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Coordinated brain development: exploring the synchrony between changes in grey and white matter during childhood maturation.
Brain Imaging Behav 2017; 11(3):808-817BI

Abstract

Brain development during childhood and early adolescence is characterized by global changes in brain architecture. Neuroimaging studies have revealed overall decreases in cortical thickness (CT) and increases in fractional anisotropy (FA). Furthermore, previous studies have shown that certain cortical regions display coordinated growth during development. However, there is significant heterogeneity in the timing and speed of these developmental transformations, and it is still unclear whether white and grey matter changes are co-localized. In this multimodal neuroimaging study, we investigated the relationship between grey and white matter developmental changes and asynchronous maturation within brain regions in 249 normally developing children between the ages 7-14. We used structural magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) to analyze CT and FA, respectively, as well as their covariance across development. Consistent with previous studies, we observed overall cortical thinning with age, which was accompanied by increased FA. We then compared the coordinated development of grey and white matter as indexed by covariance measures. Covariance between grey matter regions and the microstructure of white matter tracts connecting those regions were highly similar, suggesting that coordinated changes in the cortex were mirrored by coordinated changes in their respective tracts. Examining within-brain divergent trajectories, we found significant structural decoupling (decreased covariance) between several brain regions and tracts in the 9- to 11-year-old group, particularly involving the forceps minor and the regions that it connects to. We argue that this decoupling could reflect a developmental pattern within the prefrontal region in 9- and 11-year-old children, possibly related to the significant changes in cognitive control observed at this age.

Authors+Show Affiliations

Department of Psychiatry, Federal University of Sao Paulo, Rua Borges Lagoa, 570 1°Andar, CEP, São Paulo, 04039-032, Brazil. lummoura@gmail.com. Interdisciplinary Lab of Clinical Neurosciences (LiNC), Federal University of Sao Paulo (UNIFESP), Sao Paulo, Brazil. lummoura@gmail.com. Institute of Psychiatry, Psychology and Neurosciences, King's College London, London, UK. lummoura@gmail.com.Institute of Psychiatry, Psychology and Neurosciences, King's College London, London, UK. Biological and Medical Engineering Institute and Department of Psychiatry, P. Catholic University of Chile, Santiago, Chile.Department of Psychiatry, Federal University of Sao Paulo, Rua Borges Lagoa, 570 1°Andar, CEP, São Paulo, 04039-032, Brazil. Interdisciplinary Lab of Clinical Neurosciences (LiNC), Federal University of Sao Paulo (UNIFESP), Sao Paulo, Brazil. Institute of Psychiatry, Psychology and Neurosciences, King's College London, London, UK.Department of Psychiatry, Federal University of Sao Paulo, Rua Borges Lagoa, 570 1°Andar, CEP, São Paulo, 04039-032, Brazil. Interdisciplinary Lab of Clinical Neurosciences (LiNC), Federal University of Sao Paulo (UNIFESP), Sao Paulo, Brazil.Department of Psychiatry, Federal University of Sao Paulo, Rua Borges Lagoa, 570 1°Andar, CEP, São Paulo, 04039-032, Brazil. Interdisciplinary Lab of Clinical Neurosciences (LiNC), Federal University of Sao Paulo (UNIFESP), Sao Paulo, Brazil.Department of Psychiatry, Federal University of Sao Paulo, Rua Borges Lagoa, 570 1°Andar, CEP, São Paulo, 04039-032, Brazil. Interdisciplinary Lab of Clinical Neurosciences (LiNC), Federal University of Sao Paulo (UNIFESP), Sao Paulo, Brazil.National Institute of Developmental Psychiatry for Children and Adolescents, National Counsel of Technological and Scientific Development (CNPq), São Paulo, Brazil.National Institute of Developmental Psychiatry for Children and Adolescents, National Counsel of Technological and Scientific Development (CNPq), São Paulo, Brazil.Radiology Department, Sao Paulo Medical School, University of Sao Paulo, Sao Paulo, Brazil.Department of Psychiatry, Federal University of Sao Paulo, Rua Borges Lagoa, 570 1°Andar, CEP, São Paulo, 04039-032, Brazil.Department of Psychiatry, Sao Paulo Medical School, University of Sao Paulo, Sao Paulo, Brazil.National Institute of Developmental Psychiatry for Children and Adolescents, National Counsel of Technological and Scientific Development (CNPq), São Paulo, Brazil. Department of Psychiatry, Federal University of Rio Grande do Sul, Rio Grande do Sul, Brazil.Department of Psychiatry, Federal University of Sao Paulo, Rua Borges Lagoa, 570 1°Andar, CEP, São Paulo, 04039-032, Brazil. Interdisciplinary Lab of Clinical Neurosciences (LiNC), Federal University of Sao Paulo (UNIFESP), Sao Paulo, Brazil.Institute of Psychiatry, Psychology and Neurosciences, King's College London, London, UK.Center of Mathematics, Computation and Cognition, Universidade Federal do ABC, Santo Andre, Brazil.Department of Psychiatry, Federal University of Sao Paulo, Rua Borges Lagoa, 570 1°Andar, CEP, São Paulo, 04039-032, Brazil. Interdisciplinary Lab of Clinical Neurosciences (LiNC), Federal University of Sao Paulo (UNIFESP), Sao Paulo, Brazil.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27169540

Citation

Moura, L M., et al. "Coordinated Brain Development: Exploring the Synchrony Between Changes in Grey and White Matter During Childhood Maturation." Brain Imaging and Behavior, vol. 11, no. 3, 2017, pp. 808-817.
Moura LM, Crossley NA, Zugman A, et al. Coordinated brain development: exploring the synchrony between changes in grey and white matter during childhood maturation. Brain Imaging Behav. 2017;11(3):808-817.
Moura, L. M., Crossley, N. A., Zugman, A., Pan, P. M., Gadelha, A., Del Aquilla, M. A. G., ... Jackowski, A. P. (2017). Coordinated brain development: exploring the synchrony between changes in grey and white matter during childhood maturation. Brain Imaging and Behavior, 11(3), pp. 808-817. doi:10.1007/s11682-016-9555-0.
Moura LM, et al. Coordinated Brain Development: Exploring the Synchrony Between Changes in Grey and White Matter During Childhood Maturation. Brain Imaging Behav. 2017;11(3):808-817. PubMed PMID: 27169540.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coordinated brain development: exploring the synchrony between changes in grey and white matter during childhood maturation. AU - Moura,L M, AU - Crossley,N A, AU - Zugman,A, AU - Pan,P M, AU - Gadelha,A, AU - Del Aquilla,M A G, AU - Picon,F A, AU - Anés,M, AU - Amaro,E,Jr AU - de Jesus Mari,J, AU - Miguel,E C, AU - Rohde,L A, AU - Bressan,R A, AU - McGuire,P, AU - Sato,J R, AU - Jackowski,A P, PY - 2016/5/14/pubmed PY - 2018/3/28/medline PY - 2016/5/13/entrez KW - Children KW - Connectivity KW - Frontopolar cortex KW - Neurodevelopment KW - Structural covariance SP - 808 EP - 817 JF - Brain imaging and behavior JO - Brain Imaging Behav VL - 11 IS - 3 N2 - Brain development during childhood and early adolescence is characterized by global changes in brain architecture. Neuroimaging studies have revealed overall decreases in cortical thickness (CT) and increases in fractional anisotropy (FA). Furthermore, previous studies have shown that certain cortical regions display coordinated growth during development. However, there is significant heterogeneity in the timing and speed of these developmental transformations, and it is still unclear whether white and grey matter changes are co-localized. In this multimodal neuroimaging study, we investigated the relationship between grey and white matter developmental changes and asynchronous maturation within brain regions in 249 normally developing children between the ages 7-14. We used structural magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) to analyze CT and FA, respectively, as well as their covariance across development. Consistent with previous studies, we observed overall cortical thinning with age, which was accompanied by increased FA. We then compared the coordinated development of grey and white matter as indexed by covariance measures. Covariance between grey matter regions and the microstructure of white matter tracts connecting those regions were highly similar, suggesting that coordinated changes in the cortex were mirrored by coordinated changes in their respective tracts. Examining within-brain divergent trajectories, we found significant structural decoupling (decreased covariance) between several brain regions and tracts in the 9- to 11-year-old group, particularly involving the forceps minor and the regions that it connects to. We argue that this decoupling could reflect a developmental pattern within the prefrontal region in 9- and 11-year-old children, possibly related to the significant changes in cognitive control observed at this age. SN - 1931-7565 UR - https://www.unboundmedicine.com/medline/citation/27169540/Coordinated_brain_development:_exploring_the_synchrony_between_changes_in_grey_and_white_matter_during_childhood_maturation_ L2 - https://dx.doi.org/10.1007/s11682-016-9555-0 DB - PRIME DP - Unbound Medicine ER -