Tags

Type your tag names separated by a space and hit enter

Sugar Sag: Glycation and the Role of Diet in Aging Skin.
Skin Therapy Lett. 2015 Nov; 20(6):1-5.ST

Abstract

First described in the context of diabetes, advanced glycation end products (AGEs) are formed through a type of non-enzymatic reaction called glycation. Increased accumulation of AGEs in human tissue has now been associated with end stage renal disease, chronic obstructive pulmonary disease, and, recently, skin aging. Characteristic findings of aging skin, including decreased resistance to mechanical stress, impaired wound healing, and distorted dermal vasculature, can be in part attributable to glycation. Multiple factors mediate cutaneous senescence, and these factors are generally characterized as endogenous (e.g., telomere shortening) or exogenous (e.g., ultraviolet radiation exposure). Interestingly, AGEs exert their pathophysiological effects from both endogenous and exogenous routes. The former entails the consumption of sugar in the diet, which then covalently binds an electron from a donor molecule to form an AGE. The latter process mostly refers to the formation of AGEs through cooking. Recent studies have revealed that certain methods of food preparation (i.e., grilling, frying, and roasting) produce much higher levels of AGEs than water-based cooking methods such as boiling and steaming. Moreover, several dietary compounds have emerged as promising candidates for the inhibition of glycation-mediated aging. In this review, we summarize the evidence supporting the critical role of glycation in skin aging and highlight preliminary studies on dietary strategies that may be able to combat this process.

Authors+Show Affiliations

Department of Dermatology, Baylor College of Medicine, Houston, TX, USA.Department of Dermatology, Baylor College of Medicine, Houston, TX, USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

27224842

Citation

Nguyen, H P., and R Katta. "Sugar Sag: Glycation and the Role of Diet in Aging Skin." Skin Therapy Letter, vol. 20, no. 6, 2015, pp. 1-5.
Nguyen HP, Katta R. Sugar Sag: Glycation and the Role of Diet in Aging Skin. Skin Therapy Lett. 2015;20(6):1-5.
Nguyen, H. P., & Katta, R. (2015). Sugar Sag: Glycation and the Role of Diet in Aging Skin. Skin Therapy Letter, 20(6), 1-5.
Nguyen HP, Katta R. Sugar Sag: Glycation and the Role of Diet in Aging Skin. Skin Therapy Lett. 2015;20(6):1-5. PubMed PMID: 27224842.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sugar Sag: Glycation and the Role of Diet in Aging Skin. AU - Nguyen,H P, AU - Katta,R, PY - 2016/5/26/entrez PY - 2016/5/26/pubmed PY - 2017/4/1/medline SP - 1 EP - 5 JF - Skin therapy letter JO - Skin Therapy Lett. VL - 20 IS - 6 N2 - First described in the context of diabetes, advanced glycation end products (AGEs) are formed through a type of non-enzymatic reaction called glycation. Increased accumulation of AGEs in human tissue has now been associated with end stage renal disease, chronic obstructive pulmonary disease, and, recently, skin aging. Characteristic findings of aging skin, including decreased resistance to mechanical stress, impaired wound healing, and distorted dermal vasculature, can be in part attributable to glycation. Multiple factors mediate cutaneous senescence, and these factors are generally characterized as endogenous (e.g., telomere shortening) or exogenous (e.g., ultraviolet radiation exposure). Interestingly, AGEs exert their pathophysiological effects from both endogenous and exogenous routes. The former entails the consumption of sugar in the diet, which then covalently binds an electron from a donor molecule to form an AGE. The latter process mostly refers to the formation of AGEs through cooking. Recent studies have revealed that certain methods of food preparation (i.e., grilling, frying, and roasting) produce much higher levels of AGEs than water-based cooking methods such as boiling and steaming. Moreover, several dietary compounds have emerged as promising candidates for the inhibition of glycation-mediated aging. In this review, we summarize the evidence supporting the critical role of glycation in skin aging and highlight preliminary studies on dietary strategies that may be able to combat this process. SN - 1201-5989 UR - https://www.unboundmedicine.com/medline/citation/27224842/Sugar_Sag:_Glycation_and_the_Role_of_Diet_in_Aging_Skin_ L2 - http://www.skintherapyletter.com/2015/20.6/1.html DB - PRIME DP - Unbound Medicine ER -