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A Novel Collagen-Gelatin Scaffold for the Treatment of Deep Dermal Wounds-An Evaluation in a Minipig Model.
Dermatol Surg. 2016 Jun; 42(6):751-6.DS

Abstract

BACKGROUND

Today, autologous skin transplantation is frequently used for full-thickness skin defects. There is still a high demand for new wound-healing products to replace autologous skin transplantation.

OBJECTIVE

In this context, the effect of a new collagen-gelatin scaffold on full-thickness skin defects was evaluated.

MATERIALS AND METHODS

Four full-thickness skin defects were created surgically on the dorsum of 6 Göttingen minipigs. Three wounds were randomly treated with a novel collagen-gelatin scaffold in different thicknesses, whereas the fourth wound was left untreated and served as a control wound. During the experimental period of 21 days, a close-up photographic documentation was performed. Afterwards, the areas of the initial wounds were excised and examined histologically.

RESULTS

The systematic evaluation of 24 wounds showed that treatment with the new collagen-gelatin scaffold led to an accelerated wound repair of 1.1 days. Compared to control wounds, it also demonstrated improved skin quality in regard to epidermal thickness.

CONCLUSION

The new collagen-gelatin scaffold supports and accelerates dermal wound repair compared to untreated control wounds. Nevertheless, wound treatment with the scaffold was only performed on the first day. In further studies, the impact of multiple scaffold applications on full-thickness skin defects should be investigated.

Authors+Show Affiliations

*Department of Plastic, Reconstructive, Hand and Burn Surgery, BG-Trauma Center, Eberhard Karls University Tuebingen, Germany; †Department of Plastic and Hand Surgery, Reconstructive and Aesthetic Surgery, HELIOS Klinikum Wuppertal GmbH, University Hospital Witten/Herdecke, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27176867

Citation

Held, Manuel, et al. "A Novel Collagen-Gelatin Scaffold for the Treatment of Deep Dermal Wounds-An Evaluation in a Minipig Model." Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.], vol. 42, no. 6, 2016, pp. 751-6.
Held M, Rahmanian-Schwarz A, Schiefer J, et al. A Novel Collagen-Gelatin Scaffold for the Treatment of Deep Dermal Wounds-An Evaluation in a Minipig Model. Dermatol Surg. 2016;42(6):751-6.
Held, M., Rahmanian-Schwarz, A., Schiefer, J., Rath, R., Werner, J. O., Rahmanian, S., Schaller, H. E., & Petersen, W. (2016). A Novel Collagen-Gelatin Scaffold for the Treatment of Deep Dermal Wounds-An Evaluation in a Minipig Model. Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.], 42(6), 751-6. https://doi.org/10.1097/DSS.0000000000000727
Held M, et al. A Novel Collagen-Gelatin Scaffold for the Treatment of Deep Dermal Wounds-An Evaluation in a Minipig Model. Dermatol Surg. 2016;42(6):751-6. PubMed PMID: 27176867.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A Novel Collagen-Gelatin Scaffold for the Treatment of Deep Dermal Wounds-An Evaluation in a Minipig Model. AU - Held,Manuel, AU - Rahmanian-Schwarz,Afshin, AU - Schiefer,Jennifer, AU - Rath,Rebekka, AU - Werner,Jan-Ole, AU - Rahmanian,Shahab, AU - Schaller,Hans-Eberhard, AU - Petersen,Wiebke, PY - 2016/5/14/entrez PY - 2016/5/14/pubmed PY - 2017/4/4/medline SP - 751 EP - 6 JF - Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] JO - Dermatol Surg VL - 42 IS - 6 N2 - BACKGROUND: Today, autologous skin transplantation is frequently used for full-thickness skin defects. There is still a high demand for new wound-healing products to replace autologous skin transplantation. OBJECTIVE: In this context, the effect of a new collagen-gelatin scaffold on full-thickness skin defects was evaluated. MATERIALS AND METHODS: Four full-thickness skin defects were created surgically on the dorsum of 6 Göttingen minipigs. Three wounds were randomly treated with a novel collagen-gelatin scaffold in different thicknesses, whereas the fourth wound was left untreated and served as a control wound. During the experimental period of 21 days, a close-up photographic documentation was performed. Afterwards, the areas of the initial wounds were excised and examined histologically. RESULTS: The systematic evaluation of 24 wounds showed that treatment with the new collagen-gelatin scaffold led to an accelerated wound repair of 1.1 days. Compared to control wounds, it also demonstrated improved skin quality in regard to epidermal thickness. CONCLUSION: The new collagen-gelatin scaffold supports and accelerates dermal wound repair compared to untreated control wounds. Nevertheless, wound treatment with the scaffold was only performed on the first day. In further studies, the impact of multiple scaffold applications on full-thickness skin defects should be investigated. SN - 1524-4725 UR - https://www.unboundmedicine.com/medline/citation/27176867/A_Novel_Collagen_Gelatin_Scaffold_for_the_Treatment_of_Deep_Dermal_Wounds_An_Evaluation_in_a_Minipig_Model_ L2 - http://Insights.ovid.com/pubmed?pmid=27176867 DB - PRIME DP - Unbound Medicine ER -