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Composition of very-low-density lipoproteins in non-insulin-dependent diabetes mellitus.
Clin Chem. 1989 May; 35(5):808-12.CC

Abstract

We studied the characteristics of very-low-density lipoproteins (VLDLs) composition in patients with non-insulin-dependent diabetes mellitus. VLDLs were isolated from 28 diabetics and 33 nondiabetics with a wide range of plasma lipid concentrations, so we could compare VLDL composition between the two groups at similar lipid concentrations. The mean cholesterol and triglyceride concentrations in plasma of diabetic subjects were 2170 (SD 570) and 2510 (SD 2230) mg/L, respectively, and 2230 (SD 560) and 2210 (SD 1830) mg/L in nondiabetics. Diabetic subjects showed positive correlations between plasma triglyceride concentrations and either preprandial blood glucose or glycated hemoglobin values (P less than 0.02 and less than 0.01, respectively). Concentrations of triglycerides, cholesterol, and apolipoproteins (apo) B, CII, CIII, and E in VLDL were not significantly different between diabetics and nondiabetics. At comparable triglyceride concentrations, the chemical compositions of the VLDL in the two groups were still very similar. Dividing the concentration of each component by the VLDL-apo B concentrations yielded similar contents of each component per unit of VLDL for the two groups. We conclude that the composition of VLDLs in diabetics is much the same as that in nondiabetics at comparable concentrations of triglycerides in plasma.

Authors+Show Affiliations

3rd Department of Internal Medicine, University of Tokyo, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2720974

Citation

Ishibashi, S, et al. "Composition of Very-low-density Lipoproteins in Non-insulin-dependent Diabetes Mellitus." Clinical Chemistry, vol. 35, no. 5, 1989, pp. 808-12.
Ishibashi S, Yamada N, Shimano H, et al. Composition of very-low-density lipoproteins in non-insulin-dependent diabetes mellitus. Clin Chem. 1989;35(5):808-12.
Ishibashi, S., Yamada, N., Shimano, H., Takaku, F., Akanuma, Y., & Murase, T. (1989). Composition of very-low-density lipoproteins in non-insulin-dependent diabetes mellitus. Clinical Chemistry, 35(5), 808-12.
Ishibashi S, et al. Composition of Very-low-density Lipoproteins in Non-insulin-dependent Diabetes Mellitus. Clin Chem. 1989;35(5):808-12. PubMed PMID: 2720974.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Composition of very-low-density lipoproteins in non-insulin-dependent diabetes mellitus. AU - Ishibashi,S, AU - Yamada,N, AU - Shimano,H, AU - Takaku,F, AU - Akanuma,Y, AU - Murase,T, PY - 1989/5/1/pubmed PY - 1989/5/1/medline PY - 1989/5/1/entrez SP - 808 EP - 12 JF - Clinical chemistry JO - Clin Chem VL - 35 IS - 5 N2 - We studied the characteristics of very-low-density lipoproteins (VLDLs) composition in patients with non-insulin-dependent diabetes mellitus. VLDLs were isolated from 28 diabetics and 33 nondiabetics with a wide range of plasma lipid concentrations, so we could compare VLDL composition between the two groups at similar lipid concentrations. The mean cholesterol and triglyceride concentrations in plasma of diabetic subjects were 2170 (SD 570) and 2510 (SD 2230) mg/L, respectively, and 2230 (SD 560) and 2210 (SD 1830) mg/L in nondiabetics. Diabetic subjects showed positive correlations between plasma triglyceride concentrations and either preprandial blood glucose or glycated hemoglobin values (P less than 0.02 and less than 0.01, respectively). Concentrations of triglycerides, cholesterol, and apolipoproteins (apo) B, CII, CIII, and E in VLDL were not significantly different between diabetics and nondiabetics. At comparable triglyceride concentrations, the chemical compositions of the VLDL in the two groups were still very similar. Dividing the concentration of each component by the VLDL-apo B concentrations yielded similar contents of each component per unit of VLDL for the two groups. We conclude that the composition of VLDLs in diabetics is much the same as that in nondiabetics at comparable concentrations of triglycerides in plasma. SN - 0009-9147 UR - https://www.unboundmedicine.com/medline/citation/2720974/Composition_of_very_low_density_lipoproteins_in_non_insulin_dependent_diabetes_mellitus_ L2 - https://www.diseaseinfosearch.org/result/2236 DB - PRIME DP - Unbound Medicine ER -