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Luteinizing Hormone Secretion during Gonadotropin-Releasing Hormone Stimulation Tests in Obese Girls with Central Precocious Puberty.
J Clin Res Pediatr Endocrinol. 2016 12 01; 8(4):392-398.JC

Abstract

OBJECTIVE

Girls with precocious puberty have high luteinizing hormone (LH) levels and advanced bone age. Obese children enter puberty at earlier ages than do non-obese children. We analyzed the effects of obesity on LH secretion during gonadotropin-releasing hormone (GnRH) tests in girls with precocious puberty.

METHODS

A total of 981 subjects with idiopathic precocious puberty who had undergone a GnRH stimulation testing between 2008 and 2014 were included in the study. Subjects were divided into three groups based on body mass index (BMI). Auxological data and gonadotropin levels after the GnRH stimulation test were compared.

RESULTS

In Tanner stage 2 girls, peak stimulated LH levels on GnRH test were 11.9±7.5, 10.4±6.4, and 9.1±6.1 IU/L among normal-weight, overweight, and obese subjects, respectively (p=0.035 for all comparisons). In Tanner stage 3 girls, peak stimulated LH levels were 14.9±10.9, 12.8±7.9, and 9.6±6.0 IU/L, respectively (p=0.022 for all comparisons). However, in Tanner stage 4 girls, peak stimulated LH levels were not significantly different among normal, overweight, and obese children. On multivariate analysis, BMI standard deviation score was significantly and negatively associated with peak LH (β=-1.178, p=0.001).

CONCLUSION

In girls with central precocious puberty, increased BMI was associated with slightly lower peak stimulated LH levels at early pubertal stages (Tanner stages 2 and 3). This association was not valid in Tanner stage 4 girls.

Authors+Show Affiliations

No affiliation info availableNo affiliation info availableAjou University School of Medicine, Ajou University Hospital, Department of Pediatrics, Suwon, Korea, Phone: 82-31-219-5166 E-mail: pedhwang@ajou.ac.kr.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27215137

Citation

Lee, Hae Sang, et al. "Luteinizing Hormone Secretion During Gonadotropin-Releasing Hormone Stimulation Tests in Obese Girls With Central Precocious Puberty." Journal of Clinical Research in Pediatric Endocrinology, vol. 8, no. 4, 2016, pp. 392-398.
Lee HS, Yoon JS, Hwang JS. Luteinizing Hormone Secretion during Gonadotropin-Releasing Hormone Stimulation Tests in Obese Girls with Central Precocious Puberty. J Clin Res Pediatr Endocrinol. 2016;8(4):392-398.
Lee, H. S., Yoon, J. S., & Hwang, J. S. (2016). Luteinizing Hormone Secretion during Gonadotropin-Releasing Hormone Stimulation Tests in Obese Girls with Central Precocious Puberty. Journal of Clinical Research in Pediatric Endocrinology, 8(4), 392-398. https://doi.org/10.4274/jcrpe.3091
Lee HS, Yoon JS, Hwang JS. Luteinizing Hormone Secretion During Gonadotropin-Releasing Hormone Stimulation Tests in Obese Girls With Central Precocious Puberty. J Clin Res Pediatr Endocrinol. 2016 12 1;8(4):392-398. PubMed PMID: 27215137.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Luteinizing Hormone Secretion during Gonadotropin-Releasing Hormone Stimulation Tests in Obese Girls with Central Precocious Puberty. AU - Lee,Hae Sang, AU - Yoon,Jong Seo, AU - Hwang,Jin Soon, Y1 - 2016/05/23/ PY - 2016/5/25/pubmed PY - 2017/4/19/medline PY - 2016/5/25/entrez SP - 392 EP - 398 JF - Journal of clinical research in pediatric endocrinology JO - J Clin Res Pediatr Endocrinol VL - 8 IS - 4 N2 - OBJECTIVE: Girls with precocious puberty have high luteinizing hormone (LH) levels and advanced bone age. Obese children enter puberty at earlier ages than do non-obese children. We analyzed the effects of obesity on LH secretion during gonadotropin-releasing hormone (GnRH) tests in girls with precocious puberty. METHODS: A total of 981 subjects with idiopathic precocious puberty who had undergone a GnRH stimulation testing between 2008 and 2014 were included in the study. Subjects were divided into three groups based on body mass index (BMI). Auxological data and gonadotropin levels after the GnRH stimulation test were compared. RESULTS: In Tanner stage 2 girls, peak stimulated LH levels on GnRH test were 11.9±7.5, 10.4±6.4, and 9.1±6.1 IU/L among normal-weight, overweight, and obese subjects, respectively (p=0.035 for all comparisons). In Tanner stage 3 girls, peak stimulated LH levels were 14.9±10.9, 12.8±7.9, and 9.6±6.0 IU/L, respectively (p=0.022 for all comparisons). However, in Tanner stage 4 girls, peak stimulated LH levels were not significantly different among normal, overweight, and obese children. On multivariate analysis, BMI standard deviation score was significantly and negatively associated with peak LH (β=-1.178, p=0.001). CONCLUSION: In girls with central precocious puberty, increased BMI was associated with slightly lower peak stimulated LH levels at early pubertal stages (Tanner stages 2 and 3). This association was not valid in Tanner stage 4 girls. SN - 1308-5735 UR - https://www.unboundmedicine.com/medline/citation/27215137/Luteinizing_Hormone_Secretion_during_Gonadotropin_Releasing_Hormone_Stimulation_Tests_in_Obese_Girls_with_Central_Precocious_Puberty_ L2 - https://doi.org/10.4274/jcrpe.3091 DB - PRIME DP - Unbound Medicine ER -