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Adipose tissue is prominent in salivary glands of Sjögren's syndrome patients and appears to influence the microenvironment in these organs.
Autoimmunity. 2016 08; 49(5):338-46.A

Abstract

A minor salivary gland (SG) biopsy with focal lymphocytic sialadenitis and a focus score of ≥1 is today's widely accepted pathological finding confirming the SG component of Sjögren's syndrome (SS). Adipocytes can occupy a large percentage of the SG area although little is known about their significance in SS lesions. This study aimed to characterise adipose tissue infiltration in labial SG biopsies from 27 SS patients and 28 non-SS sicca controls. Biopsies were evaluated by one oral pathologist and assessed for focus score, acinar atrophy, fatty replacement and non-specific chronic inflammation. Moreover, to explore the SG microenvironment, immunohistochemical staining of paraffin-embedded SG tissue was performed using interleukin-6 (IL-6). The fatty replacement was evident in all SS patients possessing autoantibodies (Ro/SSA and/or La/SSB) as well as a positive SG biopsy (focus score ≥1). Additionally, 62% of SS patients having autoantibodies but a negative biopsy showed fatty infiltration (FI) while non-SS controls demonstrated fatty replacement in only 32% of the cases. Overall, the SS group (mean age 53.0 years) had a significantly higher incidence (p value 0.005) of FI than the non-SS controls (mean age 54.8 years). Interestingly, adipocytes were located in IL-6 rich areas, and IL-6 positive adipocytes were detected. As fat deposition seems to be more recurrent in SGs affected by SS, we propose the assessment of adipose tissue replacement as a helpful tool for diagnostic evaluation in SS. Detection of IL-6 positive adipocytes suggests their involvement in immune reactions. Still, functional studies are needed to investigate the SG microenvironment further.

Authors+Show Affiliations

a Gade Laboratory for Pathology, Department of Clinical Medicine, University of Bergen , Bergen , Norway . b Department of Pathology , Haukeland University Hospital , Bergen , Norway .a Gade Laboratory for Pathology, Department of Clinical Medicine, University of Bergen , Bergen , Norway . c Department of Oral Surgery and Oral Medicine , University of Oslo , Oslo , Norway .a Gade Laboratory for Pathology, Department of Clinical Medicine, University of Bergen , Bergen , Norway .d Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen , Bergen , Norway , and. e Department of Rheumatology , Haukeland University Hospital , Bergen , Norway.c Department of Oral Surgery and Oral Medicine , University of Oslo , Oslo , Norway .

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27206986

Citation

Skarstein, Kathrine, et al. "Adipose Tissue Is Prominent in Salivary Glands of Sjögren's Syndrome Patients and Appears to Influence the Microenvironment in These Organs." Autoimmunity, vol. 49, no. 5, 2016, pp. 338-46.
Skarstein K, Aqrawi LA, Øijordsbakken G, et al. Adipose tissue is prominent in salivary glands of Sjögren's syndrome patients and appears to influence the microenvironment in these organs. Autoimmunity. 2016;49(5):338-46.
Skarstein, K., Aqrawi, L. A., Øijordsbakken, G., Jonsson, R., & Jensen, J. L. (2016). Adipose tissue is prominent in salivary glands of Sjögren's syndrome patients and appears to influence the microenvironment in these organs. Autoimmunity, 49(5), 338-46. https://doi.org/10.1080/08916934.2016.1183656
Skarstein K, et al. Adipose Tissue Is Prominent in Salivary Glands of Sjögren's Syndrome Patients and Appears to Influence the Microenvironment in These Organs. Autoimmunity. 2016;49(5):338-46. PubMed PMID: 27206986.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adipose tissue is prominent in salivary glands of Sjögren's syndrome patients and appears to influence the microenvironment in these organs. AU - Skarstein,Kathrine, AU - Aqrawi,Lara A, AU - Øijordsbakken,Gunnvor, AU - Jonsson,Roland, AU - Jensen,Janicke Liaaen, Y1 - 2016/05/20/ PY - 2016/5/22/entrez PY - 2016/5/22/pubmed PY - 2017/12/23/medline KW - Fatty replacement KW - Sjögren’s syndrome KW - adipocytes KW - autoimmunity KW - focus score KW - interleukin-6 KW - salivary glands SP - 338 EP - 46 JF - Autoimmunity JO - Autoimmunity VL - 49 IS - 5 N2 - A minor salivary gland (SG) biopsy with focal lymphocytic sialadenitis and a focus score of ≥1 is today's widely accepted pathological finding confirming the SG component of Sjögren's syndrome (SS). Adipocytes can occupy a large percentage of the SG area although little is known about their significance in SS lesions. This study aimed to characterise adipose tissue infiltration in labial SG biopsies from 27 SS patients and 28 non-SS sicca controls. Biopsies were evaluated by one oral pathologist and assessed for focus score, acinar atrophy, fatty replacement and non-specific chronic inflammation. Moreover, to explore the SG microenvironment, immunohistochemical staining of paraffin-embedded SG tissue was performed using interleukin-6 (IL-6). The fatty replacement was evident in all SS patients possessing autoantibodies (Ro/SSA and/or La/SSB) as well as a positive SG biopsy (focus score ≥1). Additionally, 62% of SS patients having autoantibodies but a negative biopsy showed fatty infiltration (FI) while non-SS controls demonstrated fatty replacement in only 32% of the cases. Overall, the SS group (mean age 53.0 years) had a significantly higher incidence (p value 0.005) of FI than the non-SS controls (mean age 54.8 years). Interestingly, adipocytes were located in IL-6 rich areas, and IL-6 positive adipocytes were detected. As fat deposition seems to be more recurrent in SGs affected by SS, we propose the assessment of adipose tissue replacement as a helpful tool for diagnostic evaluation in SS. Detection of IL-6 positive adipocytes suggests their involvement in immune reactions. Still, functional studies are needed to investigate the SG microenvironment further. SN - 1607-842X UR - https://www.unboundmedicine.com/medline/citation/27206986/Adipose_tissue_is_prominent_in_salivary_glands_of_Sjögren's_syndrome_patients_and_appears_to_influence_the_microenvironment_in_these_organs_ L2 - https://www.tandfonline.com/doi/full/10.1080/08916934.2016.1183656 DB - PRIME DP - Unbound Medicine ER -