Tags

Type your tag names separated by a space and hit enter

Statin-Associated Side Effects.
J Am Coll Cardiol. 2016 05 24; 67(20):2395-2410.JACC

Abstract

Hydroxy-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitors or statins are well tolerated, but associated with various statin-associated symptoms (SAS), including statin-associated muscle symptoms (SAMS), diabetes mellitus (DM), and central nervous system complaints. These are "statin-associated symptoms" because they are rare in clinical trials, making their causative relationship to statins unclear. SAS are, nevertheless, important because they prompt dose reduction or discontinuation of these life-saving mediations. SAMS is the most frequent SAS, and mild myalgia may affect 5% to 10% of statin users. Clinically important muscle symptoms, including rhabdomyolysis and statin-induced necrotizing autoimmune myopathy (SINAM), are rare. Antibodies against HMG-CoA reductase apparently provoke SINAM. Good evidence links statins to DM, but evidence linking statins to other SAS is largely anecdotal. Management of SAS requires making the possible diagnosis, altering or discontinuing the statin treatment, and using alternative lipid-lowering therapy.

Authors+Show Affiliations

Division of Cardiology, Hartford Hospital, Hartford, Connecticut. Electronic address: paul.thompson@hhchealth.org.Division of Cardiology, Hartford Hospital, Hartford, Connecticut; Department of Kinesiology, University of Connecticut, Storrs, Connecticut.Division of Cardiology, Hartford Hospital, Hartford, Connecticut; Department of Kinesiology, University of Connecticut, Storrs, Connecticut.Division of Cardiology, Hartford Hospital, Hartford, Connecticut; Department of Kinesiology, University of Connecticut, Storrs, Connecticut.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

27199064

Citation

Thompson, Paul D., et al. "Statin-Associated Side Effects." Journal of the American College of Cardiology, vol. 67, no. 20, 2016, pp. 2395-2410.
Thompson PD, Panza G, Zaleski A, et al. Statin-Associated Side Effects. J Am Coll Cardiol. 2016;67(20):2395-2410.
Thompson, P. D., Panza, G., Zaleski, A., & Taylor, B. (2016). Statin-Associated Side Effects. Journal of the American College of Cardiology, 67(20), 2395-2410. https://doi.org/10.1016/j.jacc.2016.02.071
Thompson PD, et al. Statin-Associated Side Effects. J Am Coll Cardiol. 2016 05 24;67(20):2395-2410. PubMed PMID: 27199064.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Statin-Associated Side Effects. AU - Thompson,Paul D, AU - Panza,Gregory, AU - Zaleski,Amanda, AU - Taylor,Beth, PY - 2015/09/23/received PY - 2016/02/17/revised PY - 2016/02/17/accepted PY - 2016/5/21/entrez PY - 2016/5/21/pubmed PY - 2017/6/7/medline KW - interstitial lung disease KW - myopathy KW - rhabdomyolysis KW - skeletal muscle SP - 2395 EP - 2410 JF - Journal of the American College of Cardiology JO - J. Am. Coll. Cardiol. VL - 67 IS - 20 N2 - Hydroxy-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitors or statins are well tolerated, but associated with various statin-associated symptoms (SAS), including statin-associated muscle symptoms (SAMS), diabetes mellitus (DM), and central nervous system complaints. These are "statin-associated symptoms" because they are rare in clinical trials, making their causative relationship to statins unclear. SAS are, nevertheless, important because they prompt dose reduction or discontinuation of these life-saving mediations. SAMS is the most frequent SAS, and mild myalgia may affect 5% to 10% of statin users. Clinically important muscle symptoms, including rhabdomyolysis and statin-induced necrotizing autoimmune myopathy (SINAM), are rare. Antibodies against HMG-CoA reductase apparently provoke SINAM. Good evidence links statins to DM, but evidence linking statins to other SAS is largely anecdotal. Management of SAS requires making the possible diagnosis, altering or discontinuing the statin treatment, and using alternative lipid-lowering therapy. SN - 1558-3597 UR - https://www.unboundmedicine.com/medline/citation/27199064/Statin_Associated_Side_Effects_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0735-1097(16)01692-2 DB - PRIME DP - Unbound Medicine ER -