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MAGNETIC RESONANCE IMAGING SCORING OF AN EXPERIMENTAL MODEL OF POST-TRAUMATIC OSTEOARTHRITIS IN THE EQUINE CARPUS.
Vet Radiol Ultrasound. 2016 Sep; 57(5):502-14.VR

Abstract

Magnetic resonance imaging (MRI) is the most sensitive imaging modality to detect the early changes of osteoarthritis. Currently, there is no quantifiable method to tract these pathological changes over time in the horse. The objective of this experimental study was to characterize the progression of MRI changes in an equine model of post-traumatic osteoarthritis using a semiquantitative scoring system for whole-organ evaluation of the middle carpal joint. On day 0, an osteochondral fragment was created in one middle carpal joint (OCI) and the contralateral joint (CON) was sham-operated in 10 horses. On day 14, study horses resumed exercise on a high-speed treadmill until the completion of the study (day 98). High-field MRI examinations were performed on days 0 (preosteochondral fragmentation), 14, and 98 and scored by three blinded observers using consensus agreement. Images were scored based on 15 independent articular features, and scores were compared between and within-groups. On days 14 and 98, OCI joints had significantly (P ≤ 0.05) higher whole-organ median scores (29.0 and 31.5, respectively), compared to CON joints (21.5 and 20.0, respectively). On day 14, OCI joints showed significant increases in high-signal bone lesion scores, and osteochondral fragment number and size. On day 98, high-signal bone lesion, low-signal bone lesion, osteophyte formation, cartilage signal abnormality, subchondral bone irregularity, joint effusion, and synovial thickening scores were significantly increased in OCI joints. Study results suggest that the MRI whole-organ scoring system reported here may be used to identify onset and progression of pathological changes following osteochondral injury.

Authors+Show Affiliations

Department of Large Animal Clinical Sciences, University of Florida College of Veterinary Medicine, University of Florida, Gainesville, FL, 32608.Department of Large Animal Clinical Sciences, University of Florida College of Veterinary Medicine, University of Florida, Gainesville, FL, 32608. mortona@ufl.edu.Department of Small Animal Clinical Sciences, University of Florida College of Veterinary Medicine, University of Florida, Gainesville, FL, 32608.Department of Large Animal Clinical Sciences, University of Florida College of Veterinary Medicine, University of Florida, Gainesville, FL, 32608.Department of Orthopaedics and Rehabilitation, University of Florida College of Medicine, Univeristy of Florida, Gainesville, FL, 32608.Department of Large Animal Clinical Sciences, University of Florida College of Veterinary Medicine, University of Florida, Gainesville, FL, 32608.Department of Large Animal Clinical Sciences, University of Florida College of Veterinary Medicine, University of Florida, Gainesville, FL, 32608.Department of Statistics, University of Central Florida, Orlando, FL, 32816.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27198611

Citation

Smith, Andrew D., et al. "MAGNETIC RESONANCE IMAGING SCORING of an EXPERIMENTAL MODEL of POST-TRAUMATIC OSTEOARTHRITIS in the EQUINE CARPUS." Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association, vol. 57, no. 5, 2016, pp. 502-14.
Smith AD, Morton AJ, Winter MD, et al. MAGNETIC RESONANCE IMAGING SCORING OF AN EXPERIMENTAL MODEL OF POST-TRAUMATIC OSTEOARTHRITIS IN THE EQUINE CARPUS. Vet Radiol Ultrasound. 2016;57(5):502-14.
Smith, A. D., Morton, A. J., Winter, M. D., Colahan, P. T., Ghivizzani, S., Brown, M. P., Hernandez, J. A., & Nickerson, D. M. (2016). MAGNETIC RESONANCE IMAGING SCORING OF AN EXPERIMENTAL MODEL OF POST-TRAUMATIC OSTEOARTHRITIS IN THE EQUINE CARPUS. Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association, 57(5), 502-14. https://doi.org/10.1111/vru.12369
Smith AD, et al. MAGNETIC RESONANCE IMAGING SCORING of an EXPERIMENTAL MODEL of POST-TRAUMATIC OSTEOARTHRITIS in the EQUINE CARPUS. Vet Radiol Ultrasound. 2016;57(5):502-14. PubMed PMID: 27198611.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - MAGNETIC RESONANCE IMAGING SCORING OF AN EXPERIMENTAL MODEL OF POST-TRAUMATIC OSTEOARTHRITIS IN THE EQUINE CARPUS. AU - Smith,Andrew D, AU - Morton,Alison J, AU - Winter,Matthew D, AU - Colahan,Patrick T, AU - Ghivizzani,Steve, AU - Brown,Murray P, AU - Hernandez,Jorge A, AU - Nickerson,David M, Y1 - 2016/05/19/ PY - 2015/04/29/received PY - 2016/02/25/revised PY - 2016/02/29/accepted PY - 2016/5/21/entrez PY - 2016/5/21/pubmed PY - 2017/5/31/medline KW - MRI KW - carpus KW - equine KW - osteoarthritis KW - semiquantitative scoring system SP - 502 EP - 14 JF - Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association JO - Vet Radiol Ultrasound VL - 57 IS - 5 N2 - Magnetic resonance imaging (MRI) is the most sensitive imaging modality to detect the early changes of osteoarthritis. Currently, there is no quantifiable method to tract these pathological changes over time in the horse. The objective of this experimental study was to characterize the progression of MRI changes in an equine model of post-traumatic osteoarthritis using a semiquantitative scoring system for whole-organ evaluation of the middle carpal joint. On day 0, an osteochondral fragment was created in one middle carpal joint (OCI) and the contralateral joint (CON) was sham-operated in 10 horses. On day 14, study horses resumed exercise on a high-speed treadmill until the completion of the study (day 98). High-field MRI examinations were performed on days 0 (preosteochondral fragmentation), 14, and 98 and scored by three blinded observers using consensus agreement. Images were scored based on 15 independent articular features, and scores were compared between and within-groups. On days 14 and 98, OCI joints had significantly (P ≤ 0.05) higher whole-organ median scores (29.0 and 31.5, respectively), compared to CON joints (21.5 and 20.0, respectively). On day 14, OCI joints showed significant increases in high-signal bone lesion scores, and osteochondral fragment number and size. On day 98, high-signal bone lesion, low-signal bone lesion, osteophyte formation, cartilage signal abnormality, subchondral bone irregularity, joint effusion, and synovial thickening scores were significantly increased in OCI joints. Study results suggest that the MRI whole-organ scoring system reported here may be used to identify onset and progression of pathological changes following osteochondral injury. SN - 1740-8261 UR - https://www.unboundmedicine.com/medline/citation/27198611/MAGNETIC_RESONANCE_IMAGING_SCORING_OF_AN_EXPERIMENTAL_MODEL_OF_POST_TRAUMATIC_OSTEOARTHRITIS_IN_THE_EQUINE_CARPUS_ L2 - https://doi.org/10.1111/vru.12369 DB - PRIME DP - Unbound Medicine ER -