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Traditional Chinese medicine formulas for the treatment of osteoporosis: Implication for antiosteoporotic drug discovery.
J Ethnopharmacol 2016; 189:61-80JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

Osteoporosis is a chronic epidemic which can leads to enhanced bone fragility and consequent an increase in fracture risk. Traditional Chinese medicine (TCM) formulas have a long history of use in the prevention and treatment of osteoporosis. Antiosteoporotic TCM formulas have conspicuous advantage over single drugs. Systematic data mining of the existing antiosteoporotic TCM formulas database can certainly help the drug discovery processes and help the identification of safe candidates with synergistic formulations. In this review, the authors summarize the clinical use and animal experiments of TCM formulas and their mechanism of action, and discuss the potential antiosteoporotic activity and the active constituents of commonly used herbs in TCM formulas for the therapy of osteoporosis.

MATERIALS AND METHODS

The literature was searched from Medline, Pubmed, ScienceDirect, Spring Link, Web of Science, CNKI and VIP database from 1989 to 2015, and also collected from Chinese traditional books and Chinese Pharmacopoeia with key words such as osteoporosis, osteoblast, osteoclast, traditional Chinese medicine formulas to identify studies on the antiosteoporotic effects of TCM formulas, herbs and chemical constituents, and also their possible mechanisms.

RESULTS

Thirty-three TCM formulas were commonly used to treat osteoporosis, and showed significant antiosteoporotic effects in human and animal. The herb medicines and their chemical constituents in TCM formulas were summarized, the pharmacological effects and chemical constituents of commonly used herbs in TCM formulas were described in detail. The action mechanisms of TCM formulas and their chemical constituents were described. Finally, the implication for the discovery of antiosteoporotic leads and combinatory ingredients from TCM formulas were prospectively discussed.

CONCLUSIONS

Clinical practice and animal experiments indicate that TCM formulas provide a definite therapeutic effect on osteoporosis. The active constituents in TCM formulas are diverse in chemical structure, and include flavonoids, lignans, saponins and iridoid glycosides. Antiosteoporotic mechanism of TCM formulas and herbs involves multi regulatory pathways, such as Wnt/β-catenin, BMP/Smad, MAPK pathway and RANKL/OPG system. Phytochemicals from TCM formulas and their compositional herb medicines offer great potential for the development of novel antiosteoporotic drugs. The active ingredients in TCM formulas can be developed in combination as potent drugs, which may exhibit better antiosteoporotic effects compared to the individual compound.

Authors+Show Affiliations

Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China.Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China.Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China.Faculty of Science, School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Byrom Street, LiverpoolL3 3AF, UK.Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China.Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China.Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China.Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China. Electronic address: hailiangxin@163.com.Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China. Electronic address: zqy1965@163.com.Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

27180315

Citation

Zhang, Nai-Dan, et al. "Traditional Chinese Medicine Formulas for the Treatment of Osteoporosis: Implication for Antiosteoporotic Drug Discovery." Journal of Ethnopharmacology, vol. 189, 2016, pp. 61-80.
Zhang ND, Han T, Huang BK, et al. Traditional Chinese medicine formulas for the treatment of osteoporosis: Implication for antiosteoporotic drug discovery. J Ethnopharmacol. 2016;189:61-80.
Zhang, N. D., Han, T., Huang, B. K., Rahman, K., Jiang, Y. P., Xu, H. T., ... Li, Y. M. (2016). Traditional Chinese medicine formulas for the treatment of osteoporosis: Implication for antiosteoporotic drug discovery. Journal of Ethnopharmacology, 189, pp. 61-80. doi:10.1016/j.jep.2016.05.025.
Zhang ND, et al. Traditional Chinese Medicine Formulas for the Treatment of Osteoporosis: Implication for Antiosteoporotic Drug Discovery. J Ethnopharmacol. 2016 Aug 2;189:61-80. PubMed PMID: 27180315.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Traditional Chinese medicine formulas for the treatment of osteoporosis: Implication for antiosteoporotic drug discovery. AU - Zhang,Nai-Dan, AU - Han,Ting, AU - Huang,Bao-Kang, AU - Rahman,Khalid, AU - Jiang,Yi-Ping, AU - Xu,Hong-Tao, AU - Qin,Lu-Ping, AU - Xin,Hai-Liang, AU - Zhang,Qiao-Yan, AU - Li,Yi-Min, Y1 - 2016/05/11/ PY - 2015/10/27/received PY - 2016/04/19/revised PY - 2016/05/10/accepted PY - 2016/5/16/entrez PY - 2016/5/18/pubmed PY - 2017/4/21/medline KW - Action mechanism KW - Active ingredients KW - AsperosaponinⅥ (PubChem CID: 71307450) KW - Aucubin (PubChem CID: 91458) KW - Catalpol (PubChem CID: 91520) KW - Cinnamaldehyde (PubChem CID: 637511) KW - Clinical use KW - Ecdysterone (PubChem CID: 271605) KW - Emodin (PubChem CID: 3220) KW - Ferulic acid (PubChem CID: 445858) KW - Formononetin (PubChem CID: 5280378) KW - Kaempferol (PubChem CID: 5280863) KW - Osteoporosis KW - Sweroside (PubChem CID: 161036) KW - Traditional Chinese medicine formulas SP - 61 EP - 80 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 189 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: Osteoporosis is a chronic epidemic which can leads to enhanced bone fragility and consequent an increase in fracture risk. Traditional Chinese medicine (TCM) formulas have a long history of use in the prevention and treatment of osteoporosis. Antiosteoporotic TCM formulas have conspicuous advantage over single drugs. Systematic data mining of the existing antiosteoporotic TCM formulas database can certainly help the drug discovery processes and help the identification of safe candidates with synergistic formulations. In this review, the authors summarize the clinical use and animal experiments of TCM formulas and their mechanism of action, and discuss the potential antiosteoporotic activity and the active constituents of commonly used herbs in TCM formulas for the therapy of osteoporosis. MATERIALS AND METHODS: The literature was searched from Medline, Pubmed, ScienceDirect, Spring Link, Web of Science, CNKI and VIP database from 1989 to 2015, and also collected from Chinese traditional books and Chinese Pharmacopoeia with key words such as osteoporosis, osteoblast, osteoclast, traditional Chinese medicine formulas to identify studies on the antiosteoporotic effects of TCM formulas, herbs and chemical constituents, and also their possible mechanisms. RESULTS: Thirty-three TCM formulas were commonly used to treat osteoporosis, and showed significant antiosteoporotic effects in human and animal. The herb medicines and their chemical constituents in TCM formulas were summarized, the pharmacological effects and chemical constituents of commonly used herbs in TCM formulas were described in detail. The action mechanisms of TCM formulas and their chemical constituents were described. Finally, the implication for the discovery of antiosteoporotic leads and combinatory ingredients from TCM formulas were prospectively discussed. CONCLUSIONS: Clinical practice and animal experiments indicate that TCM formulas provide a definite therapeutic effect on osteoporosis. The active constituents in TCM formulas are diverse in chemical structure, and include flavonoids, lignans, saponins and iridoid glycosides. Antiosteoporotic mechanism of TCM formulas and herbs involves multi regulatory pathways, such as Wnt/β-catenin, BMP/Smad, MAPK pathway and RANKL/OPG system. Phytochemicals from TCM formulas and their compositional herb medicines offer great potential for the development of novel antiosteoporotic drugs. The active ingredients in TCM formulas can be developed in combination as potent drugs, which may exhibit better antiosteoporotic effects compared to the individual compound. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/27180315/Traditional_Chinese_medicine_formulas_for_the_treatment_of_osteoporosis:_Implication_for_antiosteoporotic_drug_discovery_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(16)30297-5 DB - PRIME DP - Unbound Medicine ER -