A palladium-catalyzed intramolecular carbonylative annulation reaction for the synthesis of 4,5-fused tricyclic 2-quinolones.Chem Commun (Camb). 2016 Jun 08; 52(49):7665-7.CC
Abstract
A concise and efficient synthetic route to 4,5-fused tricyclic 2-quinolones through the palladium-catalyzed carbonylative annulation of alkyne-tethered N-substituted o-iodoanilines has been developed. This reaction proceeds smoothly under mild reaction conditions and exhibits exceptional tolerance to a variety of functional groups. It has been successfully applied to the efficient synthesis of BI 224436, an HIV integrase inhibitor.
Links
Pub Type(s)
Journal Article
Language
eng
PubMed ID
27225232
Citation
Zhang, Xiwu, et al. "A Palladium-catalyzed Intramolecular Carbonylative Annulation Reaction for the Synthesis of 4,5-fused Tricyclic 2-quinolones." Chemical Communications (Cambridge, England), vol. 52, no. 49, 2016, pp. 7665-7.
Zhang X, Liu H, Jia Y. A palladium-catalyzed intramolecular carbonylative annulation reaction for the synthesis of 4,5-fused tricyclic 2-quinolones. Chem Commun (Camb). 2016;52(49):7665-7.
Zhang, X., Liu, H., & Jia, Y. (2016). A palladium-catalyzed intramolecular carbonylative annulation reaction for the synthesis of 4,5-fused tricyclic 2-quinolones. Chemical Communications (Cambridge, England), 52(49), 7665-7. https://doi.org/10.1039/c6cc02600a
Zhang X, Liu H, Jia Y. A Palladium-catalyzed Intramolecular Carbonylative Annulation Reaction for the Synthesis of 4,5-fused Tricyclic 2-quinolones. Chem Commun (Camb). 2016 Jun 8;52(49):7665-7. PubMed PMID: 27225232.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - A palladium-catalyzed intramolecular carbonylative annulation reaction for the synthesis of 4,5-fused tricyclic 2-quinolones.
AU - Zhang,Xiwu,
AU - Liu,Haichao,
AU - Jia,Yanxing,
PY - 2016/5/27/entrez
PY - 2016/5/27/pubmed
PY - 2016/5/27/medline
SP - 7665
EP - 7
JF - Chemical communications (Cambridge, England)
JO - Chem Commun (Camb)
VL - 52
IS - 49
N2 - A concise and efficient synthetic route to 4,5-fused tricyclic 2-quinolones through the palladium-catalyzed carbonylative annulation of alkyne-tethered N-substituted o-iodoanilines has been developed. This reaction proceeds smoothly under mild reaction conditions and exhibits exceptional tolerance to a variety of functional groups. It has been successfully applied to the efficient synthesis of BI 224436, an HIV integrase inhibitor.
SN - 1364-548X
UR - https://www.unboundmedicine.com/medline/citation/27225232/A_palladium_catalyzed_intramolecular_carbonylative_annulation_reaction_for_the_synthesis_of_45_fused_tricyclic_2_quinolones_
DB - PRIME
DP - Unbound Medicine
ER -
