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Prospective Study of Alcohol Drinking, Smoking, and Pancreatitis: The Multiethnic Cohort.
Pancreas 2016; 45(6):819-25P

Abstract

OBJECTIVES

We conducted a prospective analysis of 145,886 participants in the multiethnic cohort to examine the relationship of alcohol drinking and smoking with pancreatitis.

METHODS

Pancreatitis cases were categorized as gallstone-related acute pancreatitis (GSAP) (N = 1,065), non-GSAP (N = 1,222), and recurrent acute (RAP)/chronic pancreatitis (CP) (N = 523). We used the baseline questionnaire to identify alcohol intake and smoking history. Associations were estimated by hazard ratios (HRs) and 95% confidence intervals (CIs) using Cox models.

RESULTS

Cigarette smoking was associated with non-GSAP and RAP/CP. Moderate alcohol intake was inversely associated with all types of pancreatitis in women (HRs, 0.66 to 0.81 for <1 drink per day), and with RAP/CP in men (HR, 0.57; 95% CI, 0.41-0.79 for <2 drinks per day). The risk of non-GS pancreatitis associated with current smoking was highest among men who consumed more than 4 drinks per day (HR, 2.06; 95% CI, 1.28-3.30), whereas among never smokers, moderate drinking was associated with a reduced risk (HR, 0.70; 95% CI, 0.51-0.96). In women, drinking less than 2 drinks per day was associated with a reduced risk of GSAP among never smokers (HR, 0.61; 95% CI, 0.46-0.80).

CONCLUSIONS

Smoking is a risk factor for non-GS pancreatitis. Moderate alcohol intake is protective against all types of pancreatitis in women and against RAP/CP in men.

Authors+Show Affiliations

From the *Department of Preventive Medicine, and †Norris Comprehensive Cancer Center, Keck School of Medicine of University of Southern California, Los Angeles, CA; ‡Division of Gastroenterology, Department of Medicine, Cedars-Sinai Medical Center and Department of Veterans Affairs, Los Angeles, CA; §Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI; ∥Memorial Sloan Kettering Cancer Center, New York, NY.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

27171516

Citation

Setiawan, Veronica Wendy, et al. "Prospective Study of Alcohol Drinking, Smoking, and Pancreatitis: the Multiethnic Cohort." Pancreas, vol. 45, no. 6, 2016, pp. 819-25.
Setiawan VW, Pandol SJ, Porcel J, et al. Prospective Study of Alcohol Drinking, Smoking, and Pancreatitis: The Multiethnic Cohort. Pancreas. 2016;45(6):819-25.
Setiawan, V. W., Pandol, S. J., Porcel, J., Wilkens, L. R., Le Marchand, L., Pike, M. C., & Monroe, K. R. (2016). Prospective Study of Alcohol Drinking, Smoking, and Pancreatitis: The Multiethnic Cohort. Pancreas, 45(6), pp. 819-25. doi:10.1097/MPA.0000000000000657.
Setiawan VW, et al. Prospective Study of Alcohol Drinking, Smoking, and Pancreatitis: the Multiethnic Cohort. Pancreas. 2016;45(6):819-25. PubMed PMID: 27171516.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prospective Study of Alcohol Drinking, Smoking, and Pancreatitis: The Multiethnic Cohort. AU - Setiawan,Veronica Wendy, AU - Pandol,Stephen J, AU - Porcel,Jacqueline, AU - Wilkens,Lynne R, AU - Le Marchand,Loïc, AU - Pike,Malcolm C, AU - Monroe,Kristine R, PY - 2016/5/13/entrez PY - 2016/5/14/pubmed PY - 2017/3/30/medline SP - 819 EP - 25 JF - Pancreas JO - Pancreas VL - 45 IS - 6 N2 - OBJECTIVES: We conducted a prospective analysis of 145,886 participants in the multiethnic cohort to examine the relationship of alcohol drinking and smoking with pancreatitis. METHODS: Pancreatitis cases were categorized as gallstone-related acute pancreatitis (GSAP) (N = 1,065), non-GSAP (N = 1,222), and recurrent acute (RAP)/chronic pancreatitis (CP) (N = 523). We used the baseline questionnaire to identify alcohol intake and smoking history. Associations were estimated by hazard ratios (HRs) and 95% confidence intervals (CIs) using Cox models. RESULTS: Cigarette smoking was associated with non-GSAP and RAP/CP. Moderate alcohol intake was inversely associated with all types of pancreatitis in women (HRs, 0.66 to 0.81 for <1 drink per day), and with RAP/CP in men (HR, 0.57; 95% CI, 0.41-0.79 for <2 drinks per day). The risk of non-GS pancreatitis associated with current smoking was highest among men who consumed more than 4 drinks per day (HR, 2.06; 95% CI, 1.28-3.30), whereas among never smokers, moderate drinking was associated with a reduced risk (HR, 0.70; 95% CI, 0.51-0.96). In women, drinking less than 2 drinks per day was associated with a reduced risk of GSAP among never smokers (HR, 0.61; 95% CI, 0.46-0.80). CONCLUSIONS: Smoking is a risk factor for non-GS pancreatitis. Moderate alcohol intake is protective against all types of pancreatitis in women and against RAP/CP in men. SN - 1536-4828 UR - https://www.unboundmedicine.com/medline/citation/27171516/Prospective_Study_of_Alcohol_Drinking_Smoking_and_Pancreatitis:_The_Multiethnic_Cohort_ L2 - http://Insights.ovid.com/pubmed?pmid=27171516 DB - PRIME DP - Unbound Medicine ER -