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Correlation between Helicobacter pylori-associated gastric diseases and colorectal neoplasia.
World J Gastroenterol. 2016 May 14; 22(18):4576-84.WJ

Abstract

AIM

To explore the correlation between Helicobacter pylori (H. pylori)-associated gastric diseases and colorectal neoplasia.

METHODS

Patients included in this study underwent a colonoscopy and esophago-gastro-duodenoscopy (EGD) along with histopathological measurement between March 2012 and March 2015 at Qi-Lu Hospital of Shandong University, who also had results of H. pylori detection. A total of 233 cases were selected. Demographic data, H. pylori infection status (including results of rapid urease tests and gastric mucosa pathological examinations) and histopathological examination results of gastric and colorectal mucosa were gathered and analyzed. The statistical analysis focused on the prevalence of colorectal neoplasms among patients with various histopathological categories of the stomach. ORs and their 95%CI were calculated to describe the strengths of the associations.

RESULTS

The incidence rates of colorectal adenoma without high-grade intraepithelial neoplasia (HGIEN) (OR = 2.400, 95%CI: 0.969-5.941), adenoma with HGIEN (5.333, 1.025-27.758) and adenocarcinoma (1.455, 0.382-5.543) were all higher for patients with H. pylori-associated gastritis than for those in the control group. The incidence rate of colorectal adenoma with HGIEN (3.218, 0.767-13.509) was higher in patients with intestinal metaplasia than in the control group, while the incidence rates of adenoma without HGIEN (0.874, 0.414-1.845) and adenocarcinoma (0.376, 0.096-1.470) were lower in the intestinal metaplasia group than in the control group. The incidence rate of colorectal adenoma without HGIEN (3.111, 1.248-7.753) was significantly higher in the gastric intraepithelial neoplasia group than in the control group, while the rates of adenoma with HGIEN (1.481, 0.138-15.941) and adenocarcinoma (2.020, 0.561-7.272) were higher in the gastric intraepithelial neoplasia group. Incidence rates of colorectal adenoma without HGIEN (1.067, 0.264-4.314), adenoma with HGIEN (2.667, 0.231-30.800) and adenocarcinoma (2.182, 0.450-10.585) were all higher in the gastric adenocarcinoma group than in the control group.

CONCLUSION

H. pylori infection as well as H. pylori-associated gastric diseases are risk factors for colorectal neoplasia.

Authors+Show Affiliations

Ying Qing, Min Wang, Lang Gao, Yan-Yan Liu, Teng-Fei Yin, Department of Geriatric Gastroenterology, Qi-Lu Hospital of Shandong University, Jinan 250012, Shandong Province, China.Ying Qing, Min Wang, Lang Gao, Yan-Yan Liu, Teng-Fei Yin, Department of Geriatric Gastroenterology, Qi-Lu Hospital of Shandong University, Jinan 250012, Shandong Province, China.Ying Qing, Min Wang, Lang Gao, Yan-Yan Liu, Teng-Fei Yin, Department of Geriatric Gastroenterology, Qi-Lu Hospital of Shandong University, Jinan 250012, Shandong Province, China.Ying Qing, Min Wang, Lang Gao, Yan-Yan Liu, Teng-Fei Yin, Department of Geriatric Gastroenterology, Qi-Lu Hospital of Shandong University, Jinan 250012, Shandong Province, China.Ying Qing, Min Wang, Lang Gao, Yan-Yan Liu, Teng-Fei Yin, Department of Geriatric Gastroenterology, Qi-Lu Hospital of Shandong University, Jinan 250012, Shandong Province, China.Ying Qing, Min Wang, Lang Gao, Yan-Yan Liu, Teng-Fei Yin, Department of Geriatric Gastroenterology, Qi-Lu Hospital of Shandong University, Jinan 250012, Shandong Province, China.Ying Qing, Min Wang, Lang Gao, Yan-Yan Liu, Teng-Fei Yin, Department of Geriatric Gastroenterology, Qi-Lu Hospital of Shandong University, Jinan 250012, Shandong Province, China.Ying Qing, Min Wang, Lang Gao, Yan-Yan Liu, Teng-Fei Yin, Department of Geriatric Gastroenterology, Qi-Lu Hospital of Shandong University, Jinan 250012, Shandong Province, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27182167

Citation

Qing, Ying, et al. "Correlation Between Helicobacter Pylori-associated Gastric Diseases and Colorectal Neoplasia." World Journal of Gastroenterology, vol. 22, no. 18, 2016, pp. 4576-84.
Qing Y, Wang M, Lin YM, et al. Correlation between Helicobacter pylori-associated gastric diseases and colorectal neoplasia. World J Gastroenterol. 2016;22(18):4576-84.
Qing, Y., Wang, M., Lin, Y. M., Wu, D., Zhu, J. Y., Gao, L., Liu, Y. Y., & Yin, T. F. (2016). Correlation between Helicobacter pylori-associated gastric diseases and colorectal neoplasia. World Journal of Gastroenterology, 22(18), 4576-84. https://doi.org/10.3748/wjg.v22.i18.4576
Qing Y, et al. Correlation Between Helicobacter Pylori-associated Gastric Diseases and Colorectal Neoplasia. World J Gastroenterol. 2016 May 14;22(18):4576-84. PubMed PMID: 27182167.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Correlation between Helicobacter pylori-associated gastric diseases and colorectal neoplasia. AU - Qing,Ying, AU - Wang,Min, AU - Lin,Ying-Min, AU - Wu,Dong, AU - Zhu,Jing-Yu, AU - Gao,Lang, AU - Liu,Yan-Yan, AU - Yin,Teng-Fei, PY - 2015/12/25/received PY - 2016/02/11/revised PY - 2016/03/01/accepted PY - 2016/5/17/entrez PY - 2016/5/18/pubmed PY - 2017/4/12/medline KW - Chinese population KW - Colorectal neoplasia KW - Endoscopy with pathological biopsy KW - Helicobacter pylori KW - Helicobacter pylori-associated gastric diseases SP - 4576 EP - 84 JF - World journal of gastroenterology JO - World J. Gastroenterol. VL - 22 IS - 18 N2 - AIM: To explore the correlation between Helicobacter pylori (H. pylori)-associated gastric diseases and colorectal neoplasia. METHODS: Patients included in this study underwent a colonoscopy and esophago-gastro-duodenoscopy (EGD) along with histopathological measurement between March 2012 and March 2015 at Qi-Lu Hospital of Shandong University, who also had results of H. pylori detection. A total of 233 cases were selected. Demographic data, H. pylori infection status (including results of rapid urease tests and gastric mucosa pathological examinations) and histopathological examination results of gastric and colorectal mucosa were gathered and analyzed. The statistical analysis focused on the prevalence of colorectal neoplasms among patients with various histopathological categories of the stomach. ORs and their 95%CI were calculated to describe the strengths of the associations. RESULTS: The incidence rates of colorectal adenoma without high-grade intraepithelial neoplasia (HGIEN) (OR = 2.400, 95%CI: 0.969-5.941), adenoma with HGIEN (5.333, 1.025-27.758) and adenocarcinoma (1.455, 0.382-5.543) were all higher for patients with H. pylori-associated gastritis than for those in the control group. The incidence rate of colorectal adenoma with HGIEN (3.218, 0.767-13.509) was higher in patients with intestinal metaplasia than in the control group, while the incidence rates of adenoma without HGIEN (0.874, 0.414-1.845) and adenocarcinoma (0.376, 0.096-1.470) were lower in the intestinal metaplasia group than in the control group. The incidence rate of colorectal adenoma without HGIEN (3.111, 1.248-7.753) was significantly higher in the gastric intraepithelial neoplasia group than in the control group, while the rates of adenoma with HGIEN (1.481, 0.138-15.941) and adenocarcinoma (2.020, 0.561-7.272) were higher in the gastric intraepithelial neoplasia group. Incidence rates of colorectal adenoma without HGIEN (1.067, 0.264-4.314), adenoma with HGIEN (2.667, 0.231-30.800) and adenocarcinoma (2.182, 0.450-10.585) were all higher in the gastric adenocarcinoma group than in the control group. CONCLUSION: H. pylori infection as well as H. pylori-associated gastric diseases are risk factors for colorectal neoplasia. SN - 2219-2840 UR - https://www.unboundmedicine.com/medline/citation/27182167/Correlation_between_Helicobacter_pylori_associated_gastric_diseases_and_colorectal_neoplasia_ L2 - http://www.wjgnet.com/1007-9327/full/v22/i18/4576.htm DB - PRIME DP - Unbound Medicine ER -