients, the PhA was the major index value for the diagnosis of MetS (OR 5.87, 95 % CI 5.07-6.79) and was inversely associated with both PASI score and DLQI, independently of BMI (p < 0.001). At multiple regression analysis, the PhA well predicted the PASI score and DLQI. Based on ROC curves, the most sensitive and specific cutoffs of PhA to predict the highest PASI score and the lowest DQLI were ≤4.8° and ≤4.9°, respectively. CONCLUSIONS: We reported that psoriatic patients presented small PhAs, with a novel association between PhA, clinical severity, quality of life in psoriatic patients, and MetS. Further studies are required to validate the PhA's prognostic ability in assessing the clinical severity and MetS in psoriatic patients. SN - 1479-5876 UR - https://www.unboundmedicine.com/medline/citation/27165166/Bioelectrical_phase_angle_and_psoriasis:_a_novel_association_with_psoriasis_severity_quality_of_life_and_metabolic_syndrome_ L2 - https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-016-0889-6 DB - PRIME DP - Unbound Medicine ER -