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Clinical features of bipolar spectrum with binge eating behaviour.
J Affect Disord. 2016 Sep 01; 201:95-8.JA

Abstract

OBJECTIVE

To determine whether bipolar spectrum disorder with binge eating behavior (BE) is an important clinical sub-phenotype.

METHODS

Prevalence rates and correlates of different levels of BE were assessed in 1114 bipolar spectrum patients participating in a genetic biobank. BE and eating disorders (EDs) were assessed with the Eating Disorder Diagnostic Scale (EDDS). Psychiatric illness burden was evaluated with measures of suicidality, psychosis, mood instability, anxiety disorder comorbidity, and substance abuse comorbidity. Medical illness burden was evaluated with body mass index (BMI) and the Cumulative Index Rating Scale (CIRS).

RESULTS

Thirty percent of patients had any BE and 27% had BE plus an ED diagnosis. Compared with bipolar spectrum patients without BE, bipolar spectrum patients with BE were younger and more likely to be female; had significantly higher levels of eating psychopathology, suicidality, mood instability, and anxiety disorder comorbidity; had a significantly higher mean BMI and a significantly higher rate of obesity; and had a significantly higher medical illness burden. Bipolar spectrum patients with BE but no ED diagnosis were more similar to bipolar spectrum patients without BE than to those with an ED. Nonetheless, the positive predictive value and specificity of BE predicting an ED was 0.90 and 0.96, respectively.

LIMITATIONS

As only two patients had co-occurring anorexia nervosa, these results may not generalize to bipolar spectrum patients with restricting EDs.

CONCLUSION

Bipolar spectrum disorder with broadly-defined BE may not be as clinically relevant a sub-phenotype as bipolar spectrum disorder with an ED but may be an adequate proxy for the latter when phenotyping large samples of individuals.

Authors+Show Affiliations

Lindner Center of HOPE, 4075 Old Western Row Road, Mason, OH 45040, USA; Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA. Electronic address: susan.mcelroy@lindnercenter.org.Department of Psychiatry, University of Minnesota Medical School, Minneapolis, MN, USA; The Emily Program, St. Paul, MN, USA.Lindner Center of HOPE, 4075 Old Western Row Road, Mason, OH 45040, USA; Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA.Department of Psychiatry, Universidad Autonoma de Nuevo Leon, Monterrey, Mexico.Universidad de los Andes, Facultad de Medicina, Departamento de Psiquiatría, Santiago, Chile.Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, MN, USA.Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN, USA.Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, MN, USA.Department of Psychiatry, Universidad Autonoma de Nuevo Leon, Monterrey, Mexico.Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, MN, USA.Lindner Center of HOPE, 4075 Old Western Row Road, Mason, OH 45040, USA; Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA.Department of Psychiatry, University of Minnesota Medical School, Minneapolis, MN, USA.Department of Psychiatry, Universidad Autonoma de Nuevo Leon, Monterrey, Mexico; Universidad de los Andes, Facultad de Medicina, Departamento de Psiquiatría, Santiago, Chile.Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, MN, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27195513

Citation

McElroy, Susan L., et al. "Clinical Features of Bipolar Spectrum With Binge Eating Behaviour." Journal of Affective Disorders, vol. 201, 2016, pp. 95-8.
McElroy SL, Crow S, Blom TJ, et al. Clinical features of bipolar spectrum with binge eating behaviour. J Affect Disord. 2016;201:95-8.
McElroy, S. L., Crow, S., Blom, T. J., Cuellar-Barboza, A. B., Prieto, M. L., Veldic, M., Winham, S. J., Bobo, W. V., Geske, J., Seymour, L. R., Mori, N., Bond, D. J., Biernacka, J. M., & Frye, M. A. (2016). Clinical features of bipolar spectrum with binge eating behaviour. Journal of Affective Disorders, 201, 95-8. https://doi.org/10.1016/j.jad.2016.05.003
McElroy SL, et al. Clinical Features of Bipolar Spectrum With Binge Eating Behaviour. J Affect Disord. 2016 Sep 1;201:95-8. PubMed PMID: 27195513.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical features of bipolar spectrum with binge eating behaviour. AU - McElroy,Susan L, AU - Crow,Scott, AU - Blom,Thomas J, AU - Cuellar-Barboza,Alfredo B, AU - Prieto,Miguel L, AU - Veldic,Marin, AU - Winham,Stacey J, AU - Bobo,William V, AU - Geske,Jennifer, AU - Seymour,Lisa R, AU - Mori,Nicole, AU - Bond,David J, AU - Biernacka,Joanna M, AU - Frye,Mark A, Y1 - 2016/05/06/ PY - 2016/02/19/received PY - 2016/04/19/revised PY - 2016/05/04/accepted PY - 2016/5/20/entrez PY - 2016/5/20/pubmed PY - 2017/10/3/medline KW - Binge eating KW - Bipolar spectrum SP - 95 EP - 8 JF - Journal of affective disorders JO - J Affect Disord VL - 201 N2 - OBJECTIVE: To determine whether bipolar spectrum disorder with binge eating behavior (BE) is an important clinical sub-phenotype. METHODS: Prevalence rates and correlates of different levels of BE were assessed in 1114 bipolar spectrum patients participating in a genetic biobank. BE and eating disorders (EDs) were assessed with the Eating Disorder Diagnostic Scale (EDDS). Psychiatric illness burden was evaluated with measures of suicidality, psychosis, mood instability, anxiety disorder comorbidity, and substance abuse comorbidity. Medical illness burden was evaluated with body mass index (BMI) and the Cumulative Index Rating Scale (CIRS). RESULTS: Thirty percent of patients had any BE and 27% had BE plus an ED diagnosis. Compared with bipolar spectrum patients without BE, bipolar spectrum patients with BE were younger and more likely to be female; had significantly higher levels of eating psychopathology, suicidality, mood instability, and anxiety disorder comorbidity; had a significantly higher mean BMI and a significantly higher rate of obesity; and had a significantly higher medical illness burden. Bipolar spectrum patients with BE but no ED diagnosis were more similar to bipolar spectrum patients without BE than to those with an ED. Nonetheless, the positive predictive value and specificity of BE predicting an ED was 0.90 and 0.96, respectively. LIMITATIONS: As only two patients had co-occurring anorexia nervosa, these results may not generalize to bipolar spectrum patients with restricting EDs. CONCLUSION: Bipolar spectrum disorder with broadly-defined BE may not be as clinically relevant a sub-phenotype as bipolar spectrum disorder with an ED but may be an adequate proxy for the latter when phenotyping large samples of individuals. SN - 1573-2517 UR - https://www.unboundmedicine.com/medline/citation/27195513/Clinical_features_of_bipolar_spectrum_with_binge_eating_behaviour_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-0327(16)30275-0 DB - PRIME DP - Unbound Medicine ER -