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Short-term ubiquinol supplementation reduces oxidative stress associated with strenuous exercise in healthy adults: A randomized trial.
Biofactors. 2016 Nov 12; 42(6):612-622.B

Abstract

Studies about Coenzyme Q10 (CoQ10) supplementation on strenuous exercise are scarce, especially those related with oxidative stress associated with physical activity and virtually nonexistent with the reduced form, Ubiquinol. The objective of this study was to determine, for the first time, whether a short-term supplementation with Ubiquinol can prevent oxidative stress associated to strenuous exercise. The participants (n = 100 healthy and well trained, but not on an elite level) were classified in two groups: Ubiquinol (experimental group), and placebo group (control). The protocol consisted of conducting two identical strenuous exercise tests with a rest period between tests of 24 h. Blood and urine samples were collected from the participants before supplementation (basal value) (T1), after supplementation (2 weeks) (T2), after first physical exercise test (T3), after 24 h of rest (T4), and after second physical exercise test (T5).The increase observed in the lactate, isoprostanes, DNA damage, and hydroperoxide levels reveals the severity of the oxidative damage induced by the exercise. There was a reduction in the isoprostanes, 8-OHdG, oxidized LDL, and hydroperoxydes in the supplemented Ubiquinol group, an increase in total antioxidant status, fat soluble antioxidant (both plasma and membrane), and CAT activity. Also, NO in the Ubiquinol-supplemented group was maintained within a narrow range. Oxidative stress induced by strenuous exercise is accumulative and increases transiently in subsequent sessions of physical activity. A short-term supplementation (2 weeks) with Ubiquinol (200 mg/day) before strenuous exercise, decreases oxidative stress and increases plasma NO, fact that could improve endothelial function, energetic substrate supply, and muscle recovery after strenuous exercise. © 2016 BioFactors, 42(6):612-622, 2016.

Authors+Show Affiliations

Institute of Nutrition and Food Technology "José Mataix," University of Granada, Granada, Spain. Human Nutrition Ph.D. Program, University of Granada, Granada, Spain.Institute of Nutrition and Food Technology "José Mataix," University of Granada, Granada, Spain. Department of Physiology, University of Granada, Granada, Spain.Institute of Nutrition and Food Technology "José Mataix," University of Granada, Granada, Spain. Department of Biochemistry and Molecular Biology II, University of Granada, Granada, Spain.Institute of Nutrition and Food Technology "José Mataix," University of Granada, Granada, Spain. Department of Physiology, University of Granada, Granada, Spain.Institute of Nutrition and Food Technology "José Mataix," University of Granada, Granada, Spain. Department of Physiology, University of Granada, Granada, Spain.Departament of Physical Education, University of Granada, Granada, Spain.Faculty of Health Sciences, University of Granada, Granada, Spain.Departament of Physical Education, University of Granada, Granada, Spain.Faculty of Health Sciences, University of Granada, Granada, Spain.Institute of Nutrition and Food Technology "José Mataix," University of Granada, Granada, Spain. Department of Physiology, University of Granada, Granada, Spain.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

27193497

Citation

Sarmiento, Alvaro, et al. "Short-term Ubiquinol Supplementation Reduces Oxidative Stress Associated With Strenuous Exercise in Healthy Adults: a Randomized Trial." BioFactors (Oxford, England), vol. 42, no. 6, 2016, pp. 612-622.
Sarmiento A, Diaz-Castro J, Pulido-Moran M, et al. Short-term ubiquinol supplementation reduces oxidative stress associated with strenuous exercise in healthy adults: A randomized trial. Biofactors. 2016;42(6):612-622.
Sarmiento, A., Diaz-Castro, J., Pulido-Moran, M., Moreno-Fernandez, J., Kajarabille, N., Chirosa, I., Guisado, I. M., Javier Chirosa, L., Guisado, R., & Ochoa, J. J. (2016). Short-term ubiquinol supplementation reduces oxidative stress associated with strenuous exercise in healthy adults: A randomized trial. BioFactors (Oxford, England), 42(6), 612-622. https://doi.org/10.1002/biof.1297
Sarmiento A, et al. Short-term Ubiquinol Supplementation Reduces Oxidative Stress Associated With Strenuous Exercise in Healthy Adults: a Randomized Trial. Biofactors. 2016 Nov 12;42(6):612-622. PubMed PMID: 27193497.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Short-term ubiquinol supplementation reduces oxidative stress associated with strenuous exercise in healthy adults: A randomized trial. AU - Sarmiento,Alvaro, AU - Diaz-Castro,Javier, AU - Pulido-Moran,Mario, AU - Moreno-Fernandez,Jorge, AU - Kajarabille,Naroa, AU - Chirosa,Ignacio, AU - Guisado,Isabel M, AU - Javier Chirosa,Luis, AU - Guisado,Rafael, AU - Ochoa,Julio J, Y1 - 2016/05/19/ PY - 2016/03/09/received PY - 2016/04/04/revised PY - 2016/04/19/accepted PY - 2016/5/20/pubmed PY - 2017/2/1/medline PY - 2016/5/20/entrez KW - Ubiquinol KW - high intensity (strenuous) exercise KW - oxidative damage SP - 612 EP - 622 JF - BioFactors (Oxford, England) JO - Biofactors VL - 42 IS - 6 N2 - Studies about Coenzyme Q10 (CoQ10) supplementation on strenuous exercise are scarce, especially those related with oxidative stress associated with physical activity and virtually nonexistent with the reduced form, Ubiquinol. The objective of this study was to determine, for the first time, whether a short-term supplementation with Ubiquinol can prevent oxidative stress associated to strenuous exercise. The participants (n = 100 healthy and well trained, but not on an elite level) were classified in two groups: Ubiquinol (experimental group), and placebo group (control). The protocol consisted of conducting two identical strenuous exercise tests with a rest period between tests of 24 h. Blood and urine samples were collected from the participants before supplementation (basal value) (T1), after supplementation (2 weeks) (T2), after first physical exercise test (T3), after 24 h of rest (T4), and after second physical exercise test (T5).The increase observed in the lactate, isoprostanes, DNA damage, and hydroperoxide levels reveals the severity of the oxidative damage induced by the exercise. There was a reduction in the isoprostanes, 8-OHdG, oxidized LDL, and hydroperoxydes in the supplemented Ubiquinol group, an increase in total antioxidant status, fat soluble antioxidant (both plasma and membrane), and CAT activity. Also, NO in the Ubiquinol-supplemented group was maintained within a narrow range. Oxidative stress induced by strenuous exercise is accumulative and increases transiently in subsequent sessions of physical activity. A short-term supplementation (2 weeks) with Ubiquinol (200 mg/day) before strenuous exercise, decreases oxidative stress and increases plasma NO, fact that could improve endothelial function, energetic substrate supply, and muscle recovery after strenuous exercise. © 2016 BioFactors, 42(6):612-622, 2016. SN - 1872-8081 UR - https://www.unboundmedicine.com/medline/citation/27193497/Short_term_ubiquinol_supplementation_reduces_oxidative_stress_associated_with_strenuous_exercise_in_healthy_adults:_A_randomized_trial_ L2 - https://doi.org/10.1002/biof.1297 DB - PRIME DP - Unbound Medicine ER -