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Changes in serum adipocyte fatty acid-binding protein in women with gestational diabetes mellitus and normal pregnant women during mid- and late pregnancy.
J Diabetes Investig. 2016 Sep; 7(5):797-804.JD

Abstract

AIMS/INTRODUCTION

To observe the longitudinal changes in serum adipocyte fatty acid-binding protein (AFABP), carbohydrate, and lipid metabolism parameters in women with and without gestational diabetes mellitus (GDM) during mid- and late pregnancy periods, as well as to identify whether there is any association between AFABP and development of GDM.

MATERIALS AND METHODS

A total of 40 GDM and 240 normal glucose tolerance participants were enrolled at 24-28 weeks and completed the study. The clinical features, serum AFABP, other adipocytokines (leptin, adiponectin, retinol-binding protein 4), homeostasis model assessment of insulin resistance, and lipid profiles were measured in the second and third trimesters of pregnancy.

RESULTS

Compared with the normal glucose tolerance group, the GDM group showed greater levels of AFABP, leptin and retinol-binding protein 4; and a decreased level of adiponectin (P < 0.05 or P < 0.01) during mid- and late pregnancy periods. Prepregnancy body mass index was the independent factor impacting serum AFABP levels in the second (β = 0.567, P = 0.004) and third trimesters (β = 0.619, P = 0.001). Furthermore, GDM was independently associated with AFABP concentrations in multiple regression analysis in the second and third trimester (all P < 0.01). Serum AFABP, leptin and retinol-binding protein 4 are risk factors for GDM; adiponectin is a protective factor for GDM (P < 0.05 or P < 0.01).

CONCLUSIONS

The GDM group had a higher level of AFABP during mid- and late stages of pregnancy; prepregnancy body mass index and GDM were the independent factors with respect to serum AFABP. AFABP might be closely related to obesity, insulin resistance and leptin resistance in pregnancy, and is a major risk factor for GDM.

Authors+Show Affiliations

Department of Endocrinology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. Key Laboratory for Major Obstetric Diseases of Guangdong Higher Education Institutes, Guangzhou, China.Department of Endocrinology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.Department of Endocrinology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.Department of Endocrinology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.Department of Endocrinology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27181269

Citation

Zhang, Ying, et al. "Changes in Serum Adipocyte Fatty Acid-binding Protein in Women With Gestational Diabetes Mellitus and Normal Pregnant Women During Mid- and Late Pregnancy." Journal of Diabetes Investigation, vol. 7, no. 5, 2016, pp. 797-804.
Zhang Y, Zhang HH, Lu JH, et al. Changes in serum adipocyte fatty acid-binding protein in women with gestational diabetes mellitus and normal pregnant women during mid- and late pregnancy. J Diabetes Investig. 2016;7(5):797-804.
Zhang, Y., Zhang, H. H., Lu, J. H., Zheng, S. Y., Long, T., Li, Y. T., Wu, W. Z., & Wang, F. (2016). Changes in serum adipocyte fatty acid-binding protein in women with gestational diabetes mellitus and normal pregnant women during mid- and late pregnancy. Journal of Diabetes Investigation, 7(5), 797-804. https://doi.org/10.1111/jdi.12484
Zhang Y, et al. Changes in Serum Adipocyte Fatty Acid-binding Protein in Women With Gestational Diabetes Mellitus and Normal Pregnant Women During Mid- and Late Pregnancy. J Diabetes Investig. 2016;7(5):797-804. PubMed PMID: 27181269.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Changes in serum adipocyte fatty acid-binding protein in women with gestational diabetes mellitus and normal pregnant women during mid- and late pregnancy. AU - Zhang,Ying, AU - Zhang,Hao-Hang, AU - Lu,Jia-Hui, AU - Zheng,Si-Yuan, AU - Long,Tao, AU - Li,Ying-Tao, AU - Wu,Wei-Zhen, AU - Wang,Fang, Y1 - 2016/02/24/ PY - 2015/07/30/received PY - 2015/11/30/revised PY - 2016/01/12/accepted PY - 2016/5/17/entrez PY - 2016/5/18/pubmed PY - 2017/2/18/medline KW - Adipocyte fatty acid binding protein KW - Adipocytokine KW - Gestational diabetes mellitus SP - 797 EP - 804 JF - Journal of diabetes investigation JO - J Diabetes Investig VL - 7 IS - 5 N2 - AIMS/INTRODUCTION: To observe the longitudinal changes in serum adipocyte fatty acid-binding protein (AFABP), carbohydrate, and lipid metabolism parameters in women with and without gestational diabetes mellitus (GDM) during mid- and late pregnancy periods, as well as to identify whether there is any association between AFABP and development of GDM. MATERIALS AND METHODS: A total of 40 GDM and 240 normal glucose tolerance participants were enrolled at 24-28 weeks and completed the study. The clinical features, serum AFABP, other adipocytokines (leptin, adiponectin, retinol-binding protein 4), homeostasis model assessment of insulin resistance, and lipid profiles were measured in the second and third trimesters of pregnancy. RESULTS: Compared with the normal glucose tolerance group, the GDM group showed greater levels of AFABP, leptin and retinol-binding protein 4; and a decreased level of adiponectin (P < 0.05 or P < 0.01) during mid- and late pregnancy periods. Prepregnancy body mass index was the independent factor impacting serum AFABP levels in the second (β = 0.567, P = 0.004) and third trimesters (β = 0.619, P = 0.001). Furthermore, GDM was independently associated with AFABP concentrations in multiple regression analysis in the second and third trimester (all P < 0.01). Serum AFABP, leptin and retinol-binding protein 4 are risk factors for GDM; adiponectin is a protective factor for GDM (P < 0.05 or P < 0.01). CONCLUSIONS: The GDM group had a higher level of AFABP during mid- and late stages of pregnancy; prepregnancy body mass index and GDM were the independent factors with respect to serum AFABP. AFABP might be closely related to obesity, insulin resistance and leptin resistance in pregnancy, and is a major risk factor for GDM. SN - 2040-1124 UR - https://www.unboundmedicine.com/medline/citation/27181269/Changes_in_serum_adipocyte_fatty_acid_binding_protein_in_women_with_gestational_diabetes_mellitus_and_normal_pregnant_women_during_mid__and_late_pregnancy_ L2 - https://doi.org/10.1111/jdi.12484 DB - PRIME DP - Unbound Medicine ER -