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Are 2D:4D finger-length ratios an indicator of androgenetic alopecia in males?
An Bras Dermatol. 2016 Apr; 91(2):156-9.AB

Abstract

BACKGROUND

Although the pathogenesis of androgenetic alopecia is not completely understood, the roles of genetic susceptibility and androgens are well-known. A lower ratio of the second digit (index finger = 2D) to the fourth digit (ring finger = 4D) length has been hypothesized to reflect prenatal androgen exposure and/or higher sensitivity to androgens.

OBJECTIVES

To determine the relationship between the second to fourth digit length ratio and androgenetic alopecia.

METHODS

Finger length measurements were made by a digital vernier calliper. Androgenetic alopecia severity was assessed using the Hamilton-Norwood scale. Subjects with an androgenetic alopecia score of grade III or more were included in the study.

RESULTS

A total of 189 males with androgenetic alopecia and 171 healthy controls were enrolled in the study. The age range of participants was 19-65 years. The 2D:4D ratios in patients with androgenetic alopecia were significantly lower than those of healthy controls for the right hand; however, no significant difference was found for the left hand. Average 2D:4D ratios in androgenetic alopecia patients were also lower than in controls. No significant relationship was observed between androgenetic alopecia severity and 2D:4D ratios.

CONCLUSION

Our data support the anatomical evidence of in utero androgen exposure and/or an individual's sensitivity to androgens in patients with androgenetic alopecia. Furthermore, the right hand 2D:4D ratio might be an indicator of androgenetic alopecia development.

Authors+Show Affiliations

Selcuk University, Konya, Turkey.Selcuk University, Konya, Turkey.Selcuk University, Konya, Turkey.Selcuk University, Konya, Turkey.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27192513

Citation

Bilgic, Özlem, et al. "Are 2D:4D Finger-length Ratios an Indicator of Androgenetic Alopecia in Males?" Anais Brasileiros De Dermatologia, vol. 91, no. 2, 2016, pp. 156-9.
Bilgic Ö, Altınyazar HC, Eryılmaz D, et al. Are 2D:4D finger-length ratios an indicator of androgenetic alopecia in males? An Bras Dermatol. 2016;91(2):156-9.
Bilgic, Ö., Altınyazar, H. C., Eryılmaz, D., & Tuğrul, Z. A. (2016). Are 2D:4D finger-length ratios an indicator of androgenetic alopecia in males? Anais Brasileiros De Dermatologia, 91(2), 156-9. https://doi.org/10.1590/abd1806-4841.20164622
Bilgic Ö, et al. Are 2D:4D Finger-length Ratios an Indicator of Androgenetic Alopecia in Males. An Bras Dermatol. 2016;91(2):156-9. PubMed PMID: 27192513.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Are 2D:4D finger-length ratios an indicator of androgenetic alopecia in males? AU - Bilgic,Özlem, AU - Altınyazar,Hilmi Cevdet, AU - Eryılmaz,Dilek, AU - Tuğrul,Zehra Ayça, PY - 2015/04/07/received PY - 2015/06/21/accepted PY - 2016/5/19/entrez PY - 2016/5/19/pubmed PY - 2017/3/23/medline SP - 156 EP - 9 JF - Anais brasileiros de dermatologia JO - An Bras Dermatol VL - 91 IS - 2 N2 - BACKGROUND: Although the pathogenesis of androgenetic alopecia is not completely understood, the roles of genetic susceptibility and androgens are well-known. A lower ratio of the second digit (index finger = 2D) to the fourth digit (ring finger = 4D) length has been hypothesized to reflect prenatal androgen exposure and/or higher sensitivity to androgens. OBJECTIVES: To determine the relationship between the second to fourth digit length ratio and androgenetic alopecia. METHODS: Finger length measurements were made by a digital vernier calliper. Androgenetic alopecia severity was assessed using the Hamilton-Norwood scale. Subjects with an androgenetic alopecia score of grade III or more were included in the study. RESULTS: A total of 189 males with androgenetic alopecia and 171 healthy controls were enrolled in the study. The age range of participants was 19-65 years. The 2D:4D ratios in patients with androgenetic alopecia were significantly lower than those of healthy controls for the right hand; however, no significant difference was found for the left hand. Average 2D:4D ratios in androgenetic alopecia patients were also lower than in controls. No significant relationship was observed between androgenetic alopecia severity and 2D:4D ratios. CONCLUSION: Our data support the anatomical evidence of in utero androgen exposure and/or an individual's sensitivity to androgens in patients with androgenetic alopecia. Furthermore, the right hand 2D:4D ratio might be an indicator of androgenetic alopecia development. SN - 1806-4841 UR - https://www.unboundmedicine.com/medline/citation/27192513/Are_2D:4D_finger_length_ratios_an_indicator_of_androgenetic_alopecia_in_males L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/27192513/ DB - PRIME DP - Unbound Medicine ER -