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Evaluation of foveal photoreceptor layer in eyes with macular edema associated with branch retinal vein occlusion after ozurdex treatment.
Int Ophthalmol. 2017 Apr; 37(2):333-339.IO

Abstract

The aim of this study was to evaluate the central retinal thickness (CRT), outer nuclear layer thickness (ONLT), photoreceptor layer thickness (PLT), photoreceptor layer integrity, and the correlation between visual acuity and PLT in eyes with branch retinal vein occlusion (BRVO) 2 months after treatment with intravitreal dexamethasone implant (Ozurdex; Allergan, Inc, Irvine, CA). In this prospective study, 32 eyes of 32 patients were enrolled. A single injection of Ozurdex was administered to all the patients. CRT, ONLT, and PLT were measured using spectral-domain optical coherence tomography before and 2 months after the injection. Best-corrected visual acuity (BCVA [logMAR]) and photoreceptor cell integrity were also evaluated. The average CRT, ONLT, PLT, and BCVA values for the sample group before the treatment were as follows: 707 ± 261, 608 ± 288, 70 ± 25, and 0.96 ± 0.22 µm, respectively. The average CRT, ONLT, PLT, and BCVA values for the sample group 2 months after the Ozurdex injection were as follows: 299 ± 149, 211 ± 138, 77 ± 20, and 0.63 ± 0.30 µm, respectively (p < 0.05). Two months after the Ozurdex injection, BCVA correlated with ONLT and PLT (r = 0.365, p = 0.048 and r = -0.488, p = 0.021, respectively), whereas BCVA was not correlated with CRT (r = 0.239, p = 0.189). Photoreceptor layer is associated with the visual function of eyes with macular edema secondary to BRVO. Also, ONLT seems to be more closely related to visual acuity improvement than CRT decrement.

Authors+Show Affiliations

Department of Ophthalmology, Kayseri Education and Research Hospital, Kayseri, Turkey. orhan_altunel@hotmail.com.Department of Ophthalmology, Kayseri Education and Research Hospital, Kayseri, Turkey.Department of Ophthalmology, Acibadem Kayseri Hospital, Kayseri, Turkey.Department of Ophthalmology, Kayseri Education and Research Hospital, Kayseri, Turkey.Department of Ophthalmology, Kayseri Education and Research Hospital, Kayseri, Turkey.Department of Ophthalmology, Kayseri Education and Research Hospital, Kayseri, Turkey.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27221365

Citation

Altunel, Orhan, et al. "Evaluation of Foveal Photoreceptor Layer in Eyes With Macular Edema Associated With Branch Retinal Vein Occlusion After Ozurdex Treatment." International Ophthalmology, vol. 37, no. 2, 2017, pp. 333-339.
Altunel O, Duru N, Goktas A, et al. Evaluation of foveal photoreceptor layer in eyes with macular edema associated with branch retinal vein occlusion after ozurdex treatment. Int Ophthalmol. 2017;37(2):333-339.
Altunel, O., Duru, N., Goktas, A., Ozkose, A., Goktas, E., & Atas, M. (2017). Evaluation of foveal photoreceptor layer in eyes with macular edema associated with branch retinal vein occlusion after ozurdex treatment. International Ophthalmology, 37(2), 333-339. https://doi.org/10.1007/s10792-016-0261-0
Altunel O, et al. Evaluation of Foveal Photoreceptor Layer in Eyes With Macular Edema Associated With Branch Retinal Vein Occlusion After Ozurdex Treatment. Int Ophthalmol. 2017;37(2):333-339. PubMed PMID: 27221365.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of foveal photoreceptor layer in eyes with macular edema associated with branch retinal vein occlusion after ozurdex treatment. AU - Altunel,Orhan, AU - Duru,Necati, AU - Goktas,Altan, AU - Ozkose,Ayse, AU - Goktas,Emre, AU - Atas,Mustafa, Y1 - 2016/05/25/ PY - 2016/02/09/received PY - 2016/05/13/accepted PY - 2016/5/26/pubmed PY - 2017/8/10/medline PY - 2016/5/26/entrez KW - Branch retinal vein occlusion KW - Ozurdex KW - Photoreceptor layer integrity KW - Photoreceptor layer thickness SP - 333 EP - 339 JF - International ophthalmology JO - Int Ophthalmol VL - 37 IS - 2 N2 - The aim of this study was to evaluate the central retinal thickness (CRT), outer nuclear layer thickness (ONLT), photoreceptor layer thickness (PLT), photoreceptor layer integrity, and the correlation between visual acuity and PLT in eyes with branch retinal vein occlusion (BRVO) 2 months after treatment with intravitreal dexamethasone implant (Ozurdex; Allergan, Inc, Irvine, CA). In this prospective study, 32 eyes of 32 patients were enrolled. A single injection of Ozurdex was administered to all the patients. CRT, ONLT, and PLT were measured using spectral-domain optical coherence tomography before and 2 months after the injection. Best-corrected visual acuity (BCVA [logMAR]) and photoreceptor cell integrity were also evaluated. The average CRT, ONLT, PLT, and BCVA values for the sample group before the treatment were as follows: 707 ± 261, 608 ± 288, 70 ± 25, and 0.96 ± 0.22 µm, respectively. The average CRT, ONLT, PLT, and BCVA values for the sample group 2 months after the Ozurdex injection were as follows: 299 ± 149, 211 ± 138, 77 ± 20, and 0.63 ± 0.30 µm, respectively (p < 0.05). Two months after the Ozurdex injection, BCVA correlated with ONLT and PLT (r = 0.365, p = 0.048 and r = -0.488, p = 0.021, respectively), whereas BCVA was not correlated with CRT (r = 0.239, p = 0.189). Photoreceptor layer is associated with the visual function of eyes with macular edema secondary to BRVO. Also, ONLT seems to be more closely related to visual acuity improvement than CRT decrement. SN - 1573-2630 UR - https://www.unboundmedicine.com/medline/citation/27221365/Evaluation_of_foveal_photoreceptor_layer_in_eyes_with_macular_edema_associated_with_branch_retinal_vein_occlusion_after_ozurdex_treatment_ L2 - https://doi.org/10.1007/s10792-016-0261-0 DB - PRIME DP - Unbound Medicine ER -