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Poly(3,4-ethylenedioxythiophene):GlycosAminoGlycan Aqueous Dispersions: Toward Electrically Conductive Bioactive Materials for Neural Interfaces.
Macromol Biosci. 2016 08; 16(8):1227-38.MB

Abstract

There is an actual need of advanced materials for the emerging field of bioelectronics. One commonly used material is the conducting polymer poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (

PEDOT

PSS) due to its general use in organic electronics. However, depending on the application in bioelectronics,

PEDOT

PSS is not fully biocompatible due to the high acidity of the residual sulfonate protons of PSS. In this paper, the synthesis and biocompatibility properties of new poly(3,4-ethylenedioxythiophene):GlycosAminoGlycan (

PEDOT

GAG) aqueous dispersions and its resulting films are shown. Thus, negatively charged GAGs as an alternative to PSS are presented. Three different commercially available GAGs, hyaluronic acid, heparin, and chondroitin sulfate are used. Indeed,

PEDOT

GAGs dispersions are prepared through an oxidative chemical polymerization in water. Biocompatibility assays of the

PEDOT

GAGs coatings are performed using SH-SY5Y and CCF-STTG1 cell lines and with ATP and Ca(2+) . Results show full biocompatibility and a pronounced anti-inflammatory effect. This last characteristic becomes crucial if implanted in the body. These materials can be used for in vivo applications, as transistor or electrode for electrical recording and for all the possible situations when there is contact between electronic circuits and living tissues.

Authors+Show Affiliations

Institute for Polymer Materials (POLYMAT), University of the Basque Country UPV/EHU, Joxe Mari Korta Center, Avda. Tolosa 72, 20018, Donostia-san, Sebastian, Spain.Institute for Polymer Materials (POLYMAT), University of the Basque Country UPV/EHU, Joxe Mari Korta Center, Avda. Tolosa 72, 20018, Donostia-san, Sebastian, Spain.Histocell, S.L, Science and Technology Park, 48170 Derio, Vizcaya, Spain.Histocell, S.L, Science and Technology Park, 48170 Derio, Vizcaya, Spain.Histocell, S.L, Science and Technology Park, 48170 Derio, Vizcaya, Spain.Institute for Polymer Materials (POLYMAT), University of the Basque Country UPV/EHU, Joxe Mari Korta Center, Avda. Tolosa 72, 20018, Donostia-san, Sebastian, Spain.Institute for Polymer Materials (POLYMAT), University of the Basque Country UPV/EHU, Joxe Mari Korta Center, Avda. Tolosa 72, 20018, Donostia-san, Sebastian, Spain. Ikerbasque, Basque Foundation for Science, E-48011, Bilbao, Spain.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27168277

Citation

Mantione, Daniele, et al. "Poly(3,4-ethylenedioxythiophene):GlycosAminoGlycan Aqueous Dispersions: Toward Electrically Conductive Bioactive Materials for Neural Interfaces." Macromolecular Bioscience, vol. 16, no. 8, 2016, pp. 1227-38.
Mantione D, Del Agua I, Schaafsma W, et al. Poly(3,4-ethylenedioxythiophene):GlycosAminoGlycan Aqueous Dispersions: Toward Electrically Conductive Bioactive Materials for Neural Interfaces. Macromol Biosci. 2016;16(8):1227-38.
Mantione, D., Del Agua, I., Schaafsma, W., Diez-Garcia, J., Castro, B., Sardon, H., & Mecerreyes, D. (2016). Poly(3,4-ethylenedioxythiophene):GlycosAminoGlycan Aqueous Dispersions: Toward Electrically Conductive Bioactive Materials for Neural Interfaces. Macromolecular Bioscience, 16(8), 1227-38. https://doi.org/10.1002/mabi.201600059
Mantione D, et al. Poly(3,4-ethylenedioxythiophene):GlycosAminoGlycan Aqueous Dispersions: Toward Electrically Conductive Bioactive Materials for Neural Interfaces. Macromol Biosci. 2016;16(8):1227-38. PubMed PMID: 27168277.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Poly(3,4-ethylenedioxythiophene):GlycosAminoGlycan Aqueous Dispersions: Toward Electrically Conductive Bioactive Materials for Neural Interfaces. AU - Mantione,Daniele, AU - Del Agua,Isabel, AU - Schaafsma,Wandert, AU - Diez-Garcia,Javier, AU - Castro,Begona, AU - Sardon,Haritz, AU - Mecerreyes,David, Y1 - 2016/05/11/ PY - 2016/02/17/received PY - 2016/04/07/revised PY - 2016/5/12/entrez PY - 2016/5/12/pubmed PY - 2017/10/24/medline KW - GAGs KW - PEDOT KW - biocompatible KW - conductive polymers KW - neuroprotective SP - 1227 EP - 38 JF - Macromolecular bioscience JO - Macromol Biosci VL - 16 IS - 8 N2 - UNLABELLED: There is an actual need of advanced materials for the emerging field of bioelectronics. One commonly used material is the conducting polymer poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) ( PEDOT: PSS) due to its general use in organic electronics. However, depending on the application in bioelectronics, PEDOT: PSS is not fully biocompatible due to the high acidity of the residual sulfonate protons of PSS. In this paper, the synthesis and biocompatibility properties of new poly(3,4-ethylenedioxythiophene):GlycosAminoGlycan ( PEDOT: GAG) aqueous dispersions and its resulting films are shown. Thus, negatively charged GAGs as an alternative to PSS are presented. Three different commercially available GAGs, hyaluronic acid, heparin, and chondroitin sulfate are used. Indeed, PEDOT: GAGs dispersions are prepared through an oxidative chemical polymerization in water. Biocompatibility assays of the PEDOT: GAGs coatings are performed using SH-SY5Y and CCF-STTG1 cell lines and with ATP and Ca(2+) . Results show full biocompatibility and a pronounced anti-inflammatory effect. This last characteristic becomes crucial if implanted in the body. These materials can be used for in vivo applications, as transistor or electrode for electrical recording and for all the possible situations when there is contact between electronic circuits and living tissues. SN - 1616-5195 UR - https://www.unboundmedicine.com/medline/citation/27168277/Poly_34_ethylenedioxythiophene_:GlycosAminoGlycan_Aqueous_Dispersions:_Toward_Electrically_Conductive_Bioactive_Materials_for_Neural_Interfaces_ L2 - https://doi.org/10.1002/mabi.201600059 DB - PRIME DP - Unbound Medicine ER -