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Hepatitis E: latest developments in knowledge.
Future Microbiol. 2016 06; 11:789-808.FM

Abstract

Hepatitis E, caused by Hepatitis E virus (HEV), is a highly prevalent disease in developing countries. In developed nations, autochthonous HEV infections seem to be an emergent disease. Its clinical manifestations and epidemiology are well known for endemic countries. It has been confirmed that hepatitis E is a zoonosis and that parenteral transmission can also occur. The molecular mechanisms of HEV replication are not fully understood, mostly because there are no efficient cell culture systems. HEV can cause chronic hepatitis in organ transplant recipients and immunocompetent patients. Cases with fulminant hepatitis and other extrahepatic manifestations have also been reported. The diagnosis is based on serological studies and detection of HEV RNA in blood and feces. Treatment with ribavirin and/or pegylated-IFN-α have proven to be successful in some cases. The recently approved/marketed vaccine is a good option in order to prevent this infection.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Pérez-Gracia MT
Área de Microbiología, Departamento de Farmacia, Instituto de Ciencias Biomédicas, Facultad de Ciencias de la Salud, Universidad CEU Cardenal Herrera, Avenida Seminario s/n 46113, Moncada, Valencia, Spain.
Suay-García B
Área de Microbiología, Departamento de Farmacia, Instituto de Ciencias Biomédicas, Facultad de Ciencias de la Salud, Universidad CEU Cardenal Herrera, Avenida Seminario s/n 46113, Moncada, Valencia, Spain.
García M
Área de Microbiología, Departamento de Farmacia, Instituto de Ciencias Biomédicas, Facultad de Ciencias de la Salud, Universidad CEU Cardenal Herrera, Avenida Seminario s/n 46113, Moncada, Valencia, Spain.
Mateos-Lindemann ML
Unidad de Virología, Servicio de Microbiología, Hospital Universitario Ramón y Cajal, Ctra. Colmenar Km 9,1, Madrid 28034, Spain.

MeSH

AnimalsAntiviral AgentsHepatitis EHepatitis E virusHumans

Pub Type(s)

Journal Article
Review
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27203841

Citation

Pérez-Gracia, M Teresa, et al. "Hepatitis E: Latest Developments in Knowledge." Future Microbiology, vol. 11, 2016, pp. 789-808.
Pérez-Gracia MT, Suay-García B, García M, et al. Hepatitis E: latest developments in knowledge. Future Microbiol. 2016;11:789-808.
Pérez-Gracia, M. T., Suay-García, B., García, M., & Mateos-Lindemann, M. L. (2016). Hepatitis E: latest developments in knowledge. Future Microbiology, 11, 789-808. https://doi.org/10.2217/fmb-2016-0012
Pérez-Gracia MT, et al. Hepatitis E: Latest Developments in Knowledge. Future Microbiol. 2016;11:789-808. PubMed PMID: 27203841.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hepatitis E: latest developments in knowledge. AU - Pérez-Gracia,M Teresa, AU - Suay-García,Beatriz, AU - García,Mario, AU - Mateos-Lindemann,M Luisa, Y1 - 2016/05/20/ PY - 2016/5/21/entrez PY - 2016/5/21/pubmed PY - 2017/7/7/medline KW - HEV KW - epidemiology KW - hepatitis E KW - hepatitis E virus KW - replication KW - treatment KW - vaccine SP - 789 EP - 808 JF - Future microbiology JO - Future Microbiol VL - 11 N2 - Hepatitis E, caused by Hepatitis E virus (HEV), is a highly prevalent disease in developing countries. In developed nations, autochthonous HEV infections seem to be an emergent disease. Its clinical manifestations and epidemiology are well known for endemic countries. It has been confirmed that hepatitis E is a zoonosis and that parenteral transmission can also occur. The molecular mechanisms of HEV replication are not fully understood, mostly because there are no efficient cell culture systems. HEV can cause chronic hepatitis in organ transplant recipients and immunocompetent patients. Cases with fulminant hepatitis and other extrahepatic manifestations have also been reported. The diagnosis is based on serological studies and detection of HEV RNA in blood and feces. Treatment with ribavirin and/or pegylated-IFN-α have proven to be successful in some cases. The recently approved/marketed vaccine is a good option in order to prevent this infection. SN - 1746-0921 UR - https://www.unboundmedicine.com/medline/citation/27203841/Hepatitis_E:_latest_developments_in_knowledge_ DB - PRIME DP - Unbound Medicine ER -