Citation
Morgan, Sophie B., et al. "Aerosol Delivery of a Candidate Universal Influenza Vaccine Reduces Viral Load in Pigs Challenged With Pandemic H1N1 Virus." Journal of Immunology (Baltimore, Md. : 1950), vol. 196, no. 12, 2016, pp. 5014-23.
Morgan SB, Hemmink JD, Porter E, et al. Aerosol Delivery of a Candidate Universal Influenza Vaccine Reduces Viral Load in Pigs Challenged with Pandemic H1N1 Virus. J Immunol. 2016;196(12):5014-23.
Morgan, S. B., Hemmink, J. D., Porter, E., Harley, R., Shelton, H., Aramouni, M., Everett, H. E., Brookes, S. M., Bailey, M., Townsend, A. M., Charleston, B., & Tchilian, E. (2016). Aerosol Delivery of a Candidate Universal Influenza Vaccine Reduces Viral Load in Pigs Challenged with Pandemic H1N1 Virus. Journal of Immunology (Baltimore, Md. : 1950), 196(12), 5014-23. https://doi.org/10.4049/jimmunol.1502632
Morgan SB, et al. Aerosol Delivery of a Candidate Universal Influenza Vaccine Reduces Viral Load in Pigs Challenged With Pandemic H1N1 Virus. J Immunol. 2016 06 15;196(12):5014-23. PubMed PMID: 27183611.
TY - JOUR
T1 - Aerosol Delivery of a Candidate Universal Influenza Vaccine Reduces Viral Load in Pigs Challenged with Pandemic H1N1 Virus.
AU - Morgan,Sophie B,
AU - Hemmink,Johanneke D,
AU - Porter,Emily,
AU - Harley,Ross,
AU - Shelton,Holly,
AU - Aramouni,Mario,
AU - Everett,Helen E,
AU - Brookes,Sharon M,
AU - Bailey,Michael,
AU - Townsend,Alain M,
AU - Charleston,Bryan,
AU - Tchilian,Elma,
Y1 - 2016/05/06/
PY - 2015/12/21/received
PY - 2016/04/11/accepted
PY - 2016/5/17/entrez
PY - 2016/5/18/pubmed
PY - 2017/8/2/medline
SP - 5014
EP - 23
JF - Journal of immunology (Baltimore, Md. : 1950)
JO - J Immunol
VL - 196
IS - 12
N2 - Influenza A viruses are a major health threat to livestock and humans, causing considerable mortality, morbidity, and economic loss. Current inactivated influenza vaccines are strain specific and new vaccines need to be produced at frequent intervals to combat newly arising influenza virus strains, so that a universal vaccine is highly desirable. We show that pandemic H1N1 influenza virus in which the hemagglutinin signal sequence has been suppressed (S-FLU), when administered to pigs by aerosol can induce CD4 and CD8 T cell immune responses in blood, bronchoalveolar lavage (BAL), and tracheobronchial lymph nodes. Neutralizing Ab was not produced. Detection of a BAL response correlated with a reduction in viral titer in nasal swabs and lungs, following challenge with H1N1 pandemic virus. Intratracheal immunization with a higher dose of a heterologous H5N1 S-FLU vaccine induced weaker BAL and stronger tracheobronchial lymph node responses and a lesser reduction in viral titer. We conclude that local cellular immune responses are important for protection against influenza A virus infection, that these can be most efficiently induced by aerosol immunization targeting the lower respiratory tract, and that S-FLU is a promising universal influenza vaccine candidate.
SN - 1550-6606
UR - https://www.unboundmedicine.com/medline/citation/27183611/Aerosol_Delivery_of_a_Candidate_Universal_Influenza_Vaccine_Reduces_Viral_Load_in_Pigs_Challenged_with_Pandemic_H1N1_Virus_
DB - PRIME
DP - Unbound Medicine
ER -
