Abstract
The majority of the 30-100 million people infected with Strongyloides stercoralis, a soil transmitted intestinal nematode, have subclinical (or asymptomatic) infections. These infections are commonly chronic and longstanding because of the autoinfective process associated with its unique life cycle. A change in immune status can increase parasite numbers, leading to hyperinfection syndrome, dissemination, and death if unrecognized. Corticosteroid use and HTLV-1 infection are most commonly associated with the hyperinfection syndrome. Strongyloides adult parasites reside in the small intestine and induce immune responses both local and systemic that remain poorly characterized. Definitive diagnosis of S. stercoralis infection is based on stool examinations for larvae, but newer diagnostics - including new immunoassays and molecular tests - will assume primacy in the next few years. Although good treatment options exist for infection and control of this infection might be possible, S. stercoralis remains largely neglected.
TY - JOUR
T1 - Human infection with Strongyloides stercoralis and other related Strongyloides species.
A1 - Nutman,Thomas B,
Y1 - 2016/05/16/
PY - 2016/5/18/pubmed
PY - 2017/9/9/medline
PY - 2016/5/17/entrez
KW - Strongyloides stercoralis
KW - Strongyloidiasis
KW - anthelmintic therapy
KW - autoinfection
KW - corticosteroids
KW - hyperinfection
SP - 263
EP - 273
JF - Parasitology
JO - Parasitology
VL - 144
IS - 3
N2 - The majority of the 30-100 million people infected with Strongyloides stercoralis, a soil transmitted intestinal nematode, have subclinical (or asymptomatic) infections. These infections are commonly chronic and longstanding because of the autoinfective process associated with its unique life cycle. A change in immune status can increase parasite numbers, leading to hyperinfection syndrome, dissemination, and death if unrecognized. Corticosteroid use and HTLV-1 infection are most commonly associated with the hyperinfection syndrome. Strongyloides adult parasites reside in the small intestine and induce immune responses both local and systemic that remain poorly characterized. Definitive diagnosis of S. stercoralis infection is based on stool examinations for larvae, but newer diagnostics - including new immunoassays and molecular tests - will assume primacy in the next few years. Although good treatment options exist for infection and control of this infection might be possible, S. stercoralis remains largely neglected.
SN - 1469-8161
UR - https://www.unboundmedicine.com/medline/citation/27181117/full_citation
DB - PRIME
DP - Unbound Medicine
ER -
