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Outer retinal deformity detected by optical coherence tomography in eyes with foveal hypoplasia.
Graefes Arch Clin Exp Ophthalmol. 2016 Nov; 254(11):2197-2201.GA

Abstract

PURPOSE

To investigate the relationship between vision and foveal maturity, especially in foveal hypoplasia exhibiting severe structural immaturity.

METHODS

This retrospective observational case series included 42 eyes of 23 patients (mean age, 7.0 ± 5.0 years; 9 patients with foveal hypoplasia as an isolated entity and 14 patients with aniridia). A complete ophthalmic examination included measurement of best-corrected visual acuity (BCVA) and spectral-domain optical coherence tomography (SD-OCT). The sensory retina, ganglion cell complex (GCC), and outer retinal layers, including Henle's fiber layer (HFL), were measured and analyzed.

RESULTS

Using SD-OCT images, eyes were classified as having a differentiated (6 eyes), diffuse (19 eyes), or no HFL (17 eyes), based on the appearance of the HFL around the foveal region. The logMAR BCVA was significantly worse (p < 0.0001) in eyes with diffuse HFL and those with no HFL than in those with differentiated HFL. Outer retinal thickness (outer plexiform layer + HFL + outer nuclear layer) was less (p = 0.0051) in eyes with no HFL than in those with differentiated HFL. The logMAR BCVA, GCC thickness, and outer retinal thickness in eyes with foveal hypoplasia with aniridia were significantly worse (p = 0.0083), thicker (p = 0.0039), and thinner (p = 0.0001), respectively, than in eyes with foveal hypoplasia as an isolated entity.

CONCLUSIONS

In eyes with foveal hypoplasia with severe structural immaturity, diffuse HFL or no HFL was associated with worse vision. There was greater foveal immaturity in eyes with foveal hypoplasia with aniridia compared with foveal hypoplasia as an isolated entity.

Authors+Show Affiliations

Department of Ophthalmology and Laboratory for Visual Science, National Center for Child Health and Development, 2-10-1, Okura, Setagaya-ku, Tokyo, 157-8535, Japan. Department of Ophthalmology, The Jikei University School of Medicine, Tokyo, Japan.Department of Ophthalmology and Laboratory for Visual Science, National Center for Child Health and Development, 2-10-1, Okura, Setagaya-ku, Tokyo, 157-8535, Japan.Division of Biostatistics, Center for Clinical Research and Development, National Center for Child Health and Development, Tokyo, Japan.Department of Ophthalmology and Laboratory for Visual Science, National Center for Child Health and Development, 2-10-1, Okura, Setagaya-ku, Tokyo, 157-8535, Japan.Department of Ophthalmology and Laboratory for Visual Science, National Center for Child Health and Development, 2-10-1, Okura, Setagaya-ku, Tokyo, 157-8535, Japan. azuma-n@ncchd.go.jp.

Pub Type(s)

Journal Article
Observational Study

Language

eng

PubMed ID

27216762

Citation

Katagiri, Satoshi, et al. "Outer Retinal Deformity Detected By Optical Coherence Tomography in Eyes With Foveal Hypoplasia." Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie, vol. 254, no. 11, 2016, pp. 2197-2201.
Katagiri S, Yokoi T, Mikami M, et al. Outer retinal deformity detected by optical coherence tomography in eyes with foveal hypoplasia. Graefes Arch Clin Exp Ophthalmol. 2016;254(11):2197-2201.
Katagiri, S., Yokoi, T., Mikami, M., Nishina, S., & Azuma, N. (2016). Outer retinal deformity detected by optical coherence tomography in eyes with foveal hypoplasia. Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie, 254(11), 2197-2201.
Katagiri S, et al. Outer Retinal Deformity Detected By Optical Coherence Tomography in Eyes With Foveal Hypoplasia. Graefes Arch Clin Exp Ophthalmol. 2016;254(11):2197-2201. PubMed PMID: 27216762.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Outer retinal deformity detected by optical coherence tomography in eyes with foveal hypoplasia. AU - Katagiri,Satoshi, AU - Yokoi,Tadashi, AU - Mikami,Masashi, AU - Nishina,Sachiko, AU - Azuma,Noriyuki, Y1 - 2016/05/23/ PY - 2016/01/19/received PY - 2016/05/10/accepted PY - 2016/05/07/revised PY - 2016/10/27/pubmed PY - 2019/3/21/medline PY - 2016/5/25/entrez KW - Aniridia KW - Foveal hypoplasia KW - Henle’s fiber layer KW - Isolated KW - Optical coherence tomography SP - 2197 EP - 2201 JF - Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie JO - Graefes Arch Clin Exp Ophthalmol VL - 254 IS - 11 N2 - PURPOSE: To investigate the relationship between vision and foveal maturity, especially in foveal hypoplasia exhibiting severe structural immaturity. METHODS: This retrospective observational case series included 42 eyes of 23 patients (mean age, 7.0 ± 5.0 years; 9 patients with foveal hypoplasia as an isolated entity and 14 patients with aniridia). A complete ophthalmic examination included measurement of best-corrected visual acuity (BCVA) and spectral-domain optical coherence tomography (SD-OCT). The sensory retina, ganglion cell complex (GCC), and outer retinal layers, including Henle's fiber layer (HFL), were measured and analyzed. RESULTS: Using SD-OCT images, eyes were classified as having a differentiated (6 eyes), diffuse (19 eyes), or no HFL (17 eyes), based on the appearance of the HFL around the foveal region. The logMAR BCVA was significantly worse (p < 0.0001) in eyes with diffuse HFL and those with no HFL than in those with differentiated HFL. Outer retinal thickness (outer plexiform layer + HFL + outer nuclear layer) was less (p = 0.0051) in eyes with no HFL than in those with differentiated HFL. The logMAR BCVA, GCC thickness, and outer retinal thickness in eyes with foveal hypoplasia with aniridia were significantly worse (p = 0.0083), thicker (p = 0.0039), and thinner (p = 0.0001), respectively, than in eyes with foveal hypoplasia as an isolated entity. CONCLUSIONS: In eyes with foveal hypoplasia with severe structural immaturity, diffuse HFL or no HFL was associated with worse vision. There was greater foveal immaturity in eyes with foveal hypoplasia with aniridia compared with foveal hypoplasia as an isolated entity. SN - 1435-702X UR - https://www.unboundmedicine.com/medline/citation/27216762/Outer_retinal_deformity_detected_by_optical_coherence_tomography_in_eyes_with_foveal_hypoplasia_ L2 - https://dx.doi.org/10.1007/s00417-016-3385-z DB - PRIME DP - Unbound Medicine ER -