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Clinical evaluation of salivary carbohydrate antigen 125 and leptin in controls and parotid tumours.
Oral Dis. 2016 Oct; 22(7):630-8.OD

Abstract

OBJECTIVES

We determined the correlation between saliva and serum for CA125 and leptin, and evaluated their clinical screening potential for parotid tumours.

SUBJECTS AND METHODS

Serum, acid-stimulated bilateral parotid saliva and chewing-stimulated whole saliva were collected and measured the levels of CA125 and leptin with electrochemiluminescence immunoassay and enzyme-linked immunosorbent assay for healthy controls and patients with unilateral parotid tumour. Intra- and intergroup comparisons were made among them. Correlations and receiver operating curve analyses were also conducted.

RESULTS

There was no correlation between salivary and serum CA125 (r = -0.157-0.265, P > 0.05), while significant correlation was found for leptin (r = 0.219-0.761, P < 0.05). Leptin levels in tumour parotid saliva and CA125 levels in whole saliva were elevated significantly (P < 0.001) and showed screening potential for parotid tumours. Salivary and serum leptin levels were significantly higher in women than in men (P < 0.001).

CONCLUSIONS

Salivary CA125 might originate primarily from salivary gland and tumour rather than from blood, while salivary leptin might originate from both blood and salivary gland. Multiple sources might contribute to the significantly elevated CA125 in whole saliva. Whole saliva CA125 and parotid saliva leptin reflected the occurrence of parotid tumours, while serum CA125 and leptin did not. Salivary CA125 and leptin could not distinguish malignant parotid tumours. When detecting leptin level, the influence of subjects' sex must be considered.

Authors+Show Affiliations

Salivary Gland Disease Center of Beijing Stomatological Hospital, School of Stomatology, Capital Medical University, Beijing, China. Inpatient Department of Oral and Maxillofacial Surgery, Beijing Stomatological Hospital, School of Stomatology, Capital Medical University, Beijing, China.Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, School of Stomatology, Capital Medical University, Beijing, China.School of Biomedical Engineering, Capital Medical University, Beijing, China.Salivary Gland Disease Center of Beijing Stomatological Hospital, School of Stomatology, Capital Medical University, Beijing, China. Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, School of Stomatology, Capital Medical University, Beijing, China.Salivary Gland Disease Center of Beijing Stomatological Hospital, School of Stomatology, Capital Medical University, Beijing, China. lijun3021@aliyun.com. Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, School of Stomatology, Capital Medical University, Beijing, China. lijun3021@aliyun.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27195940

Citation

Zhang, K-Y, et al. "Clinical Evaluation of Salivary Carbohydrate Antigen 125 and Leptin in Controls and Parotid Tumours." Oral Diseases, vol. 22, no. 7, 2016, pp. 630-8.
Zhang KY, Liu CY, Hua L, et al. Clinical evaluation of salivary carbohydrate antigen 125 and leptin in controls and parotid tumours. Oral Dis. 2016;22(7):630-8.
Zhang, K. Y., Liu, C. Y., Hua, L., Wang, S. L., & Li, J. (2016). Clinical evaluation of salivary carbohydrate antigen 125 and leptin in controls and parotid tumours. Oral Diseases, 22(7), 630-8. https://doi.org/10.1111/odi.12505
Zhang KY, et al. Clinical Evaluation of Salivary Carbohydrate Antigen 125 and Leptin in Controls and Parotid Tumours. Oral Dis. 2016;22(7):630-8. PubMed PMID: 27195940.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical evaluation of salivary carbohydrate antigen 125 and leptin in controls and parotid tumours. AU - Zhang,K-Y, AU - Liu,C-Y, AU - Hua,L, AU - Wang,S-L, AU - Li,J, Y1 - 2016/07/04/ PY - 2016/01/31/received PY - 2016/05/07/revised PY - 2016/05/09/accepted PY - 2016/5/20/entrez PY - 2016/5/20/pubmed PY - 2017/9/28/medline KW - carbohydrate antigen 125 KW - leptin KW - parotid tumour KW - saliva KW - serum SP - 630 EP - 8 JF - Oral diseases JO - Oral Dis VL - 22 IS - 7 N2 - OBJECTIVES: We determined the correlation between saliva and serum for CA125 and leptin, and evaluated their clinical screening potential for parotid tumours. SUBJECTS AND METHODS: Serum, acid-stimulated bilateral parotid saliva and chewing-stimulated whole saliva were collected and measured the levels of CA125 and leptin with electrochemiluminescence immunoassay and enzyme-linked immunosorbent assay for healthy controls and patients with unilateral parotid tumour. Intra- and intergroup comparisons were made among them. Correlations and receiver operating curve analyses were also conducted. RESULTS: There was no correlation between salivary and serum CA125 (r = -0.157-0.265, P > 0.05), while significant correlation was found for leptin (r = 0.219-0.761, P < 0.05). Leptin levels in tumour parotid saliva and CA125 levels in whole saliva were elevated significantly (P < 0.001) and showed screening potential for parotid tumours. Salivary and serum leptin levels were significantly higher in women than in men (P < 0.001). CONCLUSIONS: Salivary CA125 might originate primarily from salivary gland and tumour rather than from blood, while salivary leptin might originate from both blood and salivary gland. Multiple sources might contribute to the significantly elevated CA125 in whole saliva. Whole saliva CA125 and parotid saliva leptin reflected the occurrence of parotid tumours, while serum CA125 and leptin did not. Salivary CA125 and leptin could not distinguish malignant parotid tumours. When detecting leptin level, the influence of subjects' sex must be considered. SN - 1601-0825 UR - https://www.unboundmedicine.com/medline/citation/27195940/Clinical_evaluation_of_salivary_carbohydrate_antigen_125 and_leptin_in_controls_and_parotid_tumours_ L2 - https://doi.org/10.1111/odi.12505 DB - PRIME DP - Unbound Medicine ER -