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The prostaglandin outflow from perfused mesenteric vasculature of rats fed different fats.

Abstract

The effects of dietary n-6 polyunsaturated fatty acids and replacement with saturated fat or fish oil on the prostaglandin outflow from perfused mesenteric vasculature in rats were studied. Seventy-two weanling male rats were fed ad libitum a semi-synthetic diet supplemented with 10% by weight of oil, composed wholly of n-6 fatty acid-rich evening primrose oil, or replaced partly or completely (25, 50, 75 or 100%) by n-6 fatty acid-deficient fish oil or hydrogenated coconut oil for 8 weeks. The outflows of 6-keto-PGF1 alpha, thromboxane B2, and prostaglandin E from the perfused mesenteric vasculature were measured at 60 min-time point after starting the perfusion. In general, the release of prostanoids from the mesenteric vasculature was significantly reduced in rats fed a diet in which evening primrose oil was partly or completely replaced by either hydrogenated coconut or fish oil. This was probably due to the insufficient conversion of linoleic acid to arachidonic acid. The extent of reduction was greater in fish oil-fed than in hydrogenated coconut oil-fed rats, while the levels of arachidonic acid in aortic phospholipids were similar between these two groups. This result implies that the greater reduction of prostaglandin synthesis in rats fed fish oil was due to the inhibitory effect of eicosapentaenoic and docosahexaenoic acids in fish oil on the conversion of arachidonate to eicosanoids.

Authors+Show Affiliations

Efamol Research Institute, Kentville, Nova Scotia, Canada.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2717652

Citation

Huang, Y S., et al. "The Prostaglandin Outflow From Perfused Mesenteric Vasculature of Rats Fed Different Fats." Prostaglandins, Leukotrienes, and Essential Fatty Acids, vol. 35, no. 2, 1989, pp. 73-9.
Huang YS, Nassar BA, Horrobin DF. The prostaglandin outflow from perfused mesenteric vasculature of rats fed different fats. Prostaglandins Leukot Essent Fatty Acids. 1989;35(2):73-9.
Huang, Y. S., Nassar, B. A., & Horrobin, D. F. (1989). The prostaglandin outflow from perfused mesenteric vasculature of rats fed different fats. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 35(2), 73-9.
Huang YS, Nassar BA, Horrobin DF. The Prostaglandin Outflow From Perfused Mesenteric Vasculature of Rats Fed Different Fats. Prostaglandins Leukot Essent Fatty Acids. 1989;35(2):73-9. PubMed PMID: 2717652.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The prostaglandin outflow from perfused mesenteric vasculature of rats fed different fats. AU - Huang,Y S, AU - Nassar,B A, AU - Horrobin,D F, PY - 1989/2/1/pubmed PY - 1989/2/1/medline PY - 1989/2/1/entrez SP - 73 EP - 9 JF - Prostaglandins, leukotrienes, and essential fatty acids JO - Prostaglandins Leukot Essent Fatty Acids VL - 35 IS - 2 N2 - The effects of dietary n-6 polyunsaturated fatty acids and replacement with saturated fat or fish oil on the prostaglandin outflow from perfused mesenteric vasculature in rats were studied. Seventy-two weanling male rats were fed ad libitum a semi-synthetic diet supplemented with 10% by weight of oil, composed wholly of n-6 fatty acid-rich evening primrose oil, or replaced partly or completely (25, 50, 75 or 100%) by n-6 fatty acid-deficient fish oil or hydrogenated coconut oil for 8 weeks. The outflows of 6-keto-PGF1 alpha, thromboxane B2, and prostaglandin E from the perfused mesenteric vasculature were measured at 60 min-time point after starting the perfusion. In general, the release of prostanoids from the mesenteric vasculature was significantly reduced in rats fed a diet in which evening primrose oil was partly or completely replaced by either hydrogenated coconut or fish oil. This was probably due to the insufficient conversion of linoleic acid to arachidonic acid. The extent of reduction was greater in fish oil-fed than in hydrogenated coconut oil-fed rats, while the levels of arachidonic acid in aortic phospholipids were similar between these two groups. This result implies that the greater reduction of prostaglandin synthesis in rats fed fish oil was due to the inhibitory effect of eicosapentaenoic and docosahexaenoic acids in fish oil on the conversion of arachidonate to eicosanoids. SN - 0952-3278 UR - https://www.unboundmedicine.com/medline/citation/2717652/The_prostaglandin_outflow_from_perfused_mesenteric_vasculature_of_rats_fed_different_fats_ DB - PRIME DP - Unbound Medicine ER -