Tags

Type your tag names separated by a space and hit enter

Longitudinal improvement and stability of olfactory function in the evaluation of surgical management for chronic rhinosinusitis.
Int Forum Allergy Rhinol. 2016 11; 6(11):1188-1195.IF

Abstract

BACKGROUND

Abnormal olfaction is common with chronic rhinosinusitis (CRS) and associates with various measures of sinonasal inflammation. The Brief Smell Identification Test (BSIT) has demonstrated improvements in abnormal olfactory detection following endoscopic sinus surgery (ESS), but olfaction remains understudied using this instrument. Discerning longitudinal, postoperative durability in olfaction is critical for patient counseling.

METHODS

Adult participants with medically recalcitrant CRS were prospectively enrolled into a multi-institutional cohort study and observed for 18 months after ESS. Olfaction was operationalized using BSIT scores collected at baseline, 6 months, 12 months, and 18 months postoperatively and compared using repeated measures analysis of variance (ANOVA).

RESULTS

A total of 122 participants met inclusion criteria and were recruited between March 2011 and February 2014. Improvement in mean BSIT scores at 6-month follow-up were reported for all participants (p = 0.014) with greatest improvement in subjects with nasal polyposis (p = 0.001). No differences in mean BSIT scores were found between 6 months and 18 months overall; however, subjects with comorbid asthma (F(2) = 5.29; p = 0.010) and nasal polyposis (F(2) = 3.99; p = 0.033) reported significant mean worsening. Prevalence of abnormal olfaction decreased from 28% preoperatively to 17% at 6 months (p = 0.015), for all subjects, without significant change at 12 months (19%; p = 0.791) or at 18 months (21%; p = 0.581) postoperatively.

CONCLUSION

Postoperative improvement in olfaction was reported 6 months after ESS using BSIT scores, with greatest improvements in patients undergoing polypectomy. Overall improvement persisted between 6 months and 18 months after ESS for most patient subgroups; however, dysosmia worsened after initial improvement in patients with asthma and nasal polyps, highlighting the need for further identification of prognostic factors associated with abnormal olfaction in CRS.

Authors+Show Affiliations

Department of Otolaryngology-Head and Neck Surgery, Division of Rhinology and Skull Base Surgery, Oregon Health and Science University, Portland, OR.Department of Otolaryngology-Head and Neck Surgery, Division of Rhinology and Skull Base Surgery, Oregon Health and Science University, Portland, OR.Department of Otolaryngology-Head and Neck Surgery, Division of Rhinology and Skull Base Surgery, Oregon Health and Science University, Portland, OR.Department of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, SC.Department of Otolaryngology-Head and Neck Surgery, Division of Rhinology and Skull Base Surgery, Oregon Health and Science University, Portland, OR. smithtim@ohsu.edu.

Pub Type(s)

Journal Article
Multicenter Study
Observational Study
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

27218483

Citation

Levy, Joshua M., et al. "Longitudinal Improvement and Stability of Olfactory Function in the Evaluation of Surgical Management for Chronic Rhinosinusitis." International Forum of Allergy & Rhinology, vol. 6, no. 11, 2016, pp. 1188-1195.
Levy JM, Mace JC, Sansoni ER, et al. Longitudinal improvement and stability of olfactory function in the evaluation of surgical management for chronic rhinosinusitis. Int Forum Allergy Rhinol. 2016;6(11):1188-1195.
Levy, J. M., Mace, J. C., Sansoni, E. R., Soler, Z. M., & Smith, T. L. (2016). Longitudinal improvement and stability of olfactory function in the evaluation of surgical management for chronic rhinosinusitis. International Forum of Allergy & Rhinology, 6(11), 1188-1195. https://doi.org/10.1002/alr.21800
Levy JM, et al. Longitudinal Improvement and Stability of Olfactory Function in the Evaluation of Surgical Management for Chronic Rhinosinusitis. Int Forum Allergy Rhinol. 2016;6(11):1188-1195. PubMed PMID: 27218483.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Longitudinal improvement and stability of olfactory function in the evaluation of surgical management for chronic rhinosinusitis. AU - Levy,Joshua M, AU - Mace,Jess C, AU - Sansoni,E Ritter, AU - Soler,Zachary M, AU - Smith,Timothy L, Y1 - 2016/05/24/ PY - 2016/02/25/received PY - 2016/04/04/revised PY - 2016/04/09/accepted PY - 2016/11/4/pubmed PY - 2017/11/14/medline PY - 2016/5/25/entrez KW - chronic disease KW - endoscopy KW - longitudinal studies KW - sinusitis KW - smell SP - 1188 EP - 1195 JF - International forum of allergy & rhinology JO - Int Forum Allergy Rhinol VL - 6 IS - 11 N2 - BACKGROUND: Abnormal olfaction is common with chronic rhinosinusitis (CRS) and associates with various measures of sinonasal inflammation. The Brief Smell Identification Test (BSIT) has demonstrated improvements in abnormal olfactory detection following endoscopic sinus surgery (ESS), but olfaction remains understudied using this instrument. Discerning longitudinal, postoperative durability in olfaction is critical for patient counseling. METHODS: Adult participants with medically recalcitrant CRS were prospectively enrolled into a multi-institutional cohort study and observed for 18 months after ESS. Olfaction was operationalized using BSIT scores collected at baseline, 6 months, 12 months, and 18 months postoperatively and compared using repeated measures analysis of variance (ANOVA). RESULTS: A total of 122 participants met inclusion criteria and were recruited between March 2011 and February 2014. Improvement in mean BSIT scores at 6-month follow-up were reported for all participants (p = 0.014) with greatest improvement in subjects with nasal polyposis (p = 0.001). No differences in mean BSIT scores were found between 6 months and 18 months overall; however, subjects with comorbid asthma (F(2) = 5.29; p = 0.010) and nasal polyposis (F(2) = 3.99; p = 0.033) reported significant mean worsening. Prevalence of abnormal olfaction decreased from 28% preoperatively to 17% at 6 months (p = 0.015), for all subjects, without significant change at 12 months (19%; p = 0.791) or at 18 months (21%; p = 0.581) postoperatively. CONCLUSION: Postoperative improvement in olfaction was reported 6 months after ESS using BSIT scores, with greatest improvements in patients undergoing polypectomy. Overall improvement persisted between 6 months and 18 months after ESS for most patient subgroups; however, dysosmia worsened after initial improvement in patients with asthma and nasal polyps, highlighting the need for further identification of prognostic factors associated with abnormal olfaction in CRS. SN - 2042-6984 UR - https://www.unboundmedicine.com/medline/citation/27218483/Longitudinal_improvement_and_stability_of_olfactory_function_in_the_evaluation_of_surgical_management_for_chronic_rhinosinusitis_ L2 - https://doi.org/10.1002/alr.21800 DB - PRIME DP - Unbound Medicine ER -