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Middle East Respiratory Syndrome Coronavirus Transmission in Extended Family, Saudi Arabia, 2014.
Emerg Infect Dis. 2016 08; 22(8):1395-402.EI

Abstract

Risk factors for human-to-human transmission of Middle East respiratory syndrome coronavirus (MERS-CoV) are largely unknown. After MERS-CoV infections occurred in an extended family in Saudi Arabia in 2014, relatives were tested by using real-time reverse transcription PCR (rRT-PCR) and serologic methods. Among 79 relatives, 19 (24%) were MERS-CoV positive; 11 were hospitalized, and 2 died. Eleven (58%) tested positive by rRT-PCR; 8 (42%) tested negative by rRT-PCR but positive by serology. Compared with MERS-CoV-negative adult relatives, MERS-CoV-positive adult relatives were older and more likely to be male and to have chronic medical conditions. Risk factors for household transmission included sleeping in an index patient's room and touching respiratory secretions from an index patient. Casual contact and simple proximity were not associated with transmission. Serology was more sensitive than standard rRT-PCR for identifying infected relatives, highlighting the value of including serology in future investigations.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

27191038

Citation

Arwady, M Allison, et al. "Middle East Respiratory Syndrome Coronavirus Transmission in Extended Family, Saudi Arabia, 2014." Emerging Infectious Diseases, vol. 22, no. 8, 2016, pp. 1395-402.
Arwady MA, Alraddadi B, Basler C, et al. Middle East Respiratory Syndrome Coronavirus Transmission in Extended Family, Saudi Arabia, 2014. Emerg Infect Dis. 2016;22(8):1395-402.
Arwady, M. A., Alraddadi, B., Basler, C., Azhar, E. I., Abuelzein, E., Sindy, A. I., Sadiq, B. M., Althaqafi, A. O., Shabouni, O., Banjar, A., Haynes, L. M., Gerber, S. I., Feikin, D. R., & Madani, T. A. (2016). Middle East Respiratory Syndrome Coronavirus Transmission in Extended Family, Saudi Arabia, 2014. Emerging Infectious Diseases, 22(8), 1395-402. https://doi.org/10.3201/eid2208.152015
Arwady MA, et al. Middle East Respiratory Syndrome Coronavirus Transmission in Extended Family, Saudi Arabia, 2014. Emerg Infect Dis. 2016;22(8):1395-402. PubMed PMID: 27191038.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Middle East Respiratory Syndrome Coronavirus Transmission in Extended Family, Saudi Arabia, 2014. AU - Arwady,M Allison, AU - Alraddadi,Basem, AU - Basler,Colin, AU - Azhar,Esam I, AU - Abuelzein,Eltayb, AU - Sindy,Abdulfattah I, AU - Sadiq,Bakr M Bin, AU - Althaqafi,Abdulhakeem O, AU - Shabouni,Omaima, AU - Banjar,Ayman, AU - Haynes,Lia M, AU - Gerber,Susan I, AU - Feikin,Daniel R, AU - Madani,Tariq A, Y1 - 2016/08/15/ PY - 2016/5/19/entrez PY - 2016/5/19/pubmed PY - 2018/1/9/medline KW - Middle East respiratory syndrome coronavirus KW - RT-PCR KW - Saudi Arabia KW - disease transmission KW - infectious KW - serologic tests KW - viruses SP - 1395 EP - 402 JF - Emerging infectious diseases JO - Emerg Infect Dis VL - 22 IS - 8 N2 - Risk factors for human-to-human transmission of Middle East respiratory syndrome coronavirus (MERS-CoV) are largely unknown. After MERS-CoV infections occurred in an extended family in Saudi Arabia in 2014, relatives were tested by using real-time reverse transcription PCR (rRT-PCR) and serologic methods. Among 79 relatives, 19 (24%) were MERS-CoV positive; 11 were hospitalized, and 2 died. Eleven (58%) tested positive by rRT-PCR; 8 (42%) tested negative by rRT-PCR but positive by serology. Compared with MERS-CoV-negative adult relatives, MERS-CoV-positive adult relatives were older and more likely to be male and to have chronic medical conditions. Risk factors for household transmission included sleeping in an index patient's room and touching respiratory secretions from an index patient. Casual contact and simple proximity were not associated with transmission. Serology was more sensitive than standard rRT-PCR for identifying infected relatives, highlighting the value of including serology in future investigations. SN - 1080-6059 UR - https://www.unboundmedicine.com/medline/citation/27191038/Middle_East_Respiratory_Syndrome_Coronavirus_Transmission_in_Extended_Family_Saudi_Arabia_2014_ L2 - https://doi.org/10.3201/eid2208.152015 DB - PRIME DP - Unbound Medicine ER -