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Chemical constituents from Inonotus obliquus and their antitumor activities.
J Nat Med. 2016 Oct; 70(4):721-30.JN

Abstract

Four new lanostane-type triterpenes (inonotusanes D-G, 1-4), including a 24,25,26,27-tetranorlanostane, together with 11 known compounds (5-15), including 7 lanostane derivatives, 2 steroids and 2 aromatic compounds, were isolated from the sclerotia of Inonotus obliquus. Their structures were elucidated by 1D and 2D NMR spectroscopy and HRMS. To our knowledge, 1 is the first 24,25,26,27-tetranorlanostane-type triterpenoid from fungus, and this is the first time that 31-member lanostane-type triterpenes, 5 and 6, have been isolated from the sclerotia of I. obliquus instead of from its submerged culture. 7 and 8 are also new isolates of this genus. Compounds 1, 8, 12 and 13 exhibited strong cytotoxicity against the 4T1 (mouse breast cancer) cell line, with IC50 9.40, 7.79, 9.06 and 9.31 μM, respectively. 8, 12 and 13 also exhibited strong cytotoxicity against the the MCF-7 (human breast cancer) cell line, with IC50 8.35-9.01 μM.

Authors+Show Affiliations

Department of Natural Products Chemistry, School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, China. Institute of Pharmacy, Henan University, Jinming Street, Kaifeng, 475004, China.Department of Natural Products Chemistry, School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, China. School of Chinese Materia Medica and Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin, 300193, China.Department of Natural Products Chemistry, School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, China.Institute of Pharmacy, Henan University, Jinming Street, Kaifeng, 475004, China.Institute of Pharmacy, Henan University, Jinming Street, Kaifeng, 475004, China.Department of Natural Products Chemistry, School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, China. fengqiu20070118@163.com. School of Chinese Materia Medica and Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin, 300193, China. fengqiu20070118@163.com.Institute of Pharmacy, Henan University, Jinming Street, Kaifeng, 475004, China. hanghang1998@126.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27180084

Citation

Zhao, Fenqin, et al. "Chemical Constituents From Inonotus Obliquus and Their Antitumor Activities." Journal of Natural Medicines, vol. 70, no. 4, 2016, pp. 721-30.
Zhao F, Xia G, Chen L, et al. Chemical constituents from Inonotus obliquus and their antitumor activities. J Nat Med. 2016;70(4):721-30.
Zhao, F., Xia, G., Chen, L., Zhao, J., Xie, Z., Qiu, F., & Han, G. (2016). Chemical constituents from Inonotus obliquus and their antitumor activities. Journal of Natural Medicines, 70(4), 721-30. https://doi.org/10.1007/s11418-016-1002-4
Zhao F, et al. Chemical Constituents From Inonotus Obliquus and Their Antitumor Activities. J Nat Med. 2016;70(4):721-30. PubMed PMID: 27180084.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chemical constituents from Inonotus obliquus and their antitumor activities. AU - Zhao,Fenqin, AU - Xia,Guiyang, AU - Chen,Lixia, AU - Zhao,Junli, AU - Xie,Zhanfang, AU - Qiu,Feng, AU - Han,Guang, Y1 - 2016/05/14/ PY - 2015/11/14/received PY - 2016/04/19/accepted PY - 2016/5/16/entrez PY - 2016/5/18/pubmed PY - 2017/3/23/medline KW - Antitumor KW - Inonotus obliquus KW - Inonotusane D KW - Inonotusane E KW - Inonotusane F KW - Inonotusane G KW - Triterpenoids SP - 721 EP - 30 JF - Journal of natural medicines JO - J Nat Med VL - 70 IS - 4 N2 - Four new lanostane-type triterpenes (inonotusanes D-G, 1-4), including a 24,25,26,27-tetranorlanostane, together with 11 known compounds (5-15), including 7 lanostane derivatives, 2 steroids and 2 aromatic compounds, were isolated from the sclerotia of Inonotus obliquus. Their structures were elucidated by 1D and 2D NMR spectroscopy and HRMS. To our knowledge, 1 is the first 24,25,26,27-tetranorlanostane-type triterpenoid from fungus, and this is the first time that 31-member lanostane-type triterpenes, 5 and 6, have been isolated from the sclerotia of I. obliquus instead of from its submerged culture. 7 and 8 are also new isolates of this genus. Compounds 1, 8, 12 and 13 exhibited strong cytotoxicity against the 4T1 (mouse breast cancer) cell line, with IC50 9.40, 7.79, 9.06 and 9.31 μM, respectively. 8, 12 and 13 also exhibited strong cytotoxicity against the the MCF-7 (human breast cancer) cell line, with IC50 8.35-9.01 μM. SN - 1861-0293 UR - https://www.unboundmedicine.com/medline/citation/27180084/Chemical_constituents_from_Inonotus_obliquus_and_their_antitumor_activities_ L2 - https://dx.doi.org/10.1007/s11418-016-1002-4 DB - PRIME DP - Unbound Medicine ER -