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Does Maternal Vitamin D Deficiency Increase the Risk of Preterm Birth: A Meta-Analysis of Observational Studies.
Nutrients 2016; 8(5)N

Abstract

There are disagreements among researchers about the association between vitamin D deficiency during pregnancy and preterm birth (PTB). Therefore, we conducted a meta-analysis of observational studies to evaluate this association. We performed a systematic literature search of PubMed, MEDLINE and the Cochrane Library through August 2015 with the following keywords: "vitamin D" or "cholecalciferol" or "25-hydroxyvitamin D" or "25(OH)D" in combination with "premature birth" or "preterm birth" or "PTB" or "preterm delivery" or "PTD" or "prematurity". Our meta-analysis of 10 studies included 10,098 participants and found that pregnant women with vitamin D deficiency (maternal serum 25 (OH) D levels < 20 ng/mL) experienced a significantly increased risk of PTB (odds ratio (OR) = 1.29, 95% confidence intervals(CI): 1.16, 1.45) with low heterogeneity (I² = 25%, p = 0.21). Sensitivity analysis showed that exclusion of any single study did not materially alter the overall combined effect. In the subgroup analyses, we found that heterogeneity was obvious in prospective cohort studies (I² = 60%, p = 0.06). In conclusion, pregnant women with vitamin D deficiency during pregnancy have an increasing risk of PTB.

Authors+Show Affiliations

Department of Prevention Medicine and Pathogenic Biology, Medical School, Hunan University of Chinese Medicine, Changsha 410208, China. powerestlulu@163.com. Department of Social Medicine and Health Management, Xiangya School of Public Health, Central South University, Changsha 410078, China. powerestlulu@163.com.Department of Prevention Medicine and Pathogenic Biology, Medical School, Hunan University of Chinese Medicine, Changsha 410208, China. 2289836475@126.com.Department of Prevention Medicine and Pathogenic Biology, Medical School, Hunan University of Chinese Medicine, Changsha 410208, China.Department of Social Medicine and Health Management, Xiangya School of Public Health, Central South University, Changsha 410078, China. huilanxu1963@sina.com.Department of Mental Health, Brain Hospital of Hunan Province, Changsha 410007, China. luo276@126.com.

Pub Type(s)

Journal Article
Meta-Analysis
Review

Language

eng

PubMed ID

27213444

Citation

Qin, Lu-Lu, et al. "Does Maternal Vitamin D Deficiency Increase the Risk of Preterm Birth: a Meta-Analysis of Observational Studies." Nutrients, vol. 8, no. 5, 2016.
Qin LL, Lu FG, Yang SH, et al. Does Maternal Vitamin D Deficiency Increase the Risk of Preterm Birth: A Meta-Analysis of Observational Studies. Nutrients. 2016;8(5).
Qin, L. L., Lu, F. G., Yang, S. H., Xu, H. L., & Luo, B. A. (2016). Does Maternal Vitamin D Deficiency Increase the Risk of Preterm Birth: A Meta-Analysis of Observational Studies. Nutrients, 8(5), doi:10.3390/nu8050301.
Qin LL, et al. Does Maternal Vitamin D Deficiency Increase the Risk of Preterm Birth: a Meta-Analysis of Observational Studies. Nutrients. 2016 May 20;8(5) PubMed PMID: 27213444.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Does Maternal Vitamin D Deficiency Increase the Risk of Preterm Birth: A Meta-Analysis of Observational Studies. AU - Qin,Lu-Lu, AU - Lu,Fang-Guo, AU - Yang,Sheng-Hui, AU - Xu,Hui-Lan, AU - Luo,Bang-An, Y1 - 2016/05/20/ PY - 2016/01/18/received PY - 2016/04/28/revised PY - 2016/05/11/accepted PY - 2016/5/24/entrez PY - 2016/5/24/pubmed PY - 2017/2/28/medline KW - meta KW - pregnant women KW - preterm birth KW - vitamin D deficiency JF - Nutrients JO - Nutrients VL - 8 IS - 5 N2 - There are disagreements among researchers about the association between vitamin D deficiency during pregnancy and preterm birth (PTB). Therefore, we conducted a meta-analysis of observational studies to evaluate this association. We performed a systematic literature search of PubMed, MEDLINE and the Cochrane Library through August 2015 with the following keywords: "vitamin D" or "cholecalciferol" or "25-hydroxyvitamin D" or "25(OH)D" in combination with "premature birth" or "preterm birth" or "PTB" or "preterm delivery" or "PTD" or "prematurity". Our meta-analysis of 10 studies included 10,098 participants and found that pregnant women with vitamin D deficiency (maternal serum 25 (OH) D levels < 20 ng/mL) experienced a significantly increased risk of PTB (odds ratio (OR) = 1.29, 95% confidence intervals(CI): 1.16, 1.45) with low heterogeneity (I² = 25%, p = 0.21). Sensitivity analysis showed that exclusion of any single study did not materially alter the overall combined effect. In the subgroup analyses, we found that heterogeneity was obvious in prospective cohort studies (I² = 60%, p = 0.06). In conclusion, pregnant women with vitamin D deficiency during pregnancy have an increasing risk of PTB. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/27213444/Does_Maternal_Vitamin_D_Deficiency_Increase_the_Risk_of_Preterm_Birth:_A_Meta_Analysis_of_Observational_Studies_ L2 - http://www.mdpi.com/resolver?pii=nu8050301 DB - PRIME DP - Unbound Medicine ER -