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[Dynamic maternal measles antibody level in infants: a longitudinal study].
Zhonghua Liu Xing Bing Xue Za Zhi. 2016 May; 37(5):663-7.ZL

Abstract

OBJECTIVE

To understand the dynamic maternal measles antibody level in infants in Guangzhou.

METHOD

Women who delivered babies in a maternal and child health care hospital in Guangzhou and their infants who were never affected by measles were included in our study. All the serum samples collected from mothers and infants were tested by using enzyme linked immunosorbent assay(ELISA)for the quantitative measurement of measles IgG antibodies. A longitudinal sero-epidemiological study was conducted to investigate the duration of the presence of measles maternal antibodies in infants based on the measurement at different time points(0, 3, 5, 7 month).

RESULT

A total of 689 mothers and their 691 infants(two pairs of twins)were included in the study. The concentration and the sero-positivity rate of measles antibody in mothers was 513.8 mIU/ml and 81.6% respectively. The concentration and the sero-positivity rate of measles antibody in infants was 732.8 mIU/ml and 87.3%, respectively. The measles antibody levels of newborns were positively associated with those of mothers(r=0.917 5, P<0.001), which declined rapidly at 3 months after birth and mostly turned to be negative at 7 months after birth. Measles antibody turned be negative at 3 months after birth in low, middle level groups, but remained to be positive in high level group at 5 months after birth.

CONCLUSION

The maternal measles antibody could rarely protect infants at age of 8 months even though mother had been vaccinated or acquired natural immunity. It is suggested to adjust the time of the first dose measles vaccination in infants and increase the measles antibody level of child bearing aged women to reduce the incidence of measles in infants.

Authors+Show Affiliations

Director Office, Liwan District Center for Disease Control and Prevention, Guangzhou 510176, China.Virology and Immunology Laboratory, Guangzhou Municipal Center for Disease Control and Prevention, Guangzhou 510440, China.Department of AIDS/STD Control and Prevention, Guangzhou Municipal Center for Disease Control and Prevention, Guangzhou 510440, China.Department of Immunization Program, Guangzhou Municipal Center for Disease Control and Prevention, Guangzhou 510440, China.Executive Office for Managing Action in Disease Control and Prevention, Guangzhou Municipal Center for Disease Control and Prevention, Guangzhou 510440, China.Virology and Immunology Laboratory, Guangzhou Municipal Center for Disease Control and Prevention, Guangzhou 510440, China.Department of Primary Public Health, Guangzhou Municipal Center for Disease Control and Prevention, Guangzhou 510440, China.Director Office, Guangzhou Municipal Center for Disease Control and Prevention, Guangzhou 510440, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

27188358

Citation

Lu, L, et al. "[Dynamic Maternal Measles Antibody Level in Infants: a Longitudinal Study]." Zhonghua Liu Xing Bing Xue Za Zhi = Zhonghua Liuxingbingxue Zazhi, vol. 37, no. 5, 2016, pp. 663-7.
Lu L, Cao YM, Yang QY, et al. [Dynamic maternal measles antibody level in infants: a longitudinal study]. Zhonghua Liu Xing Bing Xue Za Zhi. 2016;37(5):663-7.
Lu, L., Cao, Y. M., Yang, Q. Y., He, Q., Dong, Z. Q., Di, B., Fu, C. X., & Wang, M. (2016). [Dynamic maternal measles antibody level in infants: a longitudinal study]. Zhonghua Liu Xing Bing Xue Za Zhi = Zhonghua Liuxingbingxue Zazhi, 37(5), 663-7. https://doi.org/10.3760/cma.j.issn.0254-6450.2016.05.015
Lu L, et al. [Dynamic Maternal Measles Antibody Level in Infants: a Longitudinal Study]. Zhonghua Liu Xing Bing Xue Za Zhi. 2016;37(5):663-7. PubMed PMID: 27188358.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Dynamic maternal measles antibody level in infants: a longitudinal study]. AU - Lu,L, AU - Cao,Y M, AU - Yang,Q Y, AU - He,Q, AU - Dong,Z Q, AU - Di,B, AU - Fu,C X, AU - Wang,M, PY - 2016/5/19/entrez PY - 2016/5/18/pubmed PY - 2017/1/11/medline SP - 663 EP - 7 JF - Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi JO - Zhonghua Liu Xing Bing Xue Za Zhi VL - 37 IS - 5 N2 - OBJECTIVE: To understand the dynamic maternal measles antibody level in infants in Guangzhou. METHOD: Women who delivered babies in a maternal and child health care hospital in Guangzhou and their infants who were never affected by measles were included in our study. All the serum samples collected from mothers and infants were tested by using enzyme linked immunosorbent assay(ELISA)for the quantitative measurement of measles IgG antibodies. A longitudinal sero-epidemiological study was conducted to investigate the duration of the presence of measles maternal antibodies in infants based on the measurement at different time points(0, 3, 5, 7 month). RESULT: A total of 689 mothers and their 691 infants(two pairs of twins)were included in the study. The concentration and the sero-positivity rate of measles antibody in mothers was 513.8 mIU/ml and 81.6% respectively. The concentration and the sero-positivity rate of measles antibody in infants was 732.8 mIU/ml and 87.3%, respectively. The measles antibody levels of newborns were positively associated with those of mothers(r=0.917 5, P<0.001), which declined rapidly at 3 months after birth and mostly turned to be negative at 7 months after birth. Measles antibody turned be negative at 3 months after birth in low, middle level groups, but remained to be positive in high level group at 5 months after birth. CONCLUSION: The maternal measles antibody could rarely protect infants at age of 8 months even though mother had been vaccinated or acquired natural immunity. It is suggested to adjust the time of the first dose measles vaccination in infants and increase the measles antibody level of child bearing aged women to reduce the incidence of measles in infants. SN - 0254-6450 UR - https://www.unboundmedicine.com/medline/citation/27188358/[Dynamic_maternal_measles_antibody_level_in_infants:_a_longitudinal_study]_ DB - PRIME DP - Unbound Medicine ER -