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Clivus height value: a new diagnostic method for basilar invagination at CT.
Clin Radiol. 2016 Nov; 71(11):1200.e1-5.CR

Abstract

AIM

To investigate whether clivus height (CH; the distance of the basion above Chamberlain's line) could be used to diagnose basilar invagination (BI) at computed tomography (CT).

MATERIALS AND METHODS

This retrospective study received institutional review board approval, and was performed from 1 January 2013, to 1 July 2015 with a waiver of informed consent. CH was measured on mid-sagittal reconstructed CT images from 65 BI patients and 85 control subjects to compare the two groups by using the independent-samples t-test. Inter- and intra-observer reliability were evaluated with the intraclass correlation coefficient (ICC). To evaluate the diagnostic performance and determine the cut-off value of CH, receiver operating characteristic (ROC) curves were utilised.

RESULTS

The measurement of CH showed good inter- and intra-observer agreement (ICC=0.96 and 0.98, respectively). Compared with control subjects whose mean CH value was 0.35±0.29 cm (range, -0.18 to 1.2 cm), BI patients had a significantly (p<0.001) larger CH, 1.2±0.55 cm (range, 0.43-3.2 cm). The area under the ROC curve was 0.949 (95% confidence interval: 0.916, 0.982), and based on the cut-off value of 0.65 cm, the sensitivity, specificity, positive predictive value, and negative predictive value were 0.88 (57/65), 0.88 (75/85), 0.85 (57/67), and 0.91 (75/82), respectively.

CONCLUSION

Although not better than CL (the distance of the odontoid tip above Chamberlain's line), measurement of CH at CT is reproducible and can diagnose patients with BI.

Authors+Show Affiliations

Shandong Medical Imaging Research Institute, Shandong University, Jinan, China.Shandong Medical Imaging Research Institute, Shandong University, Jinan, China. Electronic address: grzh99@126.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27177855

Citation

Xu, S, and R Gong. "Clivus Height Value: a New Diagnostic Method for Basilar Invagination at CT." Clinical Radiology, vol. 71, no. 11, 2016, pp. 1200.e1-5.
Xu S, Gong R. Clivus height value: a new diagnostic method for basilar invagination at CT. Clin Radiol. 2016;71(11):1200.e1-5.
Xu, S., & Gong, R. (2016). Clivus height value: a new diagnostic method for basilar invagination at CT. Clinical Radiology, 71(11), e1-5. https://doi.org/10.1016/j.crad.2016.04.007
Xu S, Gong R. Clivus Height Value: a New Diagnostic Method for Basilar Invagination at CT. Clin Radiol. 2016;71(11):1200.e1-5. PubMed PMID: 27177855.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clivus height value: a new diagnostic method for basilar invagination at CT. AU - Xu,S, AU - Gong,R, Y1 - 2016/05/10/ PY - 2015/11/19/received PY - 2016/03/22/revised PY - 2016/04/05/accepted PY - 2016/5/15/entrez PY - 2016/5/15/pubmed PY - 2017/3/4/medline SP - 1200.e1 EP - 5 JF - Clinical radiology JO - Clin Radiol VL - 71 IS - 11 N2 - AIM: To investigate whether clivus height (CH; the distance of the basion above Chamberlain's line) could be used to diagnose basilar invagination (BI) at computed tomography (CT). MATERIALS AND METHODS: This retrospective study received institutional review board approval, and was performed from 1 January 2013, to 1 July 2015 with a waiver of informed consent. CH was measured on mid-sagittal reconstructed CT images from 65 BI patients and 85 control subjects to compare the two groups by using the independent-samples t-test. Inter- and intra-observer reliability were evaluated with the intraclass correlation coefficient (ICC). To evaluate the diagnostic performance and determine the cut-off value of CH, receiver operating characteristic (ROC) curves were utilised. RESULTS: The measurement of CH showed good inter- and intra-observer agreement (ICC=0.96 and 0.98, respectively). Compared with control subjects whose mean CH value was 0.35±0.29 cm (range, -0.18 to 1.2 cm), BI patients had a significantly (p<0.001) larger CH, 1.2±0.55 cm (range, 0.43-3.2 cm). The area under the ROC curve was 0.949 (95% confidence interval: 0.916, 0.982), and based on the cut-off value of 0.65 cm, the sensitivity, specificity, positive predictive value, and negative predictive value were 0.88 (57/65), 0.88 (75/85), 0.85 (57/67), and 0.91 (75/82), respectively. CONCLUSION: Although not better than CL (the distance of the odontoid tip above Chamberlain's line), measurement of CH at CT is reproducible and can diagnose patients with BI. SN - 1365-229X UR - https://www.unboundmedicine.com/medline/citation/27177855/Clivus_height_value:_a_new_diagnostic_method_for_basilar_invagination_at_CT_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009-9260(16)30044-7 DB - PRIME DP - Unbound Medicine ER -