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Differences in Hemoglobin A1c Between Hispanics/Latinos and Non-Hispanic Whites: An Analysis of the Hispanic Community Health Study/Study of Latinos and the 2007-2012 National Health and Nutrition Examination Survey.
Diabetes Care. 2016 Jun; 39(6):1010-7.DC

Abstract

OBJECTIVE

To determine whether, after adjustment for glycemia and other selected covariates, hemoglobin A1c (HbA1c) differed among adults from six Hispanic/Latino heritage groups (Central American, Cuban, Dominican, Mexican, Puerto Rican, and South American) and between Hispanic/Latino and non-Hispanic white adults without self-reported diabetes.

RESEARCH DESIGN AND METHODS

We performed a cross-sectional analysis of data from 13,083 individuals without self-reported diabetes from six Hispanic/Latino heritage groups, enrolled from 2008 to 2011 in the Hispanic Community Health Study/Study of Latinos, and 2,242 non-Hispanic white adults enrolled during the 2007-2012 cycles of the National Health and Nutrition Examination Survey. We compared HbA1c levels among Hispanics/Latinos and between Hispanics/Latinos and non-Hispanic whites before and after adjustment for age, sex, fasting (FPG) and 2-h post-oral glucose tolerance test (2hPG) glucose, anthropometric measurements, and selected biochemical and hematologic variables and after stratification by diabetes status: unrecognized diabetes (FPG ≥7.1 mmol/L or 2hPG ≥11.2 mmol/L), prediabetes (FPG 5.6-7.0 mmol/L or 2hPG 7.8-11.1 mmol/L), and normal glucose tolerance (FPG <5.6 mmol/L and 2hPG <7.8 mmol/L).

RESULTS

Adjusted mean HbA1c differed significantly across all seven groups (P < 0.001). Non-Hispanic whites had significantly lower HbA1c (P < 0.05) than each individual Hispanic/Latino heritage group. Upon stratification by diabetes status, statistically significant differences (P < 0.001) in adjusted mean HbA1c persisted across all seven groups.

CONCLUSIONS

HbA1c differs among Hispanics/Latinos of diverse heritage groups and between non-Hispanic whites and Hispanics/Latinos after adjustment for glycemia and other covariates. The clinical significance of these differences is unknown.

Authors+Show Affiliations

Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD avilessantal@nhlbi.nih.gov.Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.Columbia University Mailman School of Public Health, New York, NY.Social & Scientific Systems, Inc., Silver Spring, MD.Division of Blood Diseases and Resources, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN.Collaborative Studies Coordinating Center, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC.Collaborative Studies Coordinating Center, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC.Miller School of Medicine, University of Miami, Miami, FL.Northwestern University Feinberg School of Medicine, Chicago, IL.Department of Psychology, San Diego State University, San Diego, CA.Institute for Behavioral and Community Health, Graduate School of Public Health, San Diego State University, San Diego, CA.National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27208330

Citation

Avilés-Santa, M Larissa, et al. "Differences in Hemoglobin A1c Between Hispanics/Latinos and Non-Hispanic Whites: an Analysis of the Hispanic Community Health Study/Study of Latinos and the 2007-2012 National Health and Nutrition Examination Survey." Diabetes Care, vol. 39, no. 6, 2016, pp. 1010-7.
Avilés-Santa ML, Hsu LL, Arredondo M, et al. Differences in Hemoglobin A1c Between Hispanics/Latinos and Non-Hispanic Whites: An Analysis of the Hispanic Community Health Study/Study of Latinos and the 2007-2012 National Health and Nutrition Examination Survey. Diabetes Care. 2016;39(6):1010-7.
Avilés-Santa, M. L., Hsu, L. L., Arredondo, M., Menke, A., Werner, E., Thyagarajan, B., Heiss, G., Teng, Y., Schneiderman, N., Giachello, A. L., Gallo, L. C., Talavera, G. A., & Cowie, C. C. (2016). Differences in Hemoglobin A1c Between Hispanics/Latinos and Non-Hispanic Whites: An Analysis of the Hispanic Community Health Study/Study of Latinos and the 2007-2012 National Health and Nutrition Examination Survey. Diabetes Care, 39(6), 1010-7. https://doi.org/10.2337/dc15-2579
Avilés-Santa ML, et al. Differences in Hemoglobin A1c Between Hispanics/Latinos and Non-Hispanic Whites: an Analysis of the Hispanic Community Health Study/Study of Latinos and the 2007-2012 National Health and Nutrition Examination Survey. Diabetes Care. 2016;39(6):1010-7. PubMed PMID: 27208330.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differences in Hemoglobin A1c Between Hispanics/Latinos and Non-Hispanic Whites: An Analysis of the Hispanic Community Health Study/Study of Latinos and the 2007-2012 National Health and Nutrition Examination Survey. AU - Avilés-Santa,M Larissa, AU - Hsu,Lucy L, AU - Arredondo,Mario, AU - Menke,Andy, AU - Werner,Ellen, AU - Thyagarajan,Bharat, AU - Heiss,Gerardo, AU - Teng,Yanping, AU - Schneiderman,Neil, AU - Giachello,Aida L, AU - Gallo,Linda C, AU - Talavera,Gregory A, AU - Cowie,Catherine C, Y1 - 2016/04/18/ PY - 2015/11/29/received PY - 2016/03/25/accepted PY - 2016/5/22/entrez PY - 2016/5/22/pubmed PY - 2017/10/25/medline SP - 1010 EP - 7 JF - Diabetes care JO - Diabetes Care VL - 39 IS - 6 N2 - OBJECTIVE: To determine whether, after adjustment for glycemia and other selected covariates, hemoglobin A1c (HbA1c) differed among adults from six Hispanic/Latino heritage groups (Central American, Cuban, Dominican, Mexican, Puerto Rican, and South American) and between Hispanic/Latino and non-Hispanic white adults without self-reported diabetes. RESEARCH DESIGN AND METHODS: We performed a cross-sectional analysis of data from 13,083 individuals without self-reported diabetes from six Hispanic/Latino heritage groups, enrolled from 2008 to 2011 in the Hispanic Community Health Study/Study of Latinos, and 2,242 non-Hispanic white adults enrolled during the 2007-2012 cycles of the National Health and Nutrition Examination Survey. We compared HbA1c levels among Hispanics/Latinos and between Hispanics/Latinos and non-Hispanic whites before and after adjustment for age, sex, fasting (FPG) and 2-h post-oral glucose tolerance test (2hPG) glucose, anthropometric measurements, and selected biochemical and hematologic variables and after stratification by diabetes status: unrecognized diabetes (FPG ≥7.1 mmol/L or 2hPG ≥11.2 mmol/L), prediabetes (FPG 5.6-7.0 mmol/L or 2hPG 7.8-11.1 mmol/L), and normal glucose tolerance (FPG <5.6 mmol/L and 2hPG <7.8 mmol/L). RESULTS: Adjusted mean HbA1c differed significantly across all seven groups (P < 0.001). Non-Hispanic whites had significantly lower HbA1c (P < 0.05) than each individual Hispanic/Latino heritage group. Upon stratification by diabetes status, statistically significant differences (P < 0.001) in adjusted mean HbA1c persisted across all seven groups. CONCLUSIONS: HbA1c differs among Hispanics/Latinos of diverse heritage groups and between non-Hispanic whites and Hispanics/Latinos after adjustment for glycemia and other covariates. The clinical significance of these differences is unknown. SN - 1935-5548 UR - https://www.unboundmedicine.com/medline/citation/27208330/Differences_in_Hemoglobin_A1c_Between_Hispanics/Latinos_and_Non_Hispanic_Whites:_An_Analysis_of_the_Hispanic_Community_Health_Study/Study_of_Latinos_and_the_2007_2012_National_Health_and_Nutrition_Examination_Survey_ L2 - http://care.diabetesjournals.org/cgi/pmidlookup?view=long&amp;pmid=27208330 DB - PRIME DP - Unbound Medicine ER -