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Lack of transmission among healthcare workers in contact with a case of Middle East respiratory syndrome coronavirus infection in Thailand.

Abstract

INTRODUCTION

A hospital-associated outbreak of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) was reported. We aimed to assess the effectiveness of infection control measures among healthcare workers (HCWs) who were exposed to a MERS patient and/or his body fluids in our institute.

METHODS

A descriptive study was conducted among HCWs who worked with a MERS patient in Bamrasnaradura Infectious Diseases Institute, Thailand, between 18 June and 3 July 2015. Contacts were defined as HCWs who worked in the patient's room or with the patient's body fluids. Serum samples from all contacts were collected within 14 days of last contact and one month later. Paired sera were tested for detection of MERS-CoV antibodies by using an indirect ELISA.

RESULTS

Thirty-eight (88.4 %) of 43 identified contacts consented to enroll. The mean (SD) age was 38.1 (11.1) years, and 79 % were females. The median (IQR) cumulative duration of work of HCWs in the patient's room was 35 (20-165) minutes. The median (IQR) cumulative duration of work of HCWs with the patient's blood or body fluids in laboratory was 67.5 (43.7-117.5) minutes. All contacts reported 100 % compliance with hand hygiene, using N95 respirator, performing respirator fit test, wearing gown, gloves, eye protection, and cap during their entire working period. All serum specimens of contacts tested for MERS-CoV antibodies were negative.

CONCLUSIONS

We provide evidence of effective infection control practices against MERS-CoV transmission in a healthcare facility. Strict infection control precautions can protect HCWs. The optimal infection control measures for MERS-CoV should be further evaluated.

Authors+Show Affiliations

Bamrasnaradura Infectious Diseases Institute, Ministry of Public Health, Nonthaburi, 11000 Thailand.Bamrasnaradura Infectious Diseases Institute, Ministry of Public Health, Nonthaburi, 11000 Thailand.Bamrasnaradura Infectious Diseases Institute, Ministry of Public Health, Nonthaburi, 11000 Thailand.Bamrasnaradura Infectious Diseases Institute, Ministry of Public Health, Nonthaburi, 11000 Thailand.Bamrasnaradura Infectious Diseases Institute, Ministry of Public Health, Nonthaburi, 11000 Thailand.Bamrasnaradura Infectious Diseases Institute, Ministry of Public Health, Nonthaburi, 11000 Thailand.Bamrasnaradura Infectious Diseases Institute, Ministry of Public Health, Nonthaburi, 11000 Thailand.Faculty of Medical Technology, Mahidol University, Bangkok, Thailand.Faculty of Medical Technology, Mahidol University, Bangkok, Thailand ; Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27222710

Citation

Wiboonchutikul, Surasak, et al. "Lack of Transmission Among Healthcare Workers in Contact With a Case of Middle East Respiratory Syndrome Coronavirus Infection in Thailand." Antimicrobial Resistance and Infection Control, vol. 5, 2016, p. 21.
Wiboonchutikul S, Manosuthi W, Likanonsakul S, et al. Lack of transmission among healthcare workers in contact with a case of Middle East respiratory syndrome coronavirus infection in Thailand. Antimicrob Resist Infect Control. 2016;5:21.
Wiboonchutikul, S., Manosuthi, W., Likanonsakul, S., Sangsajja, C., Kongsanan, P., Nitiyanontakij, R., Thientong, V., Lerdsamran, H., & Puthavathana, P. (2016). Lack of transmission among healthcare workers in contact with a case of Middle East respiratory syndrome coronavirus infection in Thailand. Antimicrobial Resistance and Infection Control, 5, 21. https://doi.org/10.1186/s13756-016-0120-9
Wiboonchutikul S, et al. Lack of Transmission Among Healthcare Workers in Contact With a Case of Middle East Respiratory Syndrome Coronavirus Infection in Thailand. Antimicrob Resist Infect Control. 2016;5:21. PubMed PMID: 27222710.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lack of transmission among healthcare workers in contact with a case of Middle East respiratory syndrome coronavirus infection in Thailand. AU - Wiboonchutikul,Surasak, AU - Manosuthi,Weerawat, AU - Likanonsakul,Sirirat, AU - Sangsajja,Chariya, AU - Kongsanan,Paweena, AU - Nitiyanontakij,Ravee, AU - Thientong,Varaporn, AU - Lerdsamran,Hatairat, AU - Puthavathana,Pilaipan, Y1 - 2016/05/23/ PY - 2016/03/25/received PY - 2016/05/16/accepted PY - 2016/5/26/entrez PY - 2016/5/26/pubmed PY - 2016/5/26/medline KW - Healthcare facilities KW - Healthcare workers KW - MERS-CoV KW - Middle East respiratory syndrome KW - Transmission SP - 21 EP - 21 JF - Antimicrobial resistance and infection control JO - Antimicrob Resist Infect Control VL - 5 N2 - INTRODUCTION: A hospital-associated outbreak of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) was reported. We aimed to assess the effectiveness of infection control measures among healthcare workers (HCWs) who were exposed to a MERS patient and/or his body fluids in our institute. METHODS: A descriptive study was conducted among HCWs who worked with a MERS patient in Bamrasnaradura Infectious Diseases Institute, Thailand, between 18 June and 3 July 2015. Contacts were defined as HCWs who worked in the patient's room or with the patient's body fluids. Serum samples from all contacts were collected within 14 days of last contact and one month later. Paired sera were tested for detection of MERS-CoV antibodies by using an indirect ELISA. RESULTS: Thirty-eight (88.4 %) of 43 identified contacts consented to enroll. The mean (SD) age was 38.1 (11.1) years, and 79 % were females. The median (IQR) cumulative duration of work of HCWs in the patient's room was 35 (20-165) minutes. The median (IQR) cumulative duration of work of HCWs with the patient's blood or body fluids in laboratory was 67.5 (43.7-117.5) minutes. All contacts reported 100 % compliance with hand hygiene, using N95 respirator, performing respirator fit test, wearing gown, gloves, eye protection, and cap during their entire working period. All serum specimens of contacts tested for MERS-CoV antibodies were negative. CONCLUSIONS: We provide evidence of effective infection control practices against MERS-CoV transmission in a healthcare facility. Strict infection control precautions can protect HCWs. The optimal infection control measures for MERS-CoV should be further evaluated. SN - 2047-2994 UR - https://www.unboundmedicine.com/medline/citation/27222710/full_citation L2 - https://aricjournal.biomedcentral.com/articles/10.1186/s13756-016-0120-9 DB - PRIME DP - Unbound Medicine ER -