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Characterization of Three Venom Peptides from the Spitting Spider Scytodes thoracica.
PLoS One. 2016; 11(5):e0156291.Plos

Abstract

We present the solution-state NMR structures and preliminary functional characterizations of three venom peptides identified from the spitting spider Scytodes thoracica. Despite little sequence identity to other venom peptides, structural characterization reveals that these peptides contain an inhibitor cystine knot motif common to many venom peptides. These are the first structures for any peptide or protein from spiders of the Scytodidae family. Many venom peptides target neuronal ion channels or receptors. However, we have not been able to determine the target of these Scytodes peptides so we can only state with certainty the channels and receptors that they do not target.

Authors+Show Affiliations

Chemistry Department, Lewis & Clark College, 0615 SW Palatine Hill Road, Portland, OR, 97219, United States of America.Chemistry Department, Lewis & Clark College, 0615 SW Palatine Hill Road, Portland, OR, 97219, United States of America.Chemistry Department, Lewis & Clark College, 0615 SW Palatine Hill Road, Portland, OR, 97219, United States of America.Chemistry Department, Lewis & Clark College, 0615 SW Palatine Hill Road, Portland, OR, 97219, United States of America.Chemistry Department, Lewis & Clark College, 0615 SW Palatine Hill Road, Portland, OR, 97219, United States of America.Chemistry Department, Lewis & Clark College, 0615 SW Palatine Hill Road, Portland, OR, 97219, United States of America.Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia.Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia.Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia.Chemistry Department, Lewis & Clark College, 0615 SW Palatine Hill Road, Portland, OR, 97219, United States of America.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27227898

Citation

Ariki, Nathanial K., et al. "Characterization of Three Venom Peptides From the Spitting Spider Scytodes Thoracica." PloS One, vol. 11, no. 5, 2016, pp. e0156291.
Ariki NK, Muñoz LE, Armitage EL, et al. Characterization of Three Venom Peptides from the Spitting Spider Scytodes thoracica. PLoS ONE. 2016;11(5):e0156291.
Ariki, N. K., Muñoz, L. E., Armitage, E. L., Goodstein, F. R., George, K. G., Smith, V. L., Vetter, I., Herzig, V., King, G. F., & Loening, N. M. (2016). Characterization of Three Venom Peptides from the Spitting Spider Scytodes thoracica. PloS One, 11(5), e0156291. https://doi.org/10.1371/journal.pone.0156291
Ariki NK, et al. Characterization of Three Venom Peptides From the Spitting Spider Scytodes Thoracica. PLoS ONE. 2016;11(5):e0156291. PubMed PMID: 27227898.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characterization of Three Venom Peptides from the Spitting Spider Scytodes thoracica. AU - Ariki,Nathanial K, AU - Muñoz,Lisa E, AU - Armitage,Elizabeth L, AU - Goodstein,Francesca R, AU - George,Kathryn G, AU - Smith,Vanessa L, AU - Vetter,Irina, AU - Herzig,Volker, AU - King,Glenn F, AU - Loening,Nikolaus M, Y1 - 2016/05/26/ PY - 2016/03/18/received PY - 2016/05/11/accepted PY - 2016/5/27/entrez PY - 2016/5/27/pubmed PY - 2017/7/28/medline SP - e0156291 EP - e0156291 JF - PloS one JO - PLoS ONE VL - 11 IS - 5 N2 - We present the solution-state NMR structures and preliminary functional characterizations of three venom peptides identified from the spitting spider Scytodes thoracica. Despite little sequence identity to other venom peptides, structural characterization reveals that these peptides contain an inhibitor cystine knot motif common to many venom peptides. These are the first structures for any peptide or protein from spiders of the Scytodidae family. Many venom peptides target neuronal ion channels or receptors. However, we have not been able to determine the target of these Scytodes peptides so we can only state with certainty the channels and receptors that they do not target. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/27227898/Characterization_of_Three_Venom_Peptides_from_the_Spitting_Spider_Scytodes_thoracica_ L2 - http://dx.plos.org/10.1371/journal.pone.0156291 DB - PRIME DP - Unbound Medicine ER -