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Sex Differences in the Risk of Developing Acute Coronary Syndrome in Patients With Sleep Disorders: A Population-Based Cohort Study.
Am J Mens Health. 2017 Sep; 11(5):1560-1568.AJ

Abstract

Studies that focus on the relationship between sex and the risk of acute coronary syndrome (ACS) are scant. The current study investigated the effects of sex differences in the risk of developing ACS in patients with sleep disorders (SDs). This longitudinal population-based cohort study evaluated the incidence and risk of ACS development in 40,232 men and 65,519 women newly diagnosed with SDs between 2002 and 2008 from the Longitudinal Health Insurance Database. The follow-up period began from the entry date and ended on the date of an ACS event or December 31, 2010. Univariable and multivariable Cox proportional hazard regression models were conducted to estimate the sex differences in the risk of ACS. Men with SDs exhibited an increased incidence of ACS compared with women with SDs in all age- and comorbidity-specific subgroups. After covariates were adjusted, the men with SDs exhibited a 1.48-fold adjusted hazard ratio (aHR) of ACS compared with the women with SDs (95% confidence interval [CI] = 1.36-1.60). After age group stratification, the men with SDs in the young adult group exhibited the highest risk of subsequent ACS development compared with the women with SDs (aHR = 2.07, 95% CI = 1.69-2.55), followed by those in middle-aged adults (aHR = 1.52, 95% CI = 1.32-1.76) and older adults groups (aHR = 1.24, 95% CI = 1.11-1.39). This study determined that men with SDs, particularly young men, are at a higher risk of subsequent ACS development compared with women with SDs.

Authors+Show Affiliations

1 Taichung Hospital, Ministry of Health and Welfare, Taichung, Taiwan. 2 China Medical University, Taichung, Taiwan. 3 Central Taiwan University of Science and Technology, Taichung, Taiwan.3 Central Taiwan University of Science and Technology, Taichung, Taiwan.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

27230089

Citation

Chung, Wei-Sheng, and Hsuan-Hung Lin. "Sex Differences in the Risk of Developing Acute Coronary Syndrome in Patients With Sleep Disorders: a Population-Based Cohort Study." American Journal of Men's Health, vol. 11, no. 5, 2017, pp. 1560-1568.
Chung WS, Lin HH. Sex Differences in the Risk of Developing Acute Coronary Syndrome in Patients With Sleep Disorders: A Population-Based Cohort Study. Am J Mens Health. 2017;11(5):1560-1568.
Chung, W. S., & Lin, H. H. (2017). Sex Differences in the Risk of Developing Acute Coronary Syndrome in Patients With Sleep Disorders: A Population-Based Cohort Study. American Journal of Men's Health, 11(5), 1560-1568. https://doi.org/10.1177/1557988316651260
Chung WS, Lin HH. Sex Differences in the Risk of Developing Acute Coronary Syndrome in Patients With Sleep Disorders: a Population-Based Cohort Study. Am J Mens Health. 2017;11(5):1560-1568. PubMed PMID: 27230089.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sex Differences in the Risk of Developing Acute Coronary Syndrome in Patients With Sleep Disorders: A Population-Based Cohort Study. AU - Chung,Wei-Sheng, AU - Lin,Hsuan-Hung, Y1 - 2016/05/26/ PY - 2016/5/28/pubmed PY - 2018/5/17/medline PY - 2016/5/28/entrez KW - acute coronary syndrome KW - population-based cohort study KW - sleep disorders SP - 1560 EP - 1568 JF - American journal of men's health JO - Am J Mens Health VL - 11 IS - 5 N2 - Studies that focus on the relationship between sex and the risk of acute coronary syndrome (ACS) are scant. The current study investigated the effects of sex differences in the risk of developing ACS in patients with sleep disorders (SDs). This longitudinal population-based cohort study evaluated the incidence and risk of ACS development in 40,232 men and 65,519 women newly diagnosed with SDs between 2002 and 2008 from the Longitudinal Health Insurance Database. The follow-up period began from the entry date and ended on the date of an ACS event or December 31, 2010. Univariable and multivariable Cox proportional hazard regression models were conducted to estimate the sex differences in the risk of ACS. Men with SDs exhibited an increased incidence of ACS compared with women with SDs in all age- and comorbidity-specific subgroups. After covariates were adjusted, the men with SDs exhibited a 1.48-fold adjusted hazard ratio (aHR) of ACS compared with the women with SDs (95% confidence interval [CI] = 1.36-1.60). After age group stratification, the men with SDs in the young adult group exhibited the highest risk of subsequent ACS development compared with the women with SDs (aHR = 2.07, 95% CI = 1.69-2.55), followed by those in middle-aged adults (aHR = 1.52, 95% CI = 1.32-1.76) and older adults groups (aHR = 1.24, 95% CI = 1.11-1.39). This study determined that men with SDs, particularly young men, are at a higher risk of subsequent ACS development compared with women with SDs. SN - 1557-9891 UR - https://www.unboundmedicine.com/medline/citation/27230089/Sex_Differences_in_the_Risk_of_Developing_Acute_Coronary_Syndrome_in_Patients_With_Sleep_Disorders:_A_Population_Based_Cohort_Study_ L2 - https://journals.sagepub.com/doi/10.1177/1557988316651260?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -