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Cardiometabolic risk markers of normal weight and excess body weight in Brazilian adolescents.
Appl Physiol Nutr Metab. 2016 Jun; 41(6):659-65.AP

Abstract

Excess body weight leads to a variety of metabolic changes and increases the risk for cardiovascular diseases (CVD) in adulthood. The objective of this study was to investigate the presence of risk markers for CVD among Brazilian adolescents of normal weight and with excess body weight. The markers included blood pressure, C-reactive protein, homocysteine, tumor necrosis factor alpha, fibrinogen, fasting insulin and glucose, homeostasis model assessment of insulin resistance (HOMA-IR), leptin, total cholesterol, low-density lipoprotein cholesterol (LDL-c), high-density lipoprotein cholesterol (HDL-c), and triglycerides. We calculated odds ratios (OR) using logistic regression and adjusted for potential confounders such as age, sex, physical activity, and socioeconomic background. Compared with normal weight subjects, overweight/obese adolescents were more likely to have higher systolic blood pressure (OR = 3.49, p < 0.001), fasting insulin (OR = 8.03, p < 0.001), HOMA-IR (OR = 8.03, p < 0.001), leptin (OR = 5.55, p < 0.001), and LDL-c (OR = 5.50, p < 0.001) and lower serum HDL-c concentrations (OR = 2.76, p = 0.004). After adjustment for confounders, the estimates did not change substantially, except for leptin for which the risk associated with overweight increased to 11.09 (95% CI: 4.05-30.35). In conclusion, excess body weight in adolescents exhibits strong associations with several markers that are established as causes of CVD in adults. This observation stresses the importance of primary prevention and of maintaining a healthy body weight throughout adolescence to reduce the global burden of CVD.

Authors+Show Affiliations

a Department of Physical Education, University of Joinville Region, Rua Paulo Malschitzki, no. 10, Joinville, 89219-710, Brazil. b Population Health Intervention Research Unit, School of Public Health, University of Alberta, 3-50 University Terrace, 8303 - 112 St., Edmonton, AB T6G 2T4, Canada.b Population Health Intervention Research Unit, School of Public Health, University of Alberta, 3-50 University Terrace, 8303 - 112 St., Edmonton, AB T6G 2T4, Canada. c Post-graduation Program in Health and Environment, University of Joinville Region, Rua Paulo Malschitzki, no. 10, Joinville, 89219-710, Brazil.d Department of Biological Sciences, University of Joinville Region, Rua Paulo Malschitzki, no. 10, Joinville, 89219-710, Brazil.d Department of Biological Sciences, University of Joinville Region, Rua Paulo Malschitzki, no. 10, Joinville, 89219-710, Brazil.e Department of Epidemiology, School of Public Health, University of São Paulo, Av. Dr. Arnaldo, no. 715, São Paulo, 01246-904, Brazil.e Department of Epidemiology, School of Public Health, University of São Paulo, Av. Dr. Arnaldo, no. 715, São Paulo, 01246-904, Brazil.f Department of Pharmacy, University of Joinville Region, Rua Paulo Malschitzki, no. 10, Joinville, 89219-710, Brazil.b Population Health Intervention Research Unit, School of Public Health, University of Alberta, 3-50 University Terrace, 8303 - 112 St., Edmonton, AB T6G 2T4, Canada.g Department of Nutrition, School of Public Health, University of São Paulo, Av. Dr. Arnaldo, no. 715, São Paulo, 01246-904, Brazil.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27227571

Citation

Mastroeni, Silmara Salete de Barros Silva, et al. "Cardiometabolic Risk Markers of Normal Weight and Excess Body Weight in Brazilian Adolescents." Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquee, Nutrition Et Metabolisme, vol. 41, no. 6, 2016, pp. 659-65.
Mastroeni SS, Mastroeni MF, Gonçalves Mde C, et al. Cardiometabolic risk markers of normal weight and excess body weight in Brazilian adolescents. Appl Physiol Nutr Metab. 2016;41(6):659-65.
Mastroeni, S. S., Mastroeni, M. F., Gonçalves, M. d. e. . C., Debortoli, G., da Silva, N. N., Bernal, R. T., Adamovski, M., Veugelers, P. J., & Rondó, P. H. (2016). Cardiometabolic risk markers of normal weight and excess body weight in Brazilian adolescents. Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquee, Nutrition Et Metabolisme, 41(6), 659-65. https://doi.org/10.1139/apnm-2015-0632
Mastroeni SS, et al. Cardiometabolic Risk Markers of Normal Weight and Excess Body Weight in Brazilian Adolescents. Appl Physiol Nutr Metab. 2016;41(6):659-65. PubMed PMID: 27227571.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cardiometabolic risk markers of normal weight and excess body weight in Brazilian adolescents. AU - Mastroeni,Silmara Salete de Barros Silva, AU - Mastroeni,Marco Fabio, AU - Gonçalves,Muryel de Carvalho, AU - Debortoli,Guilherme, AU - da Silva,Nilza Nunes, AU - Bernal,Regina Tomie Ivata, AU - Adamovski,Maristela, AU - Veugelers,Paul J, AU - Rondó,Patrícia Helen de Carvalho, Y1 - 2016/02/18/ PY - 2016/5/27/entrez PY - 2016/5/27/pubmed PY - 2017/2/12/medline KW - adolescents KW - blood pressure KW - cardiometabolic markers KW - cardiovascular disease KW - cholesterol KW - cholestérol KW - insulin KW - insuline KW - leptin KW - leptine KW - maladie cardiovasculaire KW - marqueurs cardiométaboliques KW - obese KW - obèse KW - overweight KW - pression sanguine KW - surpoids SP - 659 EP - 65 JF - Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme JO - Appl Physiol Nutr Metab VL - 41 IS - 6 N2 - Excess body weight leads to a variety of metabolic changes and increases the risk for cardiovascular diseases (CVD) in adulthood. The objective of this study was to investigate the presence of risk markers for CVD among Brazilian adolescents of normal weight and with excess body weight. The markers included blood pressure, C-reactive protein, homocysteine, tumor necrosis factor alpha, fibrinogen, fasting insulin and glucose, homeostasis model assessment of insulin resistance (HOMA-IR), leptin, total cholesterol, low-density lipoprotein cholesterol (LDL-c), high-density lipoprotein cholesterol (HDL-c), and triglycerides. We calculated odds ratios (OR) using logistic regression and adjusted for potential confounders such as age, sex, physical activity, and socioeconomic background. Compared with normal weight subjects, overweight/obese adolescents were more likely to have higher systolic blood pressure (OR = 3.49, p < 0.001), fasting insulin (OR = 8.03, p < 0.001), HOMA-IR (OR = 8.03, p < 0.001), leptin (OR = 5.55, p < 0.001), and LDL-c (OR = 5.50, p < 0.001) and lower serum HDL-c concentrations (OR = 2.76, p = 0.004). After adjustment for confounders, the estimates did not change substantially, except for leptin for which the risk associated with overweight increased to 11.09 (95% CI: 4.05-30.35). In conclusion, excess body weight in adolescents exhibits strong associations with several markers that are established as causes of CVD in adults. This observation stresses the importance of primary prevention and of maintaining a healthy body weight throughout adolescence to reduce the global burden of CVD. SN - 1715-5320 UR - https://www.unboundmedicine.com/medline/citation/27227571/Cardiometabolic_risk_markers_of_normal_weight_and_excess_body_weight_in_Brazilian_adolescents_ L2 - http://www.nrcresearchpress.com/doi/full/10.1139/apnm-2015-0632?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -