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Chamomile infusion cryotherapy to prevent oral mucositis induced by chemotherapy: a pilot study.
Support Care Cancer. 2016 10; 24(10):4393-8.SC

Abstract

PURPOSE

The aim of this study is to compare cryotherapy made only with water and cryotherapy made with chamomile infusion for prevention and reduction of intensity of oral mucositis in patients with cancer receiving 5-fluorouracil and leucovorin.

METHOD

This is a randomized pilot study with two groups: cryotherapy made only with water (control group, n = 18) and cryotherapy made with chamomile infusion (chamomile group, n = 20). Both groups were instructed to swish the ice around in their oral cavity for at least 30 min during chemotherapy. Assessment of oral mucosa occurred on days 8, 15, and 22 after the first day of chemotherapy.

RESULTS

Fifty percent of the patients in the control and 30 % in the chamomile group developed oral mucositis. Mouth pain score was higher in patients in the control group on all evaluations (p = 0.02 for day 8, p = 0.09 for day 15, and p = 0.14 for day 22). Patients in the chamomile group never developed mucositis with grade 2 or higher. Presence of ulceration was statistically significant on day 8 (16 % in the control vs. 0 % in the chamomile group, p = 0.10), but not in days 15 and 22, although 11 % still had ulcerations in the control group and none in the chamomile group.

CONCLUSION

The occurrence of oral mucositis was lower in patients in the chamomile group than in the control group. When compared to the controls, the chamomile group presented less mouth pain and had no ulcerations. Cryotherapy was well tolerated by both groups, and no toxicity related to chamomile was identified.

Authors+Show Affiliations

Nursing Department, School of Health Sciences, University of Brasília, Darcy Ribeiro University Campus, Asa Norte, Brasilia, Federal District, 71100-070, Brazil. pauladiniz@unb.br.Department of Rehabilitation Medicine, School of Medicine, University of Washington, Seattle, WA, USA.Dentistry Department, School of Health Sciences, University of Brasília, Brasília, DF, Brazil.Dentistry Department, School of Health Sciences, University of Brasília, Brasília, DF, Brazil.Dentistry Department, School of Health Sciences, University of Brasília, Brasília, DF, Brazil.Medical Department, Senado Federal, Brasília, DF, Brazil.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

27189615

Citation

Dos Reis, Paula Elaine Diniz, et al. "Chamomile Infusion Cryotherapy to Prevent Oral Mucositis Induced By Chemotherapy: a Pilot Study." Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer, vol. 24, no. 10, 2016, pp. 4393-8.
Dos Reis PE, Ciol MA, de Melo NS, et al. Chamomile infusion cryotherapy to prevent oral mucositis induced by chemotherapy: a pilot study. Support Care Cancer. 2016;24(10):4393-8.
Dos Reis, P. E., Ciol, M. A., de Melo, N. S., Figueiredo, P. T., Leite, A. F., & Manzi, N. d. e. . M. (2016). Chamomile infusion cryotherapy to prevent oral mucositis induced by chemotherapy: a pilot study. Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer, 24(10), 4393-8. https://doi.org/10.1007/s00520-016-3279-y
Dos Reis PE, et al. Chamomile Infusion Cryotherapy to Prevent Oral Mucositis Induced By Chemotherapy: a Pilot Study. Support Care Cancer. 2016;24(10):4393-8. PubMed PMID: 27189615.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chamomile infusion cryotherapy to prevent oral mucositis induced by chemotherapy: a pilot study. AU - Dos Reis,Paula Elaine Diniz, AU - Ciol,Marcia A, AU - de Melo,Nilce Santos, AU - Figueiredo,Paulo Tadeu de Souza, AU - Leite,André Ferreira, AU - Manzi,Natália de Melo, Y1 - 2016/05/17/ PY - 2016/01/31/received PY - 2016/05/10/accepted PY - 2016/5/19/entrez PY - 2016/5/18/pubmed PY - 2017/10/14/medline KW - Cancer KW - Chemotherapy KW - Cryotherapy KW - Oral care KW - Oral mucositis SP - 4393 EP - 8 JF - Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer JO - Support Care Cancer VL - 24 IS - 10 N2 - PURPOSE: The aim of this study is to compare cryotherapy made only with water and cryotherapy made with chamomile infusion for prevention and reduction of intensity of oral mucositis in patients with cancer receiving 5-fluorouracil and leucovorin. METHOD: This is a randomized pilot study with two groups: cryotherapy made only with water (control group, n = 18) and cryotherapy made with chamomile infusion (chamomile group, n = 20). Both groups were instructed to swish the ice around in their oral cavity for at least 30 min during chemotherapy. Assessment of oral mucosa occurred on days 8, 15, and 22 after the first day of chemotherapy. RESULTS: Fifty percent of the patients in the control and 30 % in the chamomile group developed oral mucositis. Mouth pain score was higher in patients in the control group on all evaluations (p = 0.02 for day 8, p = 0.09 for day 15, and p = 0.14 for day 22). Patients in the chamomile group never developed mucositis with grade 2 or higher. Presence of ulceration was statistically significant on day 8 (16 % in the control vs. 0 % in the chamomile group, p = 0.10), but not in days 15 and 22, although 11 % still had ulcerations in the control group and none in the chamomile group. CONCLUSION: The occurrence of oral mucositis was lower in patients in the chamomile group than in the control group. When compared to the controls, the chamomile group presented less mouth pain and had no ulcerations. Cryotherapy was well tolerated by both groups, and no toxicity related to chamomile was identified. SN - 1433-7339 UR - https://www.unboundmedicine.com/medline/citation/27189615/Chamomile_infusion_cryotherapy_to_prevent_oral_mucositis_induced_by_chemotherapy:_a_pilot_study_ L2 - https://dx.doi.org/10.1007/s00520-016-3279-y DB - PRIME DP - Unbound Medicine ER -