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Targeting MicroRNAs Involved in the BDNF Signaling Impairment in Neurodegenerative Diseases.
Neuromolecular Med. 2016 Dec; 18(4):540-550.NM

Abstract

Neurodegenerative diseases are becoming an ever-increasing problem in aging populations. Low levels of brain-derived neurotrophic factor (BDNF) have previously been associated with the pathogenesis of numerous neurodegenerative diseases. Recently, microRNAs (miRNAs) have been proposed as potential novel therapeutic targets for treating various diseases of the central nervous system (CNS), and interestingly, few studies have reported several miRNAs that downregulate the expression levels of BDNF. However, substantial challenges exist when attempting to translate these findings into practical anti-miRNA therapeutics, especially when the targets remain inside the CNS. Thus, in this review, we summarize the specific molecular mechanisms by which several miRNAs negatively modulate the expressions of BDNF, address the potential clinical difficulties that can be faced during the development of anti-miRNA-based therapeutics and propose strategies to overcome these challenges.

Authors+Show Affiliations

You HJ
Yonsei University, College of Medicine, Seoul, Korea.
Park JH
Yonsei University, College of Medicine, Seoul, Korea.
Pareja-Galeano H
European University of Madrid, Madrid, Spain. Research Institute of Hospital 12 de Octubre ('i+12'), Madrid, Spain.
Lucia A
European University of Madrid, Madrid, Spain. Research Institute of Hospital 12 de Octubre ('i+12'), Madrid, Spain.
Shin JI
Department of Pediatrics, Yonsei University College of Medicine, Yonsei-Ro 50, Seodaemun-Gu, C.P.O. Box 8044, Seoul, 120-752, Korea. shinji@yuhs.ac.

MeSH

Brain-Derived Neurotrophic FactorGene Expression RegulationGenetic TherapyHumansMicroRNAsNeurodegenerative DiseasesSignal Transduction

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

27209362

Citation

You, Hwa Jeong, et al. "Targeting MicroRNAs Involved in the BDNF Signaling Impairment in Neurodegenerative Diseases." Neuromolecular Medicine, vol. 18, no. 4, 2016, pp. 540-550.
You HJ, Park JH, Pareja-Galeano H, et al. Targeting MicroRNAs Involved in the BDNF Signaling Impairment in Neurodegenerative Diseases. Neuromolecular Med. 2016;18(4):540-550.
You, H. J., Park, J. H., Pareja-Galeano, H., Lucia, A., & Shin, J. I. (2016). Targeting MicroRNAs Involved in the BDNF Signaling Impairment in Neurodegenerative Diseases. Neuromolecular Medicine, 18(4), 540-550.
You HJ, et al. Targeting MicroRNAs Involved in the BDNF Signaling Impairment in Neurodegenerative Diseases. Neuromolecular Med. 2016;18(4):540-550. PubMed PMID: 27209362.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Targeting MicroRNAs Involved in the BDNF Signaling Impairment in Neurodegenerative Diseases. AU - You,Hwa Jeong, AU - Park,Jae Hyon, AU - Pareja-Galeano,Helios, AU - Lucia,Alejandro, AU - Shin,Jae Il, Y1 - 2016/05/21/ PY - 2016/02/11/received PY - 2016/05/12/accepted PY - 2016/5/23/pubmed PY - 2018/5/11/medline PY - 2016/5/23/entrez KW - Brain-derived neurotrophic factor KW - MicroRNA KW - Therapeutic SP - 540 EP - 550 JF - Neuromolecular medicine JO - Neuromolecular Med VL - 18 IS - 4 N2 - Neurodegenerative diseases are becoming an ever-increasing problem in aging populations. Low levels of brain-derived neurotrophic factor (BDNF) have previously been associated with the pathogenesis of numerous neurodegenerative diseases. Recently, microRNAs (miRNAs) have been proposed as potential novel therapeutic targets for treating various diseases of the central nervous system (CNS), and interestingly, few studies have reported several miRNAs that downregulate the expression levels of BDNF. However, substantial challenges exist when attempting to translate these findings into practical anti-miRNA therapeutics, especially when the targets remain inside the CNS. Thus, in this review, we summarize the specific molecular mechanisms by which several miRNAs negatively modulate the expressions of BDNF, address the potential clinical difficulties that can be faced during the development of anti-miRNA-based therapeutics and propose strategies to overcome these challenges. SN - 1559-1174 UR - https://www.unboundmedicine.com/medline/citation/27209362/Targeting_MicroRNAs_Involved_in_the_BDNF_Signaling_Impairment_in_Neurodegenerative_Diseases_ DB - PRIME DP - Unbound Medicine ER -